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CTNNB1 catenin beta 1 [ Bos taurus (cattle) ]

Gene ID: 539003, updated on 4-Apr-2024

Summary

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Official Symbol
CTNNB1provided by VGNC
Official Full Name
catenin beta 1provided by VGNC
Primary source
VGNC:VGNC:27802
See related
BGD:BT22729; Ensembl:ENSBTAG00000016420
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (13799069..13847827)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC132343484 Neighboring gene unc-51 like kinase 4 Neighboring gene trafficking kinesin protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The β-catenin signaling pathway stimulates bovine herpesvirus 1 productive infection. Zhu L, et al. Virology, 2017 Jan. PMID 27788397, Free PMC Article
  2. β-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1. Liu Y, et al. J Virol, 2016 Jan 6. PMID 26739046, Free PMC Article
  3. Trenbolone enhances myogenic differentiation by enhancing β-catenin signaling in muscle-derived stem cells of cattle. Zhao JX, et al. Domest Anim Endocrinol, 2011 May. PMID 21402455, Free PMC Article
  4. {beta}-Catenin regulates airway smooth muscle contraction. Jansen SR, et al. Am J Physiol Lung Cell Mol Physiol, 2010 Aug. PMID 20472712
  5. Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease? Kirton JP, et al. Circ Res, 2007 Sep 14. PMID 17673669

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells.
    Title: The β-catenin signaling pathway stimulates bovine herpesvirus 1 productive infection.
  2. These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production.
    Title: Protein kinase B is required for follicle-stimulating hormone mediated beta-catenin accumulation and estradiol production in granulosa cells of cattle.
  3. beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves.
    Title: β-Catenin, a Transcription Factor Activated by Canonical Wnt Signaling, Is Expressed in Sensory Neurons of Calves Latently Infected with Bovine Herpesvirus 1.
  4. These data demonstrate for the first time that FSH regulates CTNNB1 protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle.
    Title: Follicle-stimulating hormone regulation of estradiol production: possible involvement of WNT2 and β-catenin in bovine granulosa cells.
  5. These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle.
    Title: Trenbolone enhances myogenic differentiation by enhancing β-catenin signaling in muscle-derived stem cells of cattle.
  6. that beta-catenin is a plasma membrane-associated protein in airway smooth muscle that regulates active tension development, presumably by stabilizing cell-cell contacts and thereby supporting force transmission between neighboring cells.
    Title: {beta}-Catenin regulates airway smooth muscle contraction.
  7. cAMP/PKA regulation of GSK3beta/beta-catenin signaling contributes to the increase in progesterone production in corpus luteum.
    Title: Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis.
  8. This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin.
    Title: Beta-catenin localization and timing of early development of bovine embryos obtained from oocytes matured in the presence of follicle stimulating hormone.
  9. TGF-beta3 induces the chondrogenic differentiation of pericytes by inducing Wnt/beta-catenin signaling and T-cell factor-induced gene transcription.
    Title: Wnt/beta-catenin signaling stimulates chondrogenic and inhibits adipogenic differentiation of pericytes: potential relevance to vascular disease?
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC139922

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables alpha-catenin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein phosphatase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of catenin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
catenin beta-1
Names
beta-catenin
catenin (cadherin-associated protein), beta 1, 88kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001076141.1 → NP_001069609.1  catenin beta-1

    See identical proteins and their annotated locations for NP_001069609.1

    Status: PROVISIONAL

    Source sequence(s)
    BC119949
    UniProtKB/Swiss-Prot
    A7E3R2, Q0VCX4
    Related
    ENSBTAP00000021838.5, ENSBTAT00000021838.6
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    13799069..13847827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005222525.5 → XP_005222582.1  catenin beta-1 isoform X1

    See identical proteins and their annotated locations for XP_005222582.1

    UniProtKB/Swiss-Prot
    A7E3R2, Q0VCX4
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat

  2. XM_059879801.1 → XP_059735784.1  catenin beta-1 isoform X1

    UniProtKB/Swiss-Prot
    A7E3R2, Q0VCX4

  3. XM_005222524.5 → XP_005222581.1  catenin beta-1 isoform X1

    See identical proteins and their annotated locations for XP_005222581.1

    UniProtKB/Swiss-Prot
    A7E3R2, Q0VCX4
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat

  4. XM_059879803.1 → XP_059735786.1  catenin beta-1 isoform X1

    UniProtKB/Swiss-Prot
    A7E3R2, Q0VCX4

  5. XM_024982935.2 → XP_024838703.1  catenin beta-1 isoform X1

    UniProtKB/Swiss-Prot
    A7E3R2, Q0VCX4
    Conserved Domains (4) summary
    smart00185
    Location:350 → 390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142 → 431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402 → 427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583 → 622
    Arm; Armadillo/beta-catenin-like repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VCX4.1 GenPept UniProtKB/Swiss-Prot:Q0VCX4

Gene LinkOut

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