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RET ret proto-oncogene [ Bos taurus (domestic cattle) ]

Gene ID: 515924, updated on 17-Aug-2024

Summary

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Official Symbol
RETprovided by VGNC
Official Full Name
ret proto-oncogeneprovided by VGNC
Primary source
VGNC:VGNC:33876
See related
Ensembl:ENSBTAG00000000570
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See RET in Genome Data Viewer
Location:
chromosome: 28
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 28 NC_037355.1 (13467125..13524201)

Chromosome 28 - NC_037355.1Genomic Context describing neighboring genes Neighboring gene BMS1 ribosome biogenesis factor Neighboring gene protein lin-28 homolog A-like Neighboring gene chondroitin sulfate N-acetylgalactosaminyltransferase 2 Neighboring gene RasGEF domain family member 1A Neighboring gene uncharacterized LOC132344126

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037355.1 Chromosome 28 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
proto-oncogene tyrosine-protein kinase receptor Ret
NP_001178412.1
XP_024842420.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191483.1 → NP_001178412.1  proto-oncogene tyrosine-protein kinase receptor Ret precursor

    Status: VALIDATED

    Source sequence(s)
    BC149315, NKLS02000028
    UniProtKB/TrEMBL
    A0AAA9S761
    Related
    ENSBTAP00000081836.1, ENSBTAT00000110777.1
    Conserved Domains (3) summary
    cd05045
    Location:723 → 1012
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    pfam00028
    Location:172 → 260
    Cadherin; Cadherin domain
    pfam07714
    Location:724 → 1005
    Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037355.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    13467125..13524201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024986652.2 → XP_024842420.1  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1

    UniProtKB/TrEMBL
    A0AAA9S761, F1MS00
    Related
    ENSBTAP00000000744.6, ENSBTAT00000000744.7
    Conserved Domains (2) summary
    cd05045
    Location:723 → 1012
    PTKc_RET; Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein
    pfam00028
    Location:172 → 260
    Cadherin; Cadherin domain
Nucleotide Protein Strain
Heading Accession and Version

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