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PDK2 pyruvate dehydrogenase kinase 2 [ Canis lupus familiaris (dog) ]

Gene ID: 491075, updated on 17-Aug-2024

Summary

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Official Symbol
PDK2provided by VGNC
Official Full Name
pyruvate dehydrogenase kinase 2provided by VGNC
Primary source
VGNC:VGNC:44381
See related
Ensembl:ENSCAFG00845012105
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See PDK2 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
12
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (26893879..26910588)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (25492516..25509234)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (26050254..26066966)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (25661663..25678380)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (25920287..25937009)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119873286 Neighboring gene integrin subunit alpha 3 Neighboring gene sterile alpha motif domain containing 14 Neighboring gene uncharacterized LOC111097376 Neighboring gene protein phosphatase 1 regulatory subunit 9B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial; pyruvate dehydrogenase kinase, isozyme 2
XP_005624690.1
XP_005624691.1
XP_013972110.1
XP_022278809.1
XP_038341803.1
XP_038341804.1
XP_038341805.1
XP_038341806.1
XP_038341807.1
XP_038403563.1
XP_038403564.1
XP_038403565.1
XP_038403566.1
XP_038403567.1
XP_038467563.1
XP_038467564.1
XP_038467565.1
XP_038467566.1
XP_038467567.1
XP_038532760.1
XP_038532761.1
XP_038532762.1
XP_038532763.1
XP_038532764.1
XP_548195.3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    26893879..26910588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038676836.1 → XP_038532764.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X5

    Conserved Domains (2) summary
    cd16929
    Location:139 → 305
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:1 → 135
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  2. XM_038676834.1 → XP_038532762.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LHK9, A0A8C0R9P9, A0A8I3NK58
    Related
    ENSCAFP00845016922.1, ENSCAFT00845021532.1
    Conserved Domains (2) summary
    cd16929
    Location:196 → 362
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  3. XM_038676835.1 → XP_038532763.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X4

    UniProtKB/TrEMBL
    A0A8P0NIF7
    Conserved Domains (2) summary
    cd16929
    Location:196 → 361
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  4. XM_038676832.1 → XP_038532760.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X1

    Conserved Domains (2) summary
    cd16929
    Location:203 → 369
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 199
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  5. XM_038676833.1 → XP_038532761.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X2

    Conserved Domains (2) summary
    cd16929
    Location:203 → 368
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 199
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    25661663..25678380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038485879.1 → XP_038341807.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X5

    Conserved Domains (2) summary
    cd16929
    Location:139 → 305
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:1 → 135
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  2. XM_038485877.1 → XP_038341805.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X3

    Conserved Domains (2) summary
    cd16929
    Location:196 → 362
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  3. XM_038485878.1 → XP_038341806.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X4

    Conserved Domains (2) summary
    cd16929
    Location:196 → 361
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  4. XM_038485875.1 → XP_038341803.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X1

    Conserved Domains (2) summary
    cd16929
    Location:203 → 369
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 199
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  5. XM_038485876.1 → XP_038341804.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X2

    Conserved Domains (2) summary
    cd16929
    Location:203 → 368
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 199
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    25920287..25937009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038611639.1 → XP_038467567.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X5

    Conserved Domains (2) summary
    cd16929
    Location:139 → 305
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:1 → 135
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  2. XM_038611637.1 → XP_038467565.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X3

    Conserved Domains (2) summary
    cd16929
    Location:196 → 362
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  3. XM_038611638.1 → XP_038467566.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X4

    Conserved Domains (2) summary
    cd16929
    Location:196 → 361
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  4. XM_038611635.1 → XP_038467563.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X1

    Conserved Domains (2) summary
    cd16929
    Location:203 → 369
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 199
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  5. XM_038611636.1 → XP_038467564.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X2

    Conserved Domains (2) summary
    cd16929
    Location:203 → 368
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 199
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    26050254..26066966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038547639.1 → XP_038403567.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X5

    Conserved Domains (2) summary
    cd16929
    Location:139 → 305
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:1 → 135
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  2. XM_038547637.1 → XP_038403565.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LHK9, A0A8C0R9P9, A0A8I3NK58
    Conserved Domains (2) summary
    cd16929
    Location:196 → 362
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  3. XM_038547638.1 → XP_038403566.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X4

    UniProtKB/TrEMBL
    A0A8P0NIF7
    Conserved Domains (2) summary
    cd16929
    Location:196 → 361
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  4. XM_038547635.1 → XP_038403563.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X1

    Conserved Domains (2) summary
    cd16929
    Location:203 → 369
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 199
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  5. XM_038547636.1 → XP_038403564.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X2

    Conserved Domains (2) summary
    cd16929
    Location:203 → 368
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 199
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    25492516..25509234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022423101.2 → XP_022278809.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X5

    Conserved Domains (2) summary
    cd16929
    Location:139 → 305
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:1 → 135
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  2. XM_005624634.4 → XP_005624691.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LHK9, A0A8C0R9P9, A0A8I3NK58
    Conserved Domains (2) summary
    cd16929
    Location:196 → 362
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  3. XM_548195.7 → XP_548195.3  pyruvate dehydrogenase kinase, isozyme 2 isoform X4

    UniProtKB/TrEMBL
    A0A8P0NIF7
    Conserved Domains (2) summary
    cd16929
    Location:196 → 361
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 192
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  4. XM_005624633.4 → XP_005624690.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X1

    Conserved Domains (2) summary
    cd16929
    Location:203 → 369
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 199
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase

  5. XM_014116635.3 → XP_013972110.1  pyruvate dehydrogenase kinase, isozyme 2 isoform X2

    Conserved Domains (2) summary
    cd16929
    Location:203 → 368
    HATPase_PDK-like; Histidine kinase-like ATPase domain of pyruvate dehydrogenase kinase, branched-chain alpha-ketoacid dehydrogenase kinase and related domains
    pfam10436
    Location:30 → 199
    BCDHK_Adom3; Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
Nucleotide Protein
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