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Oaz2 ornithine decarboxylase antizyme 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501454, updated on 2-Nov-2024

Summary

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Symbol
Oaz2provided by RGD
Full Name
ornithine decarboxylase antizyme 2provided by RGD
Primary source
RGD:1562933
See related
EnsemblRapid:ENSRNOG00000015953 AllianceGenome:RGD:1562933
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1562933
Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Expression
Biased expression in Muscle (RPKM 830.8), Heart (RPKM 637.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Oaz2 in Genome Data Viewer
Location:
8q24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75094817..75108634)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66199694..66213513)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71216011..71229788)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene PIF1 5'-to-3' DNA helicase Neighboring gene RNA binding protein, mRNA processing factor 2 Neighboring gene uncharacterized LOC103693122 Neighboring gene zinc finger protein 609 Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene U6 spliceosomal RNA Neighboring gene PCNA clamp associated factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The antizyme family: polyamines and beyond. Mangold U. IUBMB Life, 2005 Oct. PMID 16223706
  2. Evidence of a role for antizyme and antizyme inhibitor as regulators of human cancer. Olsen RR, et al. Mol Cancer Res, 2011 Oct. PMID 21849468, Free PMC Article
  3. Antizyme inhibitor 2 (AZIN2/ODCp) stimulates polyamine uptake in mammalian cells. López-Contreras AJ, et al. J Biol Chem, 2008 Jul 25. PMID 18508777, Free PMC Article
  4. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. Kanerva K, et al. Biochem J, 2008 Jan 1. PMID 17900240
  5. Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity. López-Contreras AJ, et al. J Biol Chem, 2006 Oct 13. PMID 16916800

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ornithine decarboxylase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ornithine decarboxylase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in negative regulation of polyamine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in viral translational frameshifting IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ornithine decarboxylase antizyme 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109899.2 → NP_001103369.1  ornithine decarboxylase antizyme 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BQ195681, FQ134463, FQ211793
    UniProtKB/TrEMBL
    A0A8I6A353
    Related
    ENSRNOP00000087417.1, ENSRNOT00000099651.2
    Conserved Domains (1) summary
    pfam02100
    Location:100 → 181
    ODC_AZ; Ornithine decarboxylase antizyme

  2. NM_001301297.1 → NP_001288226.1  ornithine decarboxylase antizyme 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.
    Source sequence(s)
    BQ195681, FQ134463, FQ211793
    UniProtKB/TrEMBL
    A0A8I6A353, F1M7B5
    Conserved Domains (1) summary
    pfam02100
    Location:97 → 180
    ODC_AZ; Ornithine decarboxylase antizyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    75094817..75108634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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