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pdha1 pyruvate dehydrogenase E1 alpha 1 subunit [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 549826, updated on 25-Apr-2024

Summary

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Official Symbol
pdha1provided by Xenbase
Official Full Name
pyruvate dehydrogenase E1 alpha 1 subunitprovided by Xenbase
Primary source
Xenbase:XB-GENE-952669
See related
Ensembl:ENSXETG00000006212
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
pdha; phe1a; pdha1-a; pdha1-b; pdhce1a
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (43230014..43241469)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (38914637..38926122)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene chromosome 2 Cxorf58 homolog Neighboring gene apolipoprotein O Neighboring gene kelch like family member 15 Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene SH3-domain kinase binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Names
pyruvate dehydrogenase (lipoamide) alpha 1
pyruvate dehydrogenase alpha 1
NP_001001197.1
NP_001017072.1
XP_012812481.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001197.1 → NP_001001197.1  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_001001197.1

    Status: PROVISIONAL

    Source sequence(s)
    BC067306
    UniProtKB/TrEMBL
    F6YKU6, Q6NX32
    Related
    ENSXETP00000054127.3, ENSXETT00000054127.4
    Conserved Domains (1) summary
    cl01629
    Location:68 → 348
    TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...

  2. NM_001017072.2 → NP_001017072.1  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001017072.1

    Status: PROVISIONAL

    Source sequence(s)
    CR761539
    UniProtKB/TrEMBL
    F6YKT8, F6YKU6, F7AKK3, Q28G62
    Related
    ENSXETP00000013649.5, ENSXETT00000013649.5
    Conserved Domains (1) summary
    TIGR03182
    Location:63 → 374
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    43230014..43241469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012957027.3 → XP_012812481.1  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8J0SFT1, F7CY70
    Related
    ENSXETP00000054128.3, ENSXETT00000054128.4
    Conserved Domains (1) summary
    TIGR03182
    Location:68 → 379
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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