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Ube3b ubiquitin protein ligase E3B [ Mus musculus (house mouse) ]

Gene ID: 117146, updated on 9-May-2024

Summary

Official Symbol
Ube3bprovided by MGI
Official Full Name
ubiquitin protein ligase E3Bprovided by MGI
Primary source
MGI:MGI:1891295
See related
Ensembl:ENSMUSG00000029577 AllianceGenome:MGI:1891295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Kaufman oculocerebrofacial syndrome. Orthologous to human UBE3B (ubiquitin protein ligase E3B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 52.8), adrenal adult (RPKM 51.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ube3b in Genome Data Viewer
Location:
5 F; 5 55.99 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (114518578..114559226)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (114380517..114421169)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene forkhead box N4 Neighboring gene VISTA enhancer mm1522 Neighboring gene myosin 1H Neighboring gene STARR-positive B cell enhancer mm9_chr5:114762243-114762544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:114765155-114765411 Neighboring gene potassium channel tetramerisation domain containing 10 Neighboring gene microRNA 7027 Neighboring gene STARR-positive B cell enhancer ABC_E278 Neighboring gene methylmalonic aciduria (cobalamin deficiency) cblB type homolog (human) Neighboring gene mevalonate kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse assembly IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
ubiquitin-protein ligase E3B
Names
HECT-type ubiquitin transferase E3B
NP_001318148.1
NP_001411684.1
NP_001411685.1
NP_001411686.1
NP_001411687.1
NP_473434.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331219.2NP_001318148.1  ubiquitin-protein ligase E3B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC132102
  2. NM_001424755.1NP_001411684.1  ubiquitin-protein ligase E3B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132102
    UniProtKB/Swiss-Prot
    Q8K068, Q9ES34
  3. NM_001424756.1NP_001411685.1  ubiquitin-protein ligase E3B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132102
  4. NM_001424757.1NP_001411686.1  ubiquitin-protein ligase E3B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC132102
  5. NM_001424758.1NP_001411687.1  ubiquitin-protein ligase E3B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC132102
  6. NM_054093.4NP_473434.2  ubiquitin-protein ligase E3B isoform 1

    See identical proteins and their annotated locations for NP_473434.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132102
    Consensus CDS
    CCDS19564.1
    UniProtKB/Swiss-Prot
    Q8K068, Q9ES34
    Related
    ENSMUSP00000073652.6, ENSMUST00000074002.12
    Conserved Domains (2) summary
    smart00119
    Location:7091067
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:6841068
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RNA

  1. NR_138602.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC132102
    Related
    ENSMUST00000130169.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    114518578..114559226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_387554.3 RNA Sequence