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CTNNB1 catenin beta 1 [ Homo sapiens (human) ]

Gene ID: 1499, updated on 26-Oct-2021

Summary

Official Symbol
CTNNB1provided by HGNC
Official Full Name
catenin beta 1provided by HGNC
Primary source
HGNC:HGNC:2514
See related
Ensembl:ENSG00000168036 MIM:116806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EVR7; CTNNB; MRD19; NEDSDV; armadillo
Summary
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in placenta (RPKM 94.7), thyroid (RPKM 78.7) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See CTNNB1 in Genome Data Viewer
Location:
3p22.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (41199422..41240445)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (41240996..41281934)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10354 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 1 Neighboring gene uncharacterized LOC105377046 Neighboring gene unc-51 like kinase 4 Neighboring gene rRNA-processing protein FCF1 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Colorectal cancer
MedGen: C0009402 OMIM: 114500 GeneReviews: Lynch Syndrome
Compare labs
Exudative vitreoretinopathy 7
MedGen: C4539767 OMIM: 617572 GeneReviews: Not available
Compare labs
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
GeneReviews: Not available
Hepatocellular carcinoma
MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
Compare labs
Medulloblastoma
MedGen: C0025149 OMIM: 155255 GeneReviews: Not available
Compare labs
Mental retardation, autosomal dominant 19
MedGen: C3554449 OMIM: 615075 GeneReviews: Not available
Compare labs
Neoplasm of ovary
MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
Compare labs
Pilomatrixoma
MedGen: C0206711 OMIM: 132600 GeneReviews: Not available
Compare labs
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
GeneReviews: Not available

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2017-11-22)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2017-11-22)

ClinGen Genome Curation PagePubMed

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Beta-catenin (CTNNB1) and transcription factor 4 (TCF4) by siRNA enhances HIV-1 transcription in astrocytes PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of beta-catenin in primary human osteoblasts PubMed
Nef nef HIV-1 NL4-3, SF2, NA7, and 8161k9 Nef alleles bind to CTNNB1 (b-catenin) in 293T cells and Jurkat T cells PubMed
nef HIV-1 Nef interacts with beta-catenin by a pull-down assay using purified recombinant proteins. The D186A and F191A mutations in Nef abrogate the binding PubMed
Tat tat HIV-1 Tat C induces phosphorylation of adherens junction proteins VE-cadherin and beta-catenin in human brain microvascular endothelial cells PubMed
tat TCF4 and beta-catenin proteins inhibit docking of HIV-1 Tat at the TAR region of the HIV-1 LTR PubMed
tat HIV-1 Tat-mediated downregulation of beta-catenin/Wnt signaling is dependent on the core and cysteine-rich domains of Tat. Clade C Tat lacks a dicysteine motif (C30C31) and does not downregulate beta-catenin signaling PubMed
tat HIV-1 Tat and methamphetamine downregulates beta-catenin signaling and also suppresses expression of LEF-1, a key partner of beta-catenin to regulate cognate gene expression PubMed
tat Axin1 regulates HIV-1 Tat-mediated transcription, which requires beta-catenin and TCF4 PubMed
Vpu vpu HIV-1 Vpu is a strong competitive inhibitor of beta-TrCP and impairs the degradation of SCF-beta-TrCP substrates such as IKBalpha, ATF4 and beta-catenin PubMed
vpu HIV-1 Vpu reduces the beta-catenin interaction with E-cadherin and the Vpu-mediated dissociation of beta-catenin with E-cadherin enhances particle release PubMed
vpu HIV-1 Vpu S61A mutant efficiently interacts with endogenous betaTrCP and strongly stabilizes beta-catenin PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1) at amino acid residues 46-47 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25606, FLJ37923, DKFZp686D02253

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables I-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables alpha-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables alpha-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cadherin binding HDA PubMed 
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables histone methyltransferase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor binding TAS
Traceable Author Statement
more info
PubMed 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coregulator binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
involved_in adherens junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterior/posterior axis specification IEA
Inferred from Electronic Annotation
more info
 
involved_in astrocyte-dopaminergic neuron signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in bone resorption IEA
Inferred from Electronic Annotation
more info
 
involved_in branching involved in blood vessel morphogenesis IC
Inferred by Curator
more info
PubMed 
involved_in branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IC
Inferred by Curator
more info
 
involved_in canonical Wnt signaling pathway involved in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in cell maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell morphogenesis involved in differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to indole-3-methanol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in central nervous system vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
involved_in cranial ganglion development IEA
Inferred from Electronic Annotation
more info
 
involved_in cranial skeletal system development IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of muscle stretch TAS
Traceable Author Statement
more info
PubMed 
involved_in dorsal root ganglion development IEA
Inferred from Electronic Annotation
more info
 
involved_in dorsal/ventral axis specification IEA
Inferred from Electronic Annotation
more info
 
involved_in ectoderm development IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic axis specification IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic foregut morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic heart tube development IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic skeletal limb joint morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endodermal cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in endothelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell differentiation involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial to mesenchymal transition TAS
Traceable Author Statement
more info
PubMed 
involved_in epithelial tube branching involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in fungiform papilla formation IEA
Inferred from Electronic Annotation
more info
 
involved_in gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
 
involved_in genitalia morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in glial cell fate determination IEA
Inferred from Electronic Annotation
more info
 
involved_in hair cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in hair follicle placode formation IEA
Inferred from Electronic Annotation
more info
 
involved_in hindbrain development IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in layer formation in cerebral cortex IEA
Inferred from Electronic Annotation
more info
 
involved_in lens morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
involved_in lung cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in lung induction IEA
Inferred from Electronic Annotation
more info
 
involved_in lung-associated mesenchyme development IEA
Inferred from Electronic Annotation
more info
 
