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osbpl1a oxysterol binding protein-like 1A [ Danio rerio (zebrafish) ]

Gene ID: 565503, updated on 11-Apr-2024

Summary

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Official Symbol
osbpl1aprovided by ZNC
Official Full Name
oxysterol binding protein-like 1Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-657
See related
Ensembl:ENSDARG00000105147 AllianceGenome:ZFIN:ZDB-GENE-050208-657
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-121a11.8
Summary
Predicted to enable cholesterol binding activity and sterol transporter activity. Predicted to act upstream of or within lipid transport. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Used to study visceral heterotaxy. Orthologous to human OSBPL1A (oxysterol binding protein like 1A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 22
Exon count:
29
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (16320015..16350847)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (16293749..16323324)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene tctex1 domain-containing protein 1-like Neighboring gene leucine rich repeat containing 39 Neighboring gene tRNA methyltransferase 13 homolog Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene laminin, alpha 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mixture-specific gene expression in zebrafish (Danio rerio) embryos exposed to perfluorooctane sulfonic acid (PFOS), perfluorohexanoic acid (PFHxA) and 3,3',4,4',5-pentachlorobiphenyl (PCB126). Blanc M, et al. Sci Total Environ, 2017 Jul 15. PMID 28283292
  2. A vertebrate model for the study of lipid binding/transfer protein function: conservation of OSBP-related proteins between zebrafish and human. Zhou Y, et al. Biochem Biophys Res Commun, 2014 Apr 11. PMID 24326072
  3. Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. Burkhalter MD, et al. J Clin Invest, 2019 May 16. PMID 31094706, Free PMC Article
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
oxysterol-binding protein-related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    16320015..16350847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469586.1 → XP_021325261.1  oxysterol-binding protein-related protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IQ17, A0A8M9Q392
    Related
    ENSDARP00000138426.1, ENSDART00000164161.2
    Conserved Domains (5) summary
    cd00204
    Location:44 → 216
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13285
    Location:232 → 356
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:564 → 956
    Oxysterol_BP; Oxysterol-binding protein
    cl26072
    Location:112 → 237
    Ank_5; Ankyrin repeats (many copies)

  2. XM_009296329.3 → XP_009294604.1  oxysterol-binding protein-related protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PQ26
    Conserved Domains (5) summary
    cd00204
    Location:44 → 216
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13285
    Location:232 → 356
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:564 → 949
    Oxysterol_BP; Oxysterol-binding protein
    cl26072
    Location:112 → 237
    Ank_5; Ankyrin repeats (many copies)

  3. XM_009296328.3 → XP_009294603.1  oxysterol-binding protein-related protein 1 isoform X1

    See identical proteins and their annotated locations for XP_009294603.1

    UniProtKB/TrEMBL
    A0A0R4IQ17, A0A8M9Q392
    Conserved Domains (5) summary
    cd00204
    Location:44 → 216
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13285
    Location:232 → 356
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:564 → 956
    Oxysterol_BP; Oxysterol-binding protein
    cl26072
    Location:112 → 237
    Ank_5; Ankyrin repeats (many copies)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395100.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    25163..55995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021473456.1 → XP_021329131.1  oxysterol-binding protein-related protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IQ17, A0A8M9Q392
    Conserved Domains (5) summary
    cd00204
    Location:44 → 216
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13285
    Location:232 → 356
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:564 → 956
    Oxysterol_BP; Oxysterol-binding protein
    cl26072
    Location:112 → 237
    Ank_5; Ankyrin repeats (many copies)

  2. XM_021473458.1 → XP_021329133.1  oxysterol-binding protein-related protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PQ26
    Conserved Domains (5) summary
    cd00204
    Location:44 → 216
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13285
    Location:232 → 356
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:564 → 949
    Oxysterol_BP; Oxysterol-binding protein
    cl26072
    Location:112 → 237
    Ank_5; Ankyrin repeats (many copies)

  3. XM_021473457.1 → XP_021329132.1  oxysterol-binding protein-related protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IQ17, A0A8M9Q392
    Conserved Domains (5) summary
    cd00204
    Location:44 → 216
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13285
    Location:232 → 356
    PH_ORP1; Human Oxysterol binding protein related protein 1 Pleckstrin homology (PH) domain
    sd00045
    Location:48 → 79
    ANK; ANK repeat [structural motif]
    pfam01237
    Location:564 → 956
    Oxysterol_BP; Oxysterol-binding protein
    cl26072
    Location:112 → 237
    Ank_5; Ankyrin repeats (many copies)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001045082.2: Suppressed sequence

    Description
    NM_001045082.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
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