U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

traf7 TNF receptor-associated factor 7 [ Danio rerio (zebrafish) ]

Gene ID: 563746, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
traf7provided by ZNC
Official Full Name
TNF receptor-associated factor 7provided by ZNC
Primary source
ZFIN:ZDB-GENE-070112-2212
See related
Ensembl:ENSDARG00000060207 AllianceGenome:ZFIN:ZDB-GENE-070112-2212
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7149067; zgc:158391
Summary
Predicted to enable ubiquitin ligase-substrate adaptor activity. Predicted to be involved in several processes, including protein polyubiquitination; proteolysis; and regulation of proteasomal protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human TRAF7 (TNF receptor associated factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See traf7 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
21
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (35608457..35637229)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (35478965..35505219)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene RNA pseudouridine synthase domain containing 1 Neighboring gene dynactin 5 Neighboring gene guanine nucleotide binding protein (G protein), gamma 13b Neighboring gene CASK interacting protein 1 Neighboring gene cytokine receptor-like factor 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease. Mishra-Gorur K, et al. Proc Natl Acad Sci U S A, 2023 Apr 18. PMID 37043537, Free PMC Article
  2. The viral TRAF protein (ORF111L) from infectious spleen and kidney necrosis virus interacts with TRADD and induces caspase 8-mediated apoptosis. He BL, et al. PLoS One, 2012. PMID 22615868, Free PMC Article
  3. Evolution of Class I cytokine receptors. Liongue C, et al. BMC Evol Biol, 2007 Jul 18. PMID 17640376, Free PMC Article
  4. Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish. Stein C, et al. Genome Biol, 2007. PMID 18039395, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease.
    Title: Pleiotropic role of TRAF7 in skull-base meningiomas and congenital heart disease.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC158391

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase TRAF7
NP_001073654.1
XP_009297828.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080185.1 → NP_001073654.1  E3 ubiquitin-protein ligase TRAF7

    See identical proteins and their annotated locations for NP_001073654.1

    Status: PROVISIONAL

    Source sequence(s)
    BC129220
    UniProtKB/TrEMBL
    A0A8M1NCR2, A1L1U9
    Related
    ENSDARP00000150464.1, ENSDART00000190995.1
    Conserved Domains (6) summary
    smart00184
    Location:100 → 132
    RING; Ring finger
    COG2319
    Location:349 → 637
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:357 → 637
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam14712
    Location:260 → 342
    Snapin_Pallidin; Snapin/Pallidin
    sd00039
    Location:368 → 406
    7WD40; WD40 repeat [structural motif]
    cl19105
    Location:141 → 249
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    35608457..35637229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009299553.2 → XP_009297828.1  E3 ubiquitin-protein ligase TRAF7 isoform X1

    See identical proteins and their annotated locations for XP_009297828.1

    UniProtKB/TrEMBL
    A0A8M1NCR2, A1L1U9
    Related
    ENSDARP00000119094.1, ENSDART00000132703.3
    Conserved Domains (6) summary
    smart00184
    Location:100 → 132
    RING; Ring finger
    COG2319
    Location:349 → 637
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:357 → 637
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    pfam14712
    Location:260 → 342
    Snapin_Pallidin; Snapin/Pallidin
    sd00039
    Location:368 → 406
    7WD40; WD40 repeat [structural motif]
    cl19105
    Location:141 → 249
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools