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CTNNB1 catenin beta 1 [ Homo sapiens (human) ]

Gene ID: 1499, updated on 1-Jun-2020

Summary

Official Symbol
CTNNB1provided by HGNC
Official Full Name
catenin beta 1provided by HGNC
Primary source
HGNC:HGNC:2514
See related
Ensembl:ENSG00000168036 MIM:116806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EVR7; CTNNB; MRD19; NEDSDV; armadillo
Summary
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Expression
Ubiquitous expression in placenta (RPKM 94.7), thyroid (RPKM 78.7) and 25 other tissues See more
Orthologs

Genomic context

See CTNNB1 in Genome Data Viewer
Location:
3p22.1
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (41199422..41240445)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (41236401..41281939)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10354 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 1 Neighboring gene uncharacterized LOC105377046 Neighboring gene unc-51 like kinase 4 Neighboring gene rRNA-processing protein FCF1 homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
EXUDATIVE VITREORETINOPATHY 7
MedGen: C4539767 OMIM: 617572 GeneReviews: Not available
Compare labs
Hepatocellular carcinoma
MedGen: C2239176 OMIM: 114550 GeneReviews: Not available
Compare labs
Medulloblastoma
MedGen: C0025149 OMIM: 155255 GeneReviews: Not available
Compare labs
Mental retardation, autosomal dominant 19
MedGen: C3554449 OMIM: 615075 GeneReviews: Not available
Compare labs
Neoplasm of ovary
MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
Compare labs
Pilomatrixoma
MedGen: C0206711 OMIM: 132600 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2017-11-22)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2017-11-22)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
NHGRI GWA Catalog
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of Beta-catenin (CTNNB1) and transcription factor 4 (TCF4) by siRNA enhances HIV-1 transcription in astrocytes PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of beta-catenin in primary human osteoblasts PubMed
Nef nef HIV-1 NL4-3, SF2, NA7, and 8161k9 Nef alleles bind to CTNNB1 (b-catenin) in 293T cells and Jurkat T cells PubMed
nef HIV-1 Nef interacts with beta-catenin by a pull-down assay using purified recombinant proteins. The D186A and F191A mutations in Nef abrogate the binding PubMed
Tat tat HIV-1 Tat C induces phosphorylation of adherens junction proteins VE-cadherin and beta-catenin in human brain microvascular endothelial cells PubMed
tat TCF4 and beta-catenin proteins inhibit docking of HIV-1 Tat at the TAR region of the HIV-1 LTR PubMed
tat HIV-1 Tat-mediated downregulation of beta-catenin/Wnt signaling is dependent on the core and cysteine-rich domains of Tat. Clade C Tat lacks a dicysteine motif (C30C31) and does not downregulate beta-catenin signaling PubMed
tat HIV-1 Tat and methamphetamine downregulates beta-catenin signaling and also suppresses expression of LEF-1, a key partner of beta-catenin to regulate cognate gene expression PubMed
tat Axin1 regulates HIV-1 Tat-mediated transcription, which requires beta-catenin and TCF4 PubMed
Vpu vpu HIV-1 Vpu is a strong competitive inhibitor of beta-TrCP and impairs the degradation of SCF-beta-TrCP substrates such as IKBalpha, ATF4 and beta-catenin PubMed
vpu HIV-1 Vpu reduces the beta-catenin interaction with E-cadherin and the Vpu-mediated dissociation of beta-catenin with E-cadherin enhances particle release PubMed
vpu HIV-1 Vpu S61A mutant efficiently interacts with endogenous betaTrCP and strongly stabilizes beta-catenin PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1) at amino acid residues 46-47 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25606, FLJ37923, DKFZp686D02253

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
I-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
alpha-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
androgen receptor binding NAS
Non-traceable Author Statement
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding HDA PubMed 
cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cadherin binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
disordered domain specific binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear hormone receptor binding TAS
Traceable Author Statement
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
T cell differentiation in thymus IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway, calcium modulating pathway TAS
Traceable Author Statement
more info
 
adherens junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
androgen receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
anterior/posterior axis specification IEA
Inferred from Electronic Annotation
more info
 
astrocyte-dopaminergic neuron signaling IEA
Inferred from Electronic Annotation
more info
 
beta-catenin destruction complex disassembly TAS
Traceable Author Statement
more info
 
beta-catenin-TCF complex assembly TAS
Traceable Author Statement
more info
 
bone resorption IEA
Inferred from Electronic Annotation
more info
 
branching involved in blood vessel morphogenesis IC
Inferred by Curator
more info
PubMed 
branching involved in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IC
Inferred by Curator
more info
 
canonical Wnt signaling pathway involved in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate specification IEA
Inferred from Electronic Annotation
more info
 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis involved in differentiation IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to indole-3-methanol IDA
Inferred from Direct Assay
more info
PubMed 
central nervous system vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
chromatin-mediated maintenance of transcription IEA
Inferred from Electronic Annotation
more info
 
cranial ganglion development IEA
Inferred from Electronic Annotation
more info
 
cranial skeletal system development IEA
Inferred from Electronic Annotation
more info
 
dorsal root ganglion development IEA
Inferred from Electronic Annotation
more info
 
dorsal/ventral axis specification IEA
Inferred from Electronic Annotation
more info
 
ectoderm development IEA
Inferred from Electronic Annotation
more info
 
embryonic axis specification IEA
Inferred from Electronic Annotation
more info
 
embryonic brain development IEA
Inferred from Electronic Annotation
more info
 
embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic foregut morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic heart tube development IEA
Inferred from Electronic Annotation
more info
 
embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal limb joint morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
endodermal cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
endothelial tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
entry of bacterium into host cell TAS
Traceable Author Statement
more info
 
epithelial cell differentiation involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
epithelial to mesenchymal transition TAS
Traceable Author Statement
more info
PubMed 
epithelial tube branching involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
fungiform papilla formation IEA
Inferred from Electronic Annotation
more info
 
gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
 
genitalia morphogenesis IEA
Inferred from Electronic Annotation
more info
 
glial cell fate determination IEA
Inferred from Electronic Annotation
more info
 
hair cell differentiation TAS
Traceable Author Statement
more info
PubMed 
hair follicle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
hair follicle placode formation IEA
Inferred from Electronic Annotation
more info
 
hindbrain development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
layer formation in cerebral cortex IEA
Inferred from Electronic Annotation
more info
 
lens morphogenesis in camera-type eye IEA
Inferred from Electronic Annotation
more info
 
lung cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lung induction IEA
Inferred from Electronic Annotation
more info
 
lung-associated mesenchyme development IEA
Inferred from Electronic Annotation
more info
 
male genitalia development IEA
Inferred from Electronic Annotation
more info
 
mesenchymal cell proliferation involved in lung development IEA
Inferred from Electronic Annotation
more info
 
metanephros morphogenesis IEA
Inferred from Electronic Annotation
more info
 
midbrain dopaminergic neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of mitotic cell cycle, embryonic ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oxidative stress-induced neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
nephron tubule formation IEA
Inferred from Electronic Annotation
more info
 
neural plate development IEA
Inferred from Electronic Annotation
more info
 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
neuron projection extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
oocyte development IEA
Inferred from Electronic Annotation
more info
 
osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
oviduct development IEA
Inferred from Electronic Annotation
more info
 
pancreas development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-templated transcription, initiation IC
Inferred by Curator
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of chromatin-mediated maintenance of transcription IEA
Inferred from Electronic Annotation
more info
 
positive regulation of core promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of determination of dorsal identity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial cell proliferation involved in prostate gland development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epithelial to mesenchymal transition IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone H3-K4 methylation IC
Inferred by Curator
more info
PubMed 
positive regulation of mesenchymal cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of muscle cell differentiation TAS
Traceable Author Statement
more info
 
positive regulation of neuroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomerase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
proximal/distal pattern formation IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of angiogenesis TAS
Traceable Author Statement
more info
PubMed 
regulation of calcium ion import IDA
Inferred from Direct Assay
more info
PubMed 
regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
 
regulation of centriole-centriole cohesion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of centromeric sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of euchromatin binding IEA
Inferred from Electronic Annotation
more info
 
regulation of fibroblast proliferation TAS
Traceable Author Statement
more info
PubMed 
regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
regulation of nephron tubule epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of neurogenesis TAS
Traceable Author Statement
more info
PubMed 
regulation of protein localization to cell surface IDA
Inferred from Direct Assay
more info
PubMed 
regulation of secondary heart field cardioblast proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of timing of anagen IEA
Inferred from Electronic Annotation
more info
 
renal inner medulla development IEA
Inferred from Electronic Annotation
more info
 
renal outer medulla development IEA
Inferred from Electronic Annotation
more info
 
renal vesicle formation IEA
Inferred from Electronic Annotation
more info
 
response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IDA
Inferred from Direct Assay
more info
PubMed 
smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance TAS
Traceable Author Statement
more info
PubMed 
sympathetic ganglion development ISS
Inferred from Sequence or Structural Similarity
more info
 
synapse organization IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle clustering IEA
Inferred from Electronic Annotation
more info
 
synaptic vesicle transport IEA
Inferred from Electronic Annotation
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
trachea formation IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
Scrib-APC-beta-catenin complex IEA
Inferred from Electronic Annotation
more info
 
