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mark4b MAP/microtubule affinity-regulating kinase 4b [ Danio rerio (zebrafish) ]

Gene ID: 571279, updated on 25-Apr-2024

Summary

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Official Symbol
mark4bprovided by ZNC
Official Full Name
MAP/microtubule affinity-regulating kinase 4bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-100330-2
See related
Ensembl:ENSDARG00000024966 AllianceGenome:ZFIN:ZDB-GENE-100330-2
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mark4; si:dkey-31m14.7
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (23551051..23641516)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (23615790..23706251)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:dkey-182i3.10 Neighboring gene si:dkey-182i3.11 Neighboring gene creatine kinase, muscle b Neighboring gene kinesin light chain 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Repertoire of protein kinases encoded in the genome of zebrafish shows remarkably large population of PIM kinases. Rakshambikai R, et al. J Bioinform Comput Biol, 2014 Feb. PMID 24467753
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MAP/microtubule affinity-regulating kinase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    23551051..23641516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157598.4 → XP_005157655.1  MAP/microtubule affinity-regulating kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B3S3
    Conserved Domains (4) summary
    cd12197
    Location:699 → 796
    MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
    smart00220
    Location:58 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:57 → 309
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:327 → 369
    UBA_like_SF; UBA domain-like superfamily

  2. XM_009291741.3 → XP_009290016.1  MAP/microtubule affinity-regulating kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AHI1
    Conserved Domains (4) summary
    cd12197
    Location:695 → 792
    MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
    smart00220
    Location:58 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:57 → 309
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:327 → 369
    UBA_like_SF; UBA domain-like superfamily

  3. XM_009291742.3 → XP_009290017.1  MAP/microtubule affinity-regulating kinase 4 isoform X6

    UniProtKB/TrEMBL
    A0A8M3B160
    Conserved Domains (3) summary
    smart00220
    Location:58 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:57 → 309
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:327 → 369
    UBA_like_SF; UBA domain-like superfamily

  4. XM_017351181.2 → XP_017206670.1  MAP/microtubule affinity-regulating kinase 4 isoform X7

    UniProtKB/TrEMBL
    A0A8M6Z0W8

  5. XM_009291745.3 → XP_009290020.1  MAP/microtubule affinity-regulating kinase 4 isoform X9

    UniProtKB/TrEMBL
    A0A8M3AIL5
    Conserved Domains (3) summary
    smart00220
    Location:58 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:57 → 309
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:327 → 369
    UBA_like_SF; UBA domain-like superfamily

  6. XM_021466418.1 → XP_021322093.1  MAP/microtubule affinity-regulating kinase 4 isoform X8

    UniProtKB/TrEMBL
    A0A8M9PCD9
    Conserved Domains (2) summary
    cd14072
    Location:57 → 309
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:327 → 369
    UBA_like_SF; UBA domain-like superfamily

  7. XM_021466419.1 → XP_021322094.1  MAP/microtubule affinity-regulating kinase 4 isoform X8

    UniProtKB/TrEMBL
    A0A8M9PCD9
    Conserved Domains (2) summary
    cd14072
    Location:57 → 309
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:327 → 369
    UBA_like_SF; UBA domain-like superfamily

  8. XM_694854.9 → XP_699946.4  MAP/microtubule affinity-regulating kinase 4 isoform X5

    UniProtKB/TrEMBL
    A0A8N7T8N0, R4GEN1
    Related
    ENSDARP00000126944.1, ENSDART00000152720.3
    Conserved Domains (3) summary
    smart00220
    Location:58 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:57 → 309
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:327 → 369
    UBA_like_SF; UBA domain-like superfamily

  9. XM_017351180.2 → XP_017206669.1  MAP/microtubule affinity-regulating kinase 4 isoform X3

    UniProtKB/TrEMBL
    A0A8M6YSI3

  10. XM_005157600.4 → XP_005157657.1  MAP/microtubule affinity-regulating kinase 4 isoform X4

    UniProtKB/TrEMBL
    A0A8M2B3S4
    Conserved Domains (4) summary
    cd12197
    Location:658 → 755
    MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
    smart00220
    Location:58 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:57 → 309
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:327 → 369
    UBA_like_SF; UBA domain-like superfamily

  11. XM_005157603.4 → XP_005157660.1  MAP/microtubule affinity-regulating kinase 4 isoform X10

    UniProtKB/TrEMBL
    A0A8M2B3X7
    Conserved Domains (3) summary
    smart00220
    Location:58 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14072
    Location:57 → 309
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
    cl21463
    Location:327 → 369
    UBA_like_SF; UBA domain-like superfamily
Nucleotide Protein
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