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MARK4 microtubule affinity regulating kinase 4 [ Homo sapiens (human) ]

Gene ID: 57787, updated on 8-Oct-2018

Summary

Official Symbol
MARK4provided by HGNC
Official Full Name
microtubule affinity regulating kinase 4provided by HGNC
Primary source
HGNC:HGNC:13538
See related
Ensembl:ENSG00000007047 MIM:606495; Vega:OTTHUMG00000181769
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MARK4L; MARK4S; MARKL1; PAR-1D; MARKL1L
Summary
This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Expression
Broad expression in testis (RPKM 14.0), brain (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See MARK4 in Genome Data Viewer
Location:
19q13.32
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (45251258..45305283)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45754516..45808541)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 6A Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 3 Neighboring gene exocyst complex component 3 like 2 Neighboring gene exocyst complex component 3 like 4 pseudogene Neighboring gene heart enhancer 22 Neighboring gene creatine kinase, M-type

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Anchoring of the basal body to the plasma membrane, organism-specific biosystem (from REACTOME)
    Anchoring of the basal body to the plasma membrane, organism-specific biosystemCilium biogenesis is initiated by the docking of basal bodies, a centriole-derived organelle, to the plasma membrane (reviewed in Reiter et al, 2012). The centriole consists of a multiprotein core su...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    LKB1 signaling events, organism-specific biosystem
    LKB1 signaling events
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12177, FLJ90097, KIAA1860

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
gamma-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tau-protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
tau-protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
cilium organization IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule bundle formation IEP
Inferred from Expression Pattern
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of programmed cell death NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
gamma-tubulin complex IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
microtubule organizing center IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
MAP/microtubule affinity-regulating kinase 4
Names
MAP/microtubule affinity-regulating kinase like 1
MARK4 serine/threonine protein kinase
epididymis secretory sperm binding protein
NP_001186796.1
NP_113605.2
XP_006723370.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199867.1NP_001186796.1  MAP/microtubule affinity-regulating kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_001186796.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AB049127, AB058763, AY120867, DB100014
    Consensus CDS
    CCDS56097.1
    UniProtKB/Swiss-Prot
    Q96L34
    Related
    ENSP00000262891.3, OTTHUMP00000267428, ENST00000262891.8, OTTHUMT00000457537
    Conserved Domains (4) summary
    cd12197
    Location:654752
    MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
    smart00220
    Location:59310
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:328370
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:58310
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
  2. NM_031417.3NP_113605.2  MAP/microtubule affinity-regulating kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_113605.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB049127, AB058763, DB100014
    Consensus CDS
    CCDS12658.1
    UniProtKB/Swiss-Prot
    Q96L34
    Related
    ENSP00000300843.3, OTTHUMP00000267429, ENST00000300843.8, OTTHUMT00000457538
    Conserved Domains (3) summary
    smart00220
    Location:59310
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:328370
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cd14072
    Location:58310
    STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    45251258..45305283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723307.4XP_006723370.1  MAP/microtubule affinity-regulating kinase 4 isoform X1

    Conserved Domains (4) summary
    cd12197
    Location:587685
    MARK4_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinase 4
    smart00220
    Location:12243
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14407
    Location:261303
    UBA_MARK3_4; UBA domain found in MAP/microtubule affinity-regulating kinase MARK3, MARK4, and similar proteins
    cl21453
    Location:18243
    PKc_like; Protein Kinases, catalytic domain
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