kpna5 karyopherin alpha 5 (importin alpha 6) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kpna5provided by ZNC
Official Full Name: karyopherin alpha 5 (importin alpha 6)provided by ZNC
Primary source: ZFIN:ZDB-GENE-050522-22
See related: Ensembl:ENSDARG00000042030 AllianceGenome:ZFIN:ZDB-GENE-050522-22
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: im:7151662; zgc:110662
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to act upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Orthologous to human KPNA5 (karyopherin subunit alpha 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: chromosome: 16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (32167430..32184457, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (32213400..32230427, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in NLS-bearing protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: importin subunit alpha-6

Names: karyopherin subunit alpha-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001018153.1 → NP_001018163.1 importin subunit alpha-6

See identical proteins and their annotated locations for NP_001018163.1

Status: PROVISIONAL

Source sequence(s)

BC095356

UniProtKB/Swiss-Prot

Q503E9

UniProtKB/TrEMBL

A0A0R4I9E5

Related

ENSDARP00000092803.4, ENSDART00000102027.5

Conserved Domains (6) summary

COG5064
Location:36 → 521

SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]

cd00020
Location:254 → 368

ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...

pfam01749
Location:9 → 105

IBB; Importin beta binding domain

pfam16186
Location:467 → 513

Arm_3; Atypical Arm repeat

sd00044
Location:88 → 117

HEAT; HEAT repeat [structural motif]

sd00043
Location:257 → 282

ARM; armadillo repeat [structural motif]