ube3b ubiquitin protein ligase E3B [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ube3bprovided by ZNC
Official Full Name: ubiquitin protein ligase E3Bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060526-231
See related: Ensembl:ENSDARG00000061960 AllianceGenome:ZFIN:ZDB-GENE-060526-231
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-189p24.3
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Human ortholog(s) of this gene implicated in Kaufman oculocerebrofacial syndrome. Orthologous to human UBE3B (ubiquitin protein ligase E3B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (19445791..19473076)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (18941972..18969589)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein polyubiquitination	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ubiquitin-protein ligase E3B

NP_001108154.1

EC 2.3.2.26

XP_005165205.1

EC 2.3.2.26

XP_005165206.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114682.1 → NP_001108154.1 ubiquitin-protein ligase E3B

See identical proteins and their annotated locations for NP_001108154.1

Status: PROVISIONAL

Source sequence(s)

BX510366

UniProtKB/TrEMBL

A0A8N1YZY7, A2BGM8

Related

ENSDARP00000083401.5, ENSDART00000088968.6

Conserved Domains (3) summary

smart00015
Location:28 → 50

IQ; Calmodulin-binding motif

smart00119
Location:708 → 1066

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:683 → 1067

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

19445791..19473076

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165149.4 → XP_005165206.1 ubiquitin-protein ligase E3B isoform X1

See identical proteins and their annotated locations for XP_005165206.1

UniProtKB/TrEMBL

A0A8N1YZY7, A2BGM8

Conserved Domains (3) summary

smart00015
Location:28 → 50

IQ; Calmodulin-binding motif

smart00119
Location:708 → 1066

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:683 → 1067

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_005165148.4 → XP_005165205.1 ubiquitin-protein ligase E3B isoform X1

See identical proteins and their annotated locations for XP_005165205.1

UniProtKB/TrEMBL

A0A8N1YZY7, A2BGM8

Conserved Domains (3) summary

smart00015
Location:28 → 50

IQ; Calmodulin-binding motif

smart00119
Location:708 → 1066

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:683 → 1067

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...