mtmr10 myotubularin related protein 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mtmr10provided by ZNC
Official Full Name: myotubularin related protein 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-061103-52
See related: Ensembl:ENSDARG00000010601 AllianceGenome:ZFIN:ZDB-GENE-061103-52
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb99a03; zgc:153233
Summary: Predicted to enable phosphatidylinositol-3-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm and membrane. Orthologous to human MTMR10 (myotubularin related protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (30725298..30771150)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (30454155..30497840)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: myotubularin-related protein 10

Names: inactive phosphatidylinositol 3-phosphatase 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001077597.2 → NP_001071065.2 myotubularin-related protein 10

Status: VALIDATED

Source sequence(s)

BX663518

UniProtKB/Swiss-Prot

A0JMF6

UniProtKB/TrEMBL

A0A8N1YZF7, F1Q8B7

Related

ENSDARP00000080151.4, ENSDART00000085716.7

Conserved Domains (3) summary

cd13346
Location:20 → 196

PH-GRAM_MTMR10; Myotubularian (MTM) related 10 protein (MTMR10) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

pfam12578
Location:553 → 676

3-PAP; Myotubularin-associated protein

cl21483
Location:208 → 483

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

30725298..30771150

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168881.4 → XP_005168938.1 myotubularin-related protein 10 isoform X1

UniProtKB/Swiss-Prot

A0JMF6

UniProtKB/TrEMBL

A0A8M2BG48, E7F1F0

Related

ENSDARP00000109082.2, ENSDART00000127131.3

Conserved Domains (3) summary

cd13346
Location:20 → 196

PH-GRAM_MTMR10; Myotubularian (MTM) related 10 protein (MTMR10) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

pfam12578
Location:566 → 689

3-PAP; Myotubularin-associated protein

cl21483
Location:208 → 496

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...