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MOB2 MOB kinase activator 2 [ Homo sapiens (human) ]

Gene ID: 81532, updated on 6-Sep-2022

Summary

Official Symbol
MOB2provided by HGNC
Official Full Name
MOB kinase activator 2provided by HGNC
Primary source
HGNC:HGNC:24904
See related
Ensembl:ENSG00000182208 MIM:611969; AllianceGenome:HGNC:24904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCCA2
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Expression
Ubiquitous expression in skin (RPKM 12.1), endometrium (RPKM 11.8) and 25 other tissues See more
Orthologs
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Genomic context

See MOB2 in Genome Data Viewer
Location:
11p15.5
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1469448..1486779, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1543884..1615049, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1490678..1508009, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2689 Neighboring gene BR serine/threonine kinase 2 Neighboring gene uncharacterized LOC124902607 Neighboring gene uncharacterized LOC124902608 Neighboring gene dual specificity phosphatase 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
MOB kinase activator 2
Names
MOB2 Mps One Binder homolog
Mps one binder kinase activator-like 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172223.3NP_001165694.1  MOB kinase activator 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC091196, AK296658, AW874617, BC047291, DC413532
    Consensus CDS
    CCDS53591.1
    UniProtKB/Swiss-Prot
    Q70IA6
    Related
    ENSP00000328694.6, ENST00000329957.7
    Conserved Domains (1) summary
    pfam03637
    Location:63231
    Mob1_phocein; Mob1/phocein family
  2. NM_053005.5NP_443731.2  MOB kinase activator 2 isoform 2

    See identical proteins and their annotated locations for NP_443731.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AW874617, BC047291, BC067785, BP388313, DC413532, HY032250
    UniProtKB/Swiss-Prot
    Q70IA6, Q96M67
    Conserved Domains (1) summary
    pfam03637
    Location:32200
    Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    1469448..1486779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791792.1 Reference GRCh38.p14 PATCHES

    Range
    203714..274494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    1543884..1615049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)