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FLT3 fms related receptor tyrosine kinase 3 [ Canis lupus familiaris (dog) ]

Gene ID: 486025, updated on 17-Aug-2024

Summary

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Official Symbol
FLT3provided by VGNC
Official Full Name
fms related receptor tyrosine kinase 3provided by VGNC
Primary source
VGNC:VGNC:40908
See related
Ensembl:ENSCAFG00845024412
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See FLT3 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
32
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (11678532..11799840)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (11657250..11733707)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (11653606..11730223)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (11617543..11693992)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (11610080..11686320)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene fms related receptor tyrosine kinase 1 Neighboring gene poly(A) specific ribonuclease subunit PAN3 Neighboring gene dynein light chain roadblock-type 1 pseudogene Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FLT3 mutations in canine acute lymphocytic leukemia. Suter SE, et al. BMC Cancer, 2011 Jan 27. PMID 21272320, Free PMC Article
  2. RAS, FLT3, and C-KIT mutations in immunophenotyped canine leukemias. Usher SG, et al. Exp Hematol, 2009 Jan. PMID 18977066
  3. Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs. Zavodovskaya R, et al. Am J Vet Res, 2006 Apr. PMID 16579756

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that ALL and FLT3 biology is conserved between canine and human patients.
    Title: FLT3 mutations in canine acute lymphocytic leukemia.
  2. RAS, FLT3, and C-KIT mutations, analogous to those found in human leukemia, occur commonly in acute canine leukemia.
    Title: RAS, FLT3, and C-KIT mutations in immunophenotyped canine leukemias.
  3. Dysregulation of Kit/SCF, Flt3/Flt3L, and Met/HGF signaling pathways is unlikely to occur in histiocytic sarcomas of dogs.
    Title: Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein kinase FLT3
Names
fms related tyrosine kinase 3
NP_001018647.1
XP_038290482.1
XP_038290483.1
XP_038290484.1
XP_038290485.1
XP_038290486.1
XP_038290487.1
XP_038290488.1
XP_038290489.1
XP_038290490.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020811.1 → NP_001018647.1  receptor-type tyrosine-protein kinase FLT3 precursor

    See identical proteins and their annotated locations for NP_001018647.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ007998
    UniProtKB/TrEMBL
    A0A8C0RPR4, A0A8C0T4N7, A0A8I3PNJ1, Q4ZHV8
    Related
    ENSCAFP00845034543.1, ENSCAFT00845044088.1
    Conserved Domains (2) summary
    pfam00047
    Location:256 → 345
    ig; Immunoglobulin domain
    cl21453
    Location:572 → 947
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    11678532..11799840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038434556.1 → XP_038290484.1  receptor-type tyrosine-protein kinase FLT3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LMI3
    Conserved Domains (3) summary
    pfam00047
    Location:262 → 351
    ig; Immunoglobulin domain
    cd00096
    Location:266 → 270
    Ig; Ig strand A' [structural motif]
    cl21453
    Location:578 → 953
    PKc_like; Protein Kinases, catalytic domain

  2. XM_038434555.1 → XP_038290483.1  receptor-type tyrosine-protein kinase FLT3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LMI3
    Conserved Domains (3) summary
    pfam00047
    Location:262 → 351
    ig; Immunoglobulin domain
    cd00096
    Location:266 → 270
    Ig; Ig strand A' [structural motif]
    cl21453
    Location:578 → 953
    PKc_like; Protein Kinases, catalytic domain

  3. XM_038434554.1 → XP_038290482.1  receptor-type tyrosine-protein kinase FLT3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LMI3
    Conserved Domains (3) summary
    pfam00047
    Location:262 → 351
    ig; Immunoglobulin domain
    cd00096
    Location:266 → 270
    Ig; Ig strand A' [structural motif]
    cl21453
    Location:578 → 953
    PKc_like; Protein Kinases, catalytic domain

  4. XM_038434561.1 → XP_038290489.1  receptor-type tyrosine-protein kinase FLT3 isoform X4

    UniProtKB/TrEMBL
    A0A8C0LMI3, A0A8C0NYJ4, A0A8I3PMS8, A0A8P0TSX1
    Conserved Domains (3) summary
    pfam00047
    Location:237 → 326
    ig; Immunoglobulin domain
    cd00096
    Location:241 → 245
    Ig; Ig strand A' [structural motif]
    cl21453
    Location:553 → 928
    PKc_like; Protein Kinases, catalytic domain

  5. XM_038434559.1 → XP_038290487.1  receptor-type tyrosine-protein kinase FLT3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NYJ4, A0A8I3PWT7, A0A8P0NT43
    Related
    ENSCAFP00845034214.1, ENSCAFT00845043670.1
    Conserved Domains (3) summary
    pfam00047
    Location:245 → 334
    ig; Immunoglobulin domain
    cd00096
    Location:249 → 253
    Ig; Ig strand A' [structural motif]
    cl21453
    Location:561 → 936
    PKc_like; Protein Kinases, catalytic domain

  6. XM_038434557.1 → XP_038290485.1  receptor-type tyrosine-protein kinase FLT3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LMI3
    Conserved Domains (3) summary
    pfam00047
    Location:262 → 351
    ig; Immunoglobulin domain
    cd00096
    Location:266 → 270
    Ig; Ig strand A' [structural motif]
    cl21453
    Location:578 → 953
    PKc_like; Protein Kinases, catalytic domain

  7. XM_038434558.1 → XP_038290486.1  receptor-type tyrosine-protein kinase FLT3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LMI3
    Conserved Domains (3) summary
    pfam00047
    Location:262 → 351
    ig; Immunoglobulin domain
    cd00096
    Location:266 → 270
    Ig; Ig strand A' [structural motif]
    cl21453
    Location:578 → 953
    PKc_like; Protein Kinases, catalytic domain

  8. XM_038434562.1 → XP_038290490.1  receptor-type tyrosine-protein kinase FLT3 isoform X4

    UniProtKB/TrEMBL
    A0A8C0LMI3, A0A8C0NYJ4, A0A8I3PMS8, A0A8P0TSX1
    Related
    ENSCAFP00845033941.1, ENSCAFT00845043307.1
    Conserved Domains (3) summary
    pfam00047
    Location:237 → 326
    ig; Immunoglobulin domain
    cd00096
    Location:241 → 245
    Ig; Ig strand A' [structural motif]
    cl21453
    Location:553 → 928
    PKc_like; Protein Kinases, catalytic domain

  9. XM_038434560.1 → XP_038290488.1  receptor-type tyrosine-protein kinase FLT3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0LMI3
    Conserved Domains (3) summary
    pfam00047
    Location:262 → 351
    ig; Immunoglobulin domain
    cd00096
    Location:266 → 270
    Ig; Ig strand A' [structural motif]
    cl21453
    Location:578 → 953
    PKc_like; Protein Kinases, catalytic domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    11617543..11693992
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    11610080..11686320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    11653606..11730223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    11657250..11733707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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