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tenm1 teneurin transmembrane protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 563094, updated on 27-Mar-2024

Summary

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Official Symbol
tenm1provided by ZNC
Official Full Name
teneurin transmembrane protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-060531-26
See related
Ensembl:ENSDARG00000003403 AllianceGenome:ZFIN:ZDB-GENE-060531-26
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:ch211-1c4.1
Summary
Predicted to enable cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules and neuron development. Predicted to act upstream of or within signal transduction. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Is expressed in brain. Orthologous to human TENM1 (teneurin transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
33
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (21294520..21607665, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (20790720..21103853, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100536577 Neighboring gene SH2 domain containing 1A duplicate a Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 Neighboring gene GRB2 associated binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and Roles of Teneurins in Zebrafish. Cheung A, et al. Front Neurosci, 2019. PMID 30914911, Free PMC Article
  2. Angiotensin AT2 receptor activates the cyclic-AMP signaling pathway in eel. Wong MK, et al. Mol Cell Endocrinol, 2013 Jan 30. PMID 23174758
  3. Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability. Bengani H, et al. PLoS One, 2021. PMID 34388204, Free PMC Article
  4. New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Maugars G, et al. Front Endocrinol (Lausanne), 2020. PMID 33071966, Free PMC Article
  5. The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Postlethwait JH, et al. Biol Open, 2021 Mar 23. PMID 33757938, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
teneurin-1
Names
odz, odd Oz/ten-m homolog 1
odz1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    21294520..21607665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301392.3 → XP_009299667.1  teneurin-1 isoform X3

    UniProtKB/TrEMBL
    A0A8M3AZI7
    Conserved Domains (12) summary
    COG3209
    Location:1576 → 2415
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd00054
    Location:733 → 766
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd05819
    Location:1168 → 1203
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2324 → 2401
    Rhs_assc_core; RHS repeat-associated core domain
    cd00185
    Location:618 → 658
    TNFRSF; CRD2 [structural motif]
    pfam01500
    Location:602 → 740
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:92 → 294
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:511 → 537
    EGF_2; EGF-like domain
    pfam13620
    Location:860 → 933
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain
    pfam15636
    Location:2629 → 2704
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1139 → 1499
    NHL; NHL repeat unit of beta-propeller proteins
    cl22855
    Location:582 → 725
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  2. XM_009301391.3 → XP_009299666.1  teneurin-1 isoform X2

    UniProtKB/TrEMBL
    A0A8M3B2E0
    Related
    ENSDARP00000143435.2, ENSDART00000176793.2
    Conserved Domains (10) summary
    COG3209
    Location:1579 → 2418
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1178 → 1215
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2327 → 2404
    Rhs_assc_core; RHS repeat-associated core domain
    cd00185
    Location:618 → 658
    TNFRSF; CRD2 [structural motif]
    pfam06484
    Location:92 → 294
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:511 → 537
    EGF_2; EGF-like domain
    pfam13620
    Location:870 → 943
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain
    pfam15636
    Location:2632 → 2707
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1149 → 1502
    NHL; NHL repeat unit of beta-propeller proteins
    cl22855
    Location:582 → 725
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  3. XM_686460.9 → XP_691552.5  teneurin-1 isoform X1

    UniProtKB/TrEMBL
    A0A8N7UV98
    Related
    ENSDARP00000040183.7, ENSDART00000040184.7
    Conserved Domains (10) summary
    COG3209
    Location:1586 → 2425
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1178 → 1213
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2334 → 2411
    Rhs_assc_core; RHS repeat-associated core domain
    cd00185
    Location:618 → 658
    TNFRSF; CRD2 [structural motif]
    pfam06484
    Location:92 → 294
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:511 → 537
    EGF_2; EGF-like domain
    pfam13620
    Location:870 → 943
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain
    pfam15636
    Location:2639 → 2714
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1149 → 1509
    NHL; NHL repeat unit of beta-propeller proteins
    cl22855
    Location:582 → 725
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  4. XM_009301393.3 → XP_009299668.1  teneurin-1 isoform X4

    UniProtKB/TrEMBL
    A0A8M3AS74
    Conserved Domains (10) summary
    COG3209
    Location:1498 → 2337
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1090 → 1125
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:2246 → 2323
    Rhs_assc_core; RHS repeat-associated core domain
    cd00185
    Location:530 → 570
    TNFRSF; CRD2 [structural motif]
    pfam06484
    Location:39 → 206
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:423 → 449
    EGF_2; EGF-like domain
    pfam13620
    Location:782 → 855
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain
    pfam15636
    Location:2551 → 2626
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:1061 → 1421
    NHL; NHL repeat unit of beta-propeller proteins
    cl22855
    Location:494 → 637
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

  5. XM_009301394.3 → XP_009299669.1  teneurin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8M3B9J8
    Related
    ENSDARP00000113832.1, ENSDART00000144198.2
    Conserved Domains (9) summary
    COG3209
    Location:1249 → 2088
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:841 → 876
    NHL; NHL repeat [structural motif]
    TIGR03696
    Location:1997 → 2074
    Rhs_assc_core; RHS repeat-associated core domain
    cd00185
    Location:281 → 321
    TNFRSF; CRD2 [structural motif]
    pfam07974
    Location:174 → 200
    EGF_2; EGF-like domain
    pfam13620
    Location:533 → 606
    CarboxypepD_reg; Carboxypeptidase regulatory-like domain
    pfam15636
    Location:2302 → 2377
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:812 → 1172
    NHL; NHL repeat unit of beta-propeller proteins
    cl22855
    Location:245 → 388
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
Nucleotide Protein Strain
Heading Accession and Version

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