Wnt signalosome NAS
Non-traceable Author Statement
more info
PubMed 
Z disc IEA
Inferred from Electronic Annotation
more info
 
adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin destruction complex IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin-TCF complex IDA
Inferred from Direct Assay
more info
PubMed 
beta-catenin-TCF complex IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin-TCF7L2 complex IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catenin complex IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell junction TAS
Traceable Author Statement
more info
PubMed 
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
fascia adherens IEA
Inferred from Electronic Annotation
more info
 
flotillin complex IEA
Inferred from Electronic Annotation
more info
 
focal adhesion HDA PubMed 
lamellipodium IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
microvillus membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
postsynaptic density, intracellular component IEA
Inferred from Electronic Annotation
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
presynaptic active zone cytoplasmic component IEA
Inferred from Electronic Annotation
more info
 
presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
protein-DNA complex IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 
synapse ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
catenin beta-1
Names
catenin (cadherin-associated protein), beta 1, 88kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013302.2 RefSeqGene

    Range
    5055..45993
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098209.2NP_001091679.1  catenin beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001091679.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC104307, X87838
    Consensus CDS
    CCDS2694.1
    UniProtKB/Swiss-Prot
    P35222
    UniProtKB/TrEMBL
    A0A024R2Q3
    Related
    ENSP00000379488.3, ENST00000396185.8
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:142431
    Arm_3; Atypical Arm repeat
  2. NM_001098210.2NP_001091680.1  catenin beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001091680.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC104307, DA216720, Z19054
    Consensus CDS
    CCDS2694.1
    UniProtKB/Swiss-Prot
    P35222
    UniProtKB/TrEMBL
    A0A024R2Q3
    Related
    ENSP00000379486.3, ENST00000396183.7
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:142431
    Arm_3; Atypical Arm repeat
  3. NM_001330729.2NP_001317658.1  catenin beta-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC104307, AK294778, CA944934
    Consensus CDS
    CCDS87067.1
    UniProtKB/TrEMBL
    B4DGU4
    Related
    ENSP00000411226.1, ENST00000453024.6
    Conserved Domains (4) summary
    smart00185
    Location:343383
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:576615
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:395420
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:135424
    Arm_3; Atypical Arm repeat
  4. NM_001904.4NP_001895.1  catenin beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001895.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC104307, X87838
    Consensus CDS
    CCDS2694.1
    UniProtKB/Swiss-Prot
    P35222
    UniProtKB/TrEMBL
    A0A024R2Q3
    Related
    ENSP00000344456.5, ENST00000349496.11
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:142431
    Arm_3; Atypical Arm repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    41199422..41240445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712983.2XP_006713046.1  catenin beta-1 isoform X2

    See identical proteins and their annotated locations for XP_006713046.1

    UniProtKB/TrEMBL
    B4DGU4
    Related
    ENSP00000495794.1, ENST00000644678.1
    Conserved Domains (4) summary
    smart00185
    Location:343383
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:576615
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:395420
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:135424
    Arm_3; Atypical Arm repeat
  2. XM_024453360.1XP_024309128.1  catenin beta-1 isoform X2

    Related
    ENSP00000495426.1, ENST00000646116.1
    Conserved Domains (4) summary
    smart00185
    Location:343383
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:576615
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:395420
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:135424
    Arm_3; Atypical Arm repeat
  3. XM_006712985.1XP_006713048.1  catenin beta-1 isoform X3

    Related
    ENSP00000496649.1, ENST00000644138.1
    Conserved Domains (3) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    cd00020
    Location:399518
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
  4. XM_024453356.1XP_024309124.1  catenin beta-1 isoform X1

    Related
    ENSP00000494053.1, ENST00000643977.1
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:142431
    Arm_3; Atypical Arm repeat
  5. XM_024453358.1XP_024309126.1  catenin beta-1 isoform X1

    Related
    ENSP00000494914.1, ENST00000646369.1
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:142431
    Arm_3; Atypical Arm repeat
  6. XM_024453359.1XP_024309127.1  catenin beta-1 isoform X2

    Related
    ENSP00000494780.1, ENST00000644524.1
    Conserved Domains (4) summary
    smart00185
    Location:343383
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:576615
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:395420
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:135424
    Arm_3; Atypical Arm repeat
  7. XM_017005738.1XP_016861227.1  catenin beta-1 isoform X1

    UniProtKB/Swiss-Prot
    P35222
    UniProtKB/TrEMBL
    A0A024R2Q3
    Related
    ENSP00000409302.2, ENST00000450969.6
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:142431
    Arm_3; Atypical Arm repeat
  8. XM_024453357.1XP_024309125.1  catenin beta-1 isoform X1

    Related
    ENSP00000495076.1, ENST00000642315.1
    Conserved Domains (4) summary
    smart00185
    Location:350390
    ARM; Armadillo/beta-catenin-like repeats
    pfam00514
    Location:583622
    Arm; Armadillo/beta-catenin-like repeat
    sd00043
    Location:402427
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:142431
    Arm_3; Atypical Arm repeat
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