involved_in male genitalia development IEA
Inferred from Electronic Annotation
more info
 
involved_in mesenchymal cell proliferation involved in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in metanephros morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in midbrain dopaminergic neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of mitotic cell cycle, embryonic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oxidative stress-induced neuron death IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nephron tubule formation IEA
Inferred from Electronic Annotation
more info
 
involved_in neural plate development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
involved_in oocyte development IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in oviduct development IEA
Inferred from Electronic Annotation
more info
 
involved_in pancreas development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of branching involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of core promoter binding IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of determination of dorsal identity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of epithelial cell proliferation involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of histone H3-K4 methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neuroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of telomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of positive regulation of telomere maintenance via telomerase ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription elongation from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proximal/distal pattern formation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of calcium ion import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of centriole-centriole cohesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of centromeric sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fibroblast proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of nephron tubule epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neurogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of secondary heart field cardioblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of timing of anagen IEA
Inferred from Electronic Annotation
more info
 
involved_in renal inner medulla development IEA
Inferred from Electronic Annotation
more info
 
involved_in renal outer medulla development IEA
Inferred from Electronic Annotation
more info
 
involved_in renal vesicle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
involved_in smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in stem cell population maintenance TAS
Traceable Author Statement
more info
PubMed 
involved_in sympathetic ganglion development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in synapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle clustering IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle transport IEA
Inferred from Electronic Annotation
more info
 
involved_in thymus development IEA
Inferred from Electronic Annotation
more info
 
involved_in trachea formation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
part_of Scrib-APC-beta-catenin complex IEA
Inferred from Electronic Annotation
more info
 
part_of Wnt signalosome NAS
Non-traceable Author Statement
more info
PubMed 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
 
located_in apicolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of beta-catenin-TCF complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of beta-catenin-TCF complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of beta-catenin-TCF7L2 complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell junction TAS
Traceable Author Statement
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in fascia adherens IEA
Inferred from Electronic Annotation
more info
 
part_of flotillin complex IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion HDA PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density, intracellular component IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic active zone cytoplasmic component IEA
Inferred from Electronic Annotation
more info
 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
catenin beta-1
Names
catenin (cadherin-associated protein), beta 1, 88kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013302.2 RefSeqGene

    Range
    5055..45993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1108

mRNA and Protein(s)

  1. NM_001098209.2NP_001091679.1  catenin beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001091679.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC104307, X87838
    Consensus CDS
    CCDS2694.1
    UniProtKB/Swiss-Prot
    P35222
    UniProtKB/TrEMBL
    A0A024R2Q3
    Related
    ENSP00000379488.3, ENST00000396185.8
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
  2. NM_001098210.2NP_001091680.1  catenin beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001091680.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC104307, DA216720, Z19054
    Consensus CDS
    CCDS2694.1
    UniProtKB/Swiss-Prot
    P35222
    UniProtKB/TrEMBL
    A0A024R2Q3
    Related
    ENSP00000379486.3, ENST00000396183.7
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
  3. NM_001330729.2NP_001317658.1  catenin beta-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC104307, AK294778, CA944934
    Consensus CDS
    CCDS87067.1
    UniProtKB/TrEMBL
    B4DGU4
    Related
    ENSP00000411226.1, ENST00000453024.6
    Conserved Domains (4) summary
    smart00185
    Location:343383
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:135424
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:395420
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:576615
    Arm; Armadillo/beta-catenin-like repeat
  4. NM_001904.4NP_001895.1  catenin beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001895.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC104307, X87838
    Consensus CDS
    CCDS2694.1
    UniProtKB/Swiss-Prot
    P35222
    UniProtKB/TrEMBL
    A0A024R2Q3
    Related
    ENSP00000344456.5, ENST00000349496.11
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    41199422..41240445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712983.2XP_006713046.1  catenin beta-1 isoform X2

    See identical proteins and their annotated locations for XP_006713046.1

    UniProtKB/TrEMBL
    B4DGU4
    Related
    ENSP00000495794.1, ENST00000644678.1
    Conserved Domains (4) summary
    smart00185
    Location:343383
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:135424
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:395420
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:576615
    Arm; Armadillo/beta-catenin-like repeat
  2. XM_024453360.1XP_024309128.1  catenin beta-1 isoform X2

    Related
    ENSP00000495426.1, ENST00000646116.1
    Conserved Domains (4) summary
    smart00185
    Location:343383
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:135424
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:395420
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:576615
    Arm; Armadillo/beta-catenin-like repeat
  3. XM_006712985.1XP_006713048.1  catenin beta-1 isoform X3

    Related
    ENSP00000496649.1, ENST00000644138.1
    Conserved Domains (3) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    cd00020
    Location:399518
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
  4. XM_024453356.1XP_024309124.1  catenin beta-1 isoform X1

    Related
    ENSP00000494053.1, ENST00000643977.1
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
  5. XM_024453358.1XP_024309126.1  catenin beta-1 isoform X1

    Related
    ENSP00000494914.1, ENST00000646369.1
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
  6. XM_024453359.1XP_024309127.1  catenin beta-1 isoform X2

    Related
    ENSP00000494780.1, ENST00000644524.1
    Conserved Domains (4) summary
    smart00185
    Location:343383
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:135424
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:395420
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:576615
    Arm; Armadillo/beta-catenin-like repeat
  7. XM_017005738.1XP_016861227.1  catenin beta-1 isoform X1

    UniProtKB/Swiss-Prot
    P35222
    UniProtKB/TrEMBL
    A0A024R2Q3
    Related
    ENSP00000409302.2, ENST00000450969.6
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
  8. XM_024453357.1XP_024309125.1  catenin beta-1 isoform X1

    Related
    ENSP00000495076.1, ENST00000642315.1
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    COG5064
    Location:142431
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
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