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TENM1 teneurin transmembrane protein 1 [ Homo sapiens (human) ]

Gene ID: 10178, updated on 12-Oct-2019

Summary

Official Symbol
TENM1provided by HGNC
Official Full Name
teneurin transmembrane protein 1provided by HGNC
Primary source
HGNC:HGNC:8117
See related
Ensembl:ENSG00000009694 MIM:300588
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNM; ODZ1; ODZ3; TEN1; TNM1; ten-1; TEN-M1
Summary
The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Expression
Broad expression in prostate (RPKM 2.1), brain (RPKM 2.0) and 17 other tissues See more
Orthologs

Genomic context

See TENM1 in Genome Data Viewer
Location:
Xq25
Exon count:
41
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (124375903..125204381, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (123509753..124097666, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373331 Neighboring gene TEX13 family member D Neighboring gene SH2 domain containing 1A Neighboring gene ribosomal protein S26 pseudogene 57 Neighboring gene filamin binding LIM protein 1 pseudogene Neighboring gene TEX13 family member C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
NHGRI GWA Catalog
Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates the expression of teneurin transmembrane protein 1 (TENM1; ODZ1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin binding TAS
Traceable Author Statement
more info
PubMed 
protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuron development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of filopodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of transcription by RNA polymerase III ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
teneurin-1
Names
odz (odd Oz/ten-m, Drosophila) homolog 3
odz, odd Oz/ten-m homolog 1(Drosophila)
protein Odd Oz/ten-m homolog 1
tenascin M1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013249.1 RefSeqGene

    Range
    5001..592914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001163278.1NP_001156750.1  teneurin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001156750.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF100772, AI498402, AK055765, AL022718, BC030766, BC140783, BX478232, CF454574
    Consensus CDS
    CCDS55488.1
    UniProtKB/Swiss-Prot
    Q9UKZ4
    Related
    ENSP00000403954.2, ENST00000422452.2
    Conserved Domains (10) summary
    COG3209
    Location:18252394
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:11971236
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:18521892
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23462424
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:529732
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:16441678
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23317
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:532558
    EGF_2; EGF-like domain
    pfam15636
    Location:26502725
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:11681528
    NHL; NHL repeat unit of beta-propeller proteins
  2. NM_001163279.1NP_001156751.1  teneurin-1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001156751.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame acceptor splice site at one of the coding exons compared to variant 1. This results in an isoform (2) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    AF100772, AI498402, AK055765, AL022718, BC030766, BC144543, BX478232, CF454574
    UniProtKB/Swiss-Prot
    Q9UKZ4
    UniProtKB/TrEMBL
    B7ZMH4
    Conserved Domains (10) summary
    COG3209
    Location:18242393
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:11961235
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:18511891
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23452423
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:528731
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:16431677
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23317
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:531557
    EGF_2; EGF-like domain
    pfam15636
    Location:26492724
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:11671527
    NHL; NHL repeat unit of beta-propeller proteins
  3. NM_014253.3NP_055068.2  teneurin-1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_055068.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (3) missing an internal 7 aa protein segment compared to isoform 1.
    Source sequence(s)
    AF100772, AI498402, AK055765, AL022718, BC030766, BC140783, BX478232, CF454574
    Consensus CDS
    CCDS14609.1
    UniProtKB/Swiss-Prot
    Q9UKZ4
    Related
    ENSP00000360171.3, ENST00000371130.7
    Conserved Domains (10) summary
    COG3209
    Location:18182387
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12411284
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:18451885
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23392417
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:529732
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:16371671
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23317
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:532558
    EGF_2; EGF-like domain
    pfam15636
    Location:26432718
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:11681521
    NHL; NHL repeat unit of beta-propeller proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    124375903..125204381 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029210.2XP_016884699.1  teneurin-1 isoform X1

  2. XM_017029211.2XP_016884700.1  teneurin-1 isoform X1

  3. XM_017029214.2XP_016884703.1  teneurin-1 isoform X3

    UniProtKB/Swiss-Prot
    Q9UKZ4
    Conserved Domains (10) summary
    COG3209
    Location:18182387
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12411284
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:18451885
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23392417
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:529732
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:16371671
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23317
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:532558
    EGF_2; EGF-like domain
    pfam15636
    Location:26432718
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:11681521
    NHL; NHL repeat unit of beta-propeller proteins
  4. XM_011531230.3XP_011529532.1  teneurin-1 isoform X2

    See identical proteins and their annotated locations for XP_011529532.1

    UniProtKB/Swiss-Prot
    Q9UKZ4
    Conserved Domains (10) summary
    COG3209
    Location:18252394
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:11971236
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:18521892
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23462424
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:529732
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam05593
    Location:16441678
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23317
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:532558
    EGF_2; EGF-like domain
    pfam15636
    Location:26502725
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:11681528
    NHL; NHL repeat unit of beta-propeller proteins
  5. XM_017029208.2XP_016884697.1  teneurin-1 isoform X1

  6. XM_017029209.2XP_016884698.1  teneurin-1 isoform X1

  7. XM_017029213.2XP_016884702.1  teneurin-1 isoform X1

  8. XM_017029212.2XP_016884701.1  teneurin-1 isoform X1

  9. XM_011531236.3XP_011529538.2  teneurin-1 isoform X4

  10. XM_011531237.3XP_011529539.1  teneurin-1 isoform X5

    Conserved Domains (7) summary
    COG3209
    Location:4931062
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:3978
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:520560
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:10141092
    Rhs_assc_core; RHS repeat-associated core domain
    pfam05593
    Location:312346
    RHS_repeat; RHS Repeat
    pfam15636
    Location:13181393
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:2196
    NHL; NHL repeat unit of beta-propeller proteins
  11. XM_017029216.2XP_016884705.1  teneurin-1 isoform X7

  12. XM_017029215.2XP_016884704.1  teneurin-1 isoform X6

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