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Traf7 TNF receptor-associated factor 7 [ Mus musculus (house mouse) ]

Gene ID: 224619, updated on 23-Dec-2022

Summary

Official Symbol
Traf7provided by MGI
Official Full Name
TNF receptor-associated factor 7provided by MGI
Primary source
MGI:MGI:3042141
See related
Ensembl:ENSMUSG00000052752 AllianceGenome:MGI:3042141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RFWD1
Summary
Predicted to enable ubiquitin-protein transferase activity. Acts upstream of or within several processes, including cellular response to interleukin-6; negative regulation of transcription by RNA polymerase II; and positive regulation of protein sumoylation. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in genitourinary system and pancreas epithelium. Orthologous to human TRAF7 (TNF receptor associated factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 69.0), lung adult (RPKM 60.1) and 28 other tissues See more
Orthologs
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Genomic context

See Traf7 in Genome Data Viewer
Location:
17; 17 A3.3
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24727824..24746912, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24508850..24527938, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene phosphoglycolate phosphatase Neighboring gene BRICHOS domain containing 5 Neighboring gene MTOR associated protein, LST8 homolog (S. cerevisiae) Neighboring gene CASK interacting protein 1 Neighboring gene RAB26, member RAS oncogene family, opposite strand Neighboring gene small nucleolar RNA, C/D box 60 Neighboring gene RAB26, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC7807

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRAF7
Names
RING-type E3 ubiquitin transferase TRAF7
ring finger and WD repeat domain 1
NP_001165584.1
NP_001165585.1
NP_722487.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172113.2NP_001165584.1  E3 ubiquitin-protein ligase TRAF7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC132367
    Consensus CDS
    CCDS50014.1
    UniProtKB/TrEMBL
    F8WJF7
    Related
    ENSMUSP00000134759.2, ENSMUST00000176652.8
    Conserved Domains (6) summary
    cl17044
    Location:281321
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    smart00184
    Location:130162
    RING; Ring finger
    COG2319
    Location:379667
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:387667
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:442476
    7WD40; WD40 repeat [structural motif]
    cl19105
    Location:206279
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
  2. NM_001172114.2NP_001165585.1  E3 ubiquitin-protein ligase TRAF7 isoform 2

    See identical proteins and their annotated locations for NP_001165585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC132367
    Consensus CDS
    CCDS50015.1
    UniProtKB/TrEMBL
    Q8C2K8
    Related
    ENSMUSP00000135267.2, ENSMUST00000176353.8
    Conserved Domains (6) summary
    cl17044
    Location:241281
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    smart00184
    Location:92124
    RING; Ring finger
    COG2319
    Location:339627
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:347627
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:402436
    7WD40; WD40 repeat [structural motif]
    cl19105
    Location:168239
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
  3. NM_001415151.1NP_001402080.1  E3 ubiquitin-protein ligase TRAF7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132367
  4. NM_153792.2NP_722487.2  E3 ubiquitin-protein ligase TRAF7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and a downstream start codon, compared to variant 1. Isoform 3 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC132367
    Conserved Domains (6) summary
    cl17044
    Location:254294
    DD_cGKI; Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I
    smart00184
    Location:103135
    RING; Ring finger
    COG2319
    Location:352640
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:360640
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:415449
    7WD40; WD40 repeat [structural motif]
    cl19105
    Location:179252
    Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24727824..24746912 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)