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Mob2 MOB kinase activator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499288, updated on 18-Sep-2024

Summary

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Official Symbol
Mob2provided by RGD
Official Full Name
MOB kinase activator 2provided by RGD
Primary source
RGD:1562983
See related
EnsemblRapid:ENSRNOG00000020044 AllianceGenome:RGD:1562983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hcca2; RGD1562983
Summary
Predicted to enable protein kinase activator activity. Predicted to be involved in positive regulation of protein phosphorylation and signal transduction. Predicted to act upstream of or within actin cytoskeleton organization and positive regulation of neuron projection development. Predicted to be located in cytosol; neuron projection terminus; and nuclear lumen. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB2 (MOB kinase activator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 214.5), Muscle (RPKM 201.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q41
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (206522523..206579502, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (197092991..197149978, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214953992..214962106, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene toll interacting protein Neighboring gene uncharacterized LOC134485203 Neighboring gene BR serine/threonine kinase 2 Neighboring gene dual specificity phosphatase 8 Neighboring gene keratin associated protein 5-5 like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mps one binder 2 gene upregulation in the stellation of astrocytes induced by cAMP-dependent pathway. Fang KM, et al. J Cell Biochem, 2012 Sep. PMID 22566124
  2. The promotion of neurite formation in Neuro2A cells by mouse Mob2 protein. Lin CH, et al. FEBS Lett, 2011 Feb 4. PMID 21237165
  3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that Mob2 is involved in PKA signaling-mediated astrocytic stellation.
    Title: Mps one binder 2 gene upregulation in the stellation of astrocytes induced by cAMP-dependent pathway.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection terminus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MOB kinase activator 2
Names
Mps one binder kinase activator-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109159.2 → NP_001102629.1  MOB kinase activator 2

    See identical proteins and their annotated locations for NP_001102629.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6ABE4, A6HY34
    Related
    ENSRNOP00000091325.2, ENSRNOT00000118667.2
    Conserved Domains (1) summary
    pfam03637
    Location:32 → 200
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    206522523..206579502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087879.2 → XP_038943807.1  MOB kinase activator 2 isoform X5

    Conserved Domains (1) summary
    pfam03637
    Location:32 → 140
    Mob1_phocein; Mob1/phocein family

  2. XM_039087874.2 → XP_038943802.1  MOB kinase activator 2 isoform X4

    Conserved Domains (1) summary
    pfam03637
    Location:5 → 115
    Mob1_phocein; Mob1/phocein family

  3. XM_039087872.2 → XP_038943800.1  MOB kinase activator 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ABE4
    Related
    ENSRNOP00000027195.6, ENSRNOT00000027195.8
    Conserved Domains (1) summary
    pfam03637
    Location:30 → 198
    Mob1_phocein; Mob1/phocein family

  4. XM_039087871.2 → XP_038943799.1  MOB kinase activator 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABE4, A6HY35, D3ZLX3
    Related
    ENSRNOP00000108107.1, ENSRNOT00000128983.1
    Conserved Domains (1) summary
    pfam03637
    Location:63 → 231
    Mob1_phocein; Mob1/phocein family

  5. XM_039087873.2 → XP_038943801.1  MOB kinase activator 2 isoform X3

    Conserved Domains (1) summary
    pfam03637
    Location:63 → 171
    Mob1_phocein; Mob1/phocein family
Nucleotide Protein Strain
Heading Accession and Version

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