GRK4 G protein-coupled receptor kinase 4 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: GRK4provided by VGNC
Official Full Name: G protein-coupled receptor kinase 4provided by VGNC
Primary source: VGNC:VGNC:29655
See related: BGD:BT28347; Ensembl:ENSBTAG00000001505
Gene type: protein coding
RefSeq status: MODEL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	6	NC_037333.1 (115732041..115790299, complement)

Chromosome 6 - NC_037333.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

PRL (e-PCR)
- UniSTS:253903

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables G protein-coupled receptor kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: G protein-coupled receptor kinase 4

XP_010804644.1

EC 2.7.1.-

EC 2.7.11.16

XP_010804650.1

EC 2.7.1.-

EC 2.7.11.16

XP_015327228.1

EC 2.7.1.-

EC 2.7.11.16

XP_024849494.2

EC 2.7.1.-

EC 2.7.11.16

XP_024849505.2

EC 2.7.1.-

EC 2.7.11.16

XP_024849506.2

EC 2.7.1.-

EC 2.7.11.16

XP_024849507.2

EC 2.7.1.-

EC 2.7.11.16

XP_024849508.2

EC 2.7.1.-

EC 2.7.11.16

XP_059743850.1

EC 2.7.1.-

EC 2.7.11.16

XP_059743851.1

EC 2.7.1.-

EC 2.7.11.16

XP_059743852.1

EC 2.7.1.-

EC 2.7.11.16

XP_059743853.1

EC 2.7.1.-

EC 2.7.11.16

XP_059743854.1

EC 2.7.1.-

EC 2.7.11.16

XP_059743855.1

EC 2.7.1.-

EC 2.7.11.16

XP_059743856.1

EC 2.7.1.-

EC 2.7.11.16

XP_059743857.1

EC 2.7.1.-

EC 2.7.11.16

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

Range

115732041..115790299 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024993740.2 → XP_024849508.2 G protein-coupled receptor kinase 4 isoform X14
XM_010806342.4 → XP_010804644.1 G protein-coupled receptor kinase 4 isoform X3

UniProtKB/TrEMBL

A0A3Q1MYX1

Related

ENSBTAP00000061327.1, ENSBTAT00000079631.2

Conserved Domains (3) summary

smart00220
Location:187 → 462

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05605
Location:186 → 483

STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases

cl02565
Location:52 → 184

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_059887868.1 → XP_059743851.1 G protein-coupled receptor kinase 4 isoform X1
XM_010806348.4 → XP_010804650.1 G protein-coupled receptor kinase 4 isoform X10

See identical proteins and their annotated locations for XP_010804650.1

UniProtKB/TrEMBL

A0A3Q1MYX1

Conserved Domains (2) summary

cd05605
Location:154 → 451

STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases

cl02565
Location:20 → 152

RGS; Regulator of G protein signaling (RGS) domain superfamily
XM_059887867.1 → XP_059743850.1 G protein-coupled receptor kinase 4 isoform X1
XM_059887872.1 → XP_059743855.1 G protein-coupled receptor kinase 4 isoform X7
XM_059887870.1 → XP_059743853.1 G protein-coupled receptor kinase 4 isoform X4
XM_024993739.2 → XP_024849507.2 G protein-coupled receptor kinase 4 isoform X13

Related

ENSBTAP00000087206.1, ENSBTAT00000115080.1
XM_059887874.1 → XP_059743857.1 G protein-coupled receptor kinase 4 isoform X9
XM_059887869.1 → XP_059743852.1 G protein-coupled receptor kinase 4 isoform X2

UniProtKB/TrEMBL

F1MN48

Related

ENSBTAP00000073454.2, ENSBTAT00000076355.2
XM_024993737.2 → XP_024849505.2 G protein-coupled receptor kinase 4 isoform X11
XM_059887873.1 → XP_059743856.1 G protein-coupled receptor kinase 4 isoform X8
XM_024993738.2 → XP_024849506.2 G protein-coupled receptor kinase 4 isoform X12

Related

ENSBTAP00000064244.2, ENSBTAT00000085872.2
XM_024993726.2 → XP_024849494.2 G protein-coupled receptor kinase 4 isoform X6

Related

ENSBTAP00000090651.1, ENSBTAT00000122126.1
XM_059887871.1 → XP_059743854.1 G protein-coupled receptor kinase 4 isoform X5
XM_015471742.3 → XP_015327228.1 G protein-coupled receptor kinase 4 isoform X10

UniProtKB/TrEMBL

A0A3Q1MYX1

Conserved Domains (2) summary

cd05605
Location:154 → 451

STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases

cl02565
Location:20 → 152

RGS; Regulator of G protein signaling (RGS) domain superfamily