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ppp3ccb protein phosphatase 3, catalytic subunit, gamma isozyme, b [ Danio rerio (zebrafish) ]

Gene ID: 565241, updated on 12-Sep-2024

Summary

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Official Symbol
ppp3ccbprovided by ZNC
Official Full Name
protein phosphatase 3, catalytic subunit, gamma isozyme, bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070112-1102
See related
Ensembl:ENSDARG00000057456 AllianceGenome:ZFIN:ZDB-GENE-070112-1102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7163784; zgc:158685
Summary
Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-mediated signaling. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in brain and head. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 10
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (20180154..20236434)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (20222755..20279124)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene dematin actin binding protein Neighboring gene 5-hydroxytryptamine (serotonin) receptor 7b Neighboring gene transcriptional and immune response regulator b Neighboring gene zinc finger, matrin-type 4b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development. Zhao J, et al. Elife, 2019 Jan 29. PMID 30694176, Free PMC Article
  2. Cabin1 expression suggests roles in neuronal development. Hammond DR, et al. Dev Dyn, 2010 Sep. PMID 20652955
  3. Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins. Kujawski S, et al. Dev Cell, 2014 Mar 10. PMID 24561038
  4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcineurin-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein phosphatase 3, catalytic subunit, gamma isozyme, b
NP_001074063.2
XP_005155370.1
XP_005155371.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080594.2 → NP_001074063.2  protein phosphatase 3, catalytic subunit, gamma isozyme, b

    Status: VALIDATED

    Source sequence(s)
    BC129382, CR381599, CR450836, DN898177, EB772264
    UniProtKB/TrEMBL
    A0A8N7UYL1, A1L277, F1QF86
    Related
    ENSDARP00000074466.4, ENSDART00000080016.5
    Conserved Domains (2) summary
    smart00156
    Location:55 → 326
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:38 → 342
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    20180154..20236434
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155313.5 → XP_005155370.1  protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1

    UniProtKB/TrEMBL
    A0A8M2B1V9, A1L277
    Conserved Domains (2) summary
    smart00156
    Location:55 → 326
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:38 → 342
    MPP_PP2B; PP2B, metallophosphatase domain

  2. XM_005155314.5 → XP_005155371.1  protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X2

    UniProtKB/TrEMBL
    A0A8M2B273, A1L277
    Conserved Domains (2) summary
    smart00156
    Location:55 → 326
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:38 → 342
    MPP_PP2B; PP2B, metallophosphatase domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394779.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    222970..264483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395287.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    91405..145945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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