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fat2 FAT atypical cadherin 2 [ Danio rerio (zebrafish) ]

Gene ID: 568468, updated on 11-Apr-2024

Summary

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Official Symbol
fat2provided by ZNC
Official Full Name
FAT atypical cadherin 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-111031-1
See related
Ensembl:ENSDARG00000018923 AllianceGenome:ZFIN:ZDB-GENE-111031-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fk09f07; wu:fk09f07
Summary
Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in adherens junction. Is expressed in cerebellum; granule cell; hindbrain; and optic tectum. Human ortholog(s) of this gene implicated in spinocerebellar ataxia 45. Orthologous to human FAT2 (FAT atypical cadherin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 14
Exon count:
24
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (26103330..26177148, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (25806088..25879899, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 member 1 Neighboring gene antioxidant 1 copper chaperone Neighboring gene melatonin receptor type 1A like Neighboring gene ganglioside GM2 activator-like Neighboring gene ganglioside GM2 activator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dynamic gene expression by putative hair-cell progenitors during regeneration in the zebrafish lateral line. Steiner AB, et al. Proc Natl Acad Sci U S A, 2014 Apr 8. PMID 24706895, Free PMC Article
  2. New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Maugars G, et al. Front Endocrinol (Lausanne), 2020. PMID 33071966, Free PMC Article
  3. Rab32 and Rab38 genes in chordate pigmentation: an evolutionary perspective. Coppola U, et al. BMC Evol Biol, 2016 Jan 27. PMID 26818140, Free PMC Article
  4. Gene expression profiling of granule cells and Purkinje cells in the zebrafish cerebellum. Takeuchi M, et al. J Comp Neurol, 2017 May 1. PMID 27615194
  5. Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. Liu Y, et al. Elife, 2022 May 19. PMID 35588359, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protocadherin Fat 2
Names
FAT tumor suppressor homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    26103330..26177148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001920023.7 → XP_001920058.2  protocadherin Fat 2

    UniProtKB/TrEMBL
    A0A8M1QQM9, E7FB42
    Related
    ENSDARP00000014029.8, ENSDART00000014149.11
    Conserved Domains (3) summary
    cd11304
    Location:3319 → 3416
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:3941 → 3978
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:3766 → 3912
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
Nucleotide Protein Strain
Heading Accession and Version

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