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MOB2 MOB kinase activator 2 [ Homo sapiens (human) ]

Gene ID: 81532, updated on 13-Mar-2020

Summary

Official Symbol
MOB2provided by HGNC
Official Full Name
MOB kinase activator 2provided by HGNC
Primary source
HGNC:HGNC:24904
See related
Ensembl:ENSG00000182208 MIM:611969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCCA2
Annotation information
Annotation category: partial on reference assembly
Expression
Ubiquitous expression in skin (RPKM 12.1), endometrium (RPKM 11.8) and 25 other tissues See more
Orthologs

Genomic context

See MOB2 in Genome Data Viewer
Location:
11p15.5
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (1469448..1486779, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1490685..1507948, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BR serine/threonine kinase 2 Neighboring gene uncharacterized LOC107984298 Neighboring gene uncharacterized LOC105376514 Neighboring gene dual specificity phosphatase 8 Neighboring gene KRTAP5-1/KRTAP5-2 antisense RNA 1 Neighboring gene keratin associated protein 5-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
neuron projection terminus IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MOB kinase activator 2
Names
MOB2 Mps One Binder homolog
Mps one binder kinase activator-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172223.3NP_001165694.1  MOB kinase activator 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC091196, AK296658, AW874617, BC047291, DC413532
    Consensus CDS
    CCDS53591.1
    UniProtKB/Swiss-Prot
    Q70IA6
    Related
    ENSP00000328694.6, ENST00000329957.7
    Conserved Domains (1) summary
    pfam03637
    Location:63231
    Mob1_phocein; Mob1/phocein family
  2. NM_053005.5NP_443731.2  MOB kinase activator 2 isoform 2

    See identical proteins and their annotated locations for NP_443731.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AW874617, BC047291, BC067785, BP388313, DC413532, HY032250
    UniProtKB/Swiss-Prot
    Q70IA6
    Related
    ENSP00000479647.2, ENST00000614710.5
    Conserved Domains (1) summary
    pfam03637
    Location:32200
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    1469448..1486779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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