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OAZ2 ornithine decarboxylase antizyme 2 [ Homo sapiens (human) ]

Gene ID: 4947, updated on 1-Jun-2020

Summary

Official Symbol
OAZ2provided by HGNC
Official Full Name
ornithine decarboxylase antizyme 2provided by HGNC
Primary source
HGNC:HGNC:8096
See related
Ensembl:ENSG00000180304 MIM:604152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AZ2
Summary
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamines. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in brain (RPKM 48.0), spleen (RPKM 41.8) and 25 other tissues See more
Orthologs

Genomic context

See OAZ2 in Genome Data Viewer
Location:
15q22.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (64687574..64703281, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (64979773..64995462, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 609 Neighboring gene uncharacterized LOC101930091 Neighboring gene ribosomal protein L21 pseudogene 15 Neighboring gene RNA, U6 small nuclear 549, pseudogene Neighboring gene uncharacterized LOC107984737 Neighboring gene RNA binding protein, mRNA processing factor 2 Neighboring gene microRNA 1272

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ornithine decarboxylase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ornithine decarboxylase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of polyamine transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
polyamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
polyamine metabolic process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of intracellular protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cellular amino acid metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ornithine decarboxylase antizyme 2
Names
ODC-Az 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301302.1NP_001288231.1  ornithine decarboxylase antizyme 2 isoform 2

    See identical proteins and their annotated locations for NP_001288231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.
    Source sequence(s)
    BC035493, BG059726, BI597670, DA210449
    Conserved Domains (1) summary
    pfam02100
    Location:97180
    ODC_AZ; Ornithine decarboxylase antizyme
  2. NM_002537.3NP_002528.1  ornithine decarboxylase antizyme 2 isoform 1

    See identical proteins and their annotated locations for NP_002528.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC035493, BG059726, DA210449
    Consensus CDS
    CCDS58372.1
    UniProtKB/Swiss-Prot
    O95190
    Related
    ENSP00000463013.1, ENST00000326005.10
    Conserved Domains (1) summary
    pfam02100
    Location:93181
    ODC_AZ; Ornithine decarboxylase antizyme

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    64687574..64703281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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