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Itih5 inter-alpha-trypsin inhibitor, heavy chain 5 [ Mus musculus (house mouse) ]

Gene ID: 209378, updated on 8-Feb-2024

Summary

Official Symbol
Itih5provided by MGI
Official Full Name
inter-alpha-trypsin inhibitor, heavy chain 5provided by MGI
Primary source
MGI:MGI:1925751
See related
Ensembl:ENSMUSG00000025780 AllianceGenome:MGI:1925751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E130106B02; 4631408O11Rik; 5430408M01Rik
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process. Predicted to act upstream of or within negative regulation of peptidase activity. Located in collagen-containing extracellular matrix. Is expressed in several structures, including genitourinary system; gut; limb segment; meninges; and sensory organ. Orthologous to human ITIH5 (inter-alpha-trypsin inhibitor heavy chain 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 41.5), subcutaneous fat pad adult (RPKM 34.7) and 16 other tissues See more
Orthologs
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Genomic context

See Itih5 in Genome Data Viewer
Location:
2 A1; 2 6.94 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (10158354..10261340)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (10153536..10256529)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene inter-alpha trypsin inhibitor, heavy chain 2 Neighboring gene STARR-seq mESC enhancer starr_03643 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:10236348-10236535 Neighboring gene predicted gene, 31496 Neighboring gene predicted gene, 39758

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inter-alpha-trypsin inhibitor heavy chain H5
Names
ITI heavy chain H5
ITI-HC5
inter-alpha (globulin) inhibitor H5
inter-alpha trypsin inhibitor heavy chain precursor 5
inter-alpha-inhibitor heavy chain 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172471.2NP_766059.1  inter-alpha-trypsin inhibitor heavy chain H5 precursor

    See identical proteins and their annotated locations for NP_766059.1

    Status: VALIDATED

    Source sequence(s)
    AK087428, AL953853, AW046694, BB595829
    Consensus CDS
    CCDS15678.1
    UniProtKB/Swiss-Prot
    Q3US68, Q80VG0, Q8BJD1
    Related
    ENSMUSP00000026886.8, ENSMUST00000026886.8
    Conserved Domains (4) summary
    cd01461
    Location:292473
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:65620
    marine_srt_targ; marine proteobacterial sortase target protein
    pfam06668
    Location:716909
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    pfam08487
    Location:51157
    VIT; Vault protein inter-alpha-trypsin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    10158354..10261340
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)