itih5 inter-alpha-trypsin inhibitor heavy chain 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itih5provided by ZNC
Official Full Name: inter-alpha-trypsin inhibitor heavy chain 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-041210-193
See related: Ensembl:ENSDARG00000045517 AllianceGenome:ZFIN:ZDB-GENE-041210-193
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-235i4.2
Summary: Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within hyaluronan metabolic process and negative regulation of peptidase activity. Predicted to be located in extracellular region. Orthologous to human ITIH5 (inter-alpha-trypsin inhibitor heavy chain 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (25220649..25245868)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (25231263..25256350)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within hyaluronan metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

Names: inter-alpha (globulin) inhibitor H5; inter-alpha-trypsin inhibitor heavy chain family, member 5

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The following sections contain reference sequences that belong to a specific genome build. Explain

XM_001331165.8 → XP_001331201.3 inter-alpha-trypsin inhibitor heavy chain H5 isoform X1

UniProtKB/TrEMBL

A0A8M1PU27

Related

ENSDARP00000116068.1, ENSDART00000138121.2

Conserved Domains (3) summary

pfam06668
Location:753 → 950

ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

pfam08487
Location:64 → 172

VIT; Vault protein inter-alpha-trypsin domain

cl00057
Location:308 → 491

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_068220778.1 → XP_068076879.1 inter-alpha-trypsin inhibitor heavy chain H5 isoform X2
XM_009300443.3 → XP_009298718.1 inter-alpha-trypsin inhibitor heavy chain H5 isoform X3

UniProtKB/TrEMBL

A0A8M3ARJ3

Conserved Domains (2) summary

pfam06668
Location:523 → 720

ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

cl00057
Location:78 → 261

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...