Format

Send to:

Choose Destination

Pdha1 pyruvate dehydrogenase E1 alpha 1 [ Mus musculus (house mouse) ]

Gene ID: 18597, updated on 7-Apr-2019

Summary

Official Symbol
Pdha1provided by MGI
Official Full Name
pyruvate dehydrogenase E1 alpha 1provided by MGI
Primary source
MGI:MGI:97532
See related
Ensembl:ENSMUSG00000031299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdha-1
Expression
Ubiquitous expression in heart adult (RPKM 147.9), kidney adult (RPKM 68.4) and 26 other tissues See more
Orthologs

Genomic context

See Pdha1 in Genome Data Viewer
Location:
X F4; X 73.95 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (160122219..160138430, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (156560151..156576268, complement)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene SH3-domain kinase binding protein 1 Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene predicted gene, 39547 Neighboring gene predicted gene 15195 Neighboring gene predicted gene 15196

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
pyruvate dehydrogenase (NAD+) activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
pyruvate dehydrogenase (acetyl-transferring) activity ISO
Inferred from Sequence Orthology
more info
 
pyruvate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
pyruvate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
mitochondrial acetyl-CoA biosynthetic process from pyruvate IMP
Inferred from Mutant Phenotype
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
myelin sheath HDA PubMed 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Names
PDHE1-A type I
pyruvate dehydrogenase E1alpha subunit
NP_032836.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008810.3NP_032836.1  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor

    See identical proteins and their annotated locations for NP_032836.1

    Status: VALIDATED

    Source sequence(s)
    AK148459, BQ177075, BY783593
    Consensus CDS
    CCDS41195.1
    UniProtKB/Swiss-Prot
    P35486
    UniProtKB/TrEMBL
    Q3UFJ3
    Related
    ENSMUSP00000033662.8, ENSMUST00000033662.8
    Conserved Domains (1) summary
    TIGR03182
    Location:58370
    PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    160122219..160138430 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center