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FLT3 fms related receptor tyrosine kinase 3 [ Homo sapiens (human) ]

Gene ID: 2322, updated on 21-Feb-2021

Summary

Official Symbol
FLT3provided by HGNC
Official Full Name
fms related receptor tyrosine kinase 3provided by HGNC
Primary source
HGNC:HGNC:3765
See related
Ensembl:ENSG00000122025 MIM:136351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FLK2; STK1; CD135; FLK-2
Summary
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]
Expression
Broad expression in spleen (RPKM 4.2), lymph node (RPKM 3.7) and 16 other tissues See more
Orthologs
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Genomic context

See FLT3 in Genome Data Viewer
Location:
13q12.2
Exon count:
27
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (28003274..28100587, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (28577411..28674713, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370132 Neighboring gene RNA, 7SL, cytoplasmic 272, pseudogene Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase Neighboring gene katanin regulatory subunit B1 like 1 pseudogene 1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2 pseudogene 8 Neighboring gene PAN3 antisense RNA 1 Neighboring gene poly(A) specific ribonuclease subunit PAN3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cytokine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
glucocorticoid receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
vascular endothelial growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
MAPK cascade TAS
Traceable Author Statement
more info
 
animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
cellular response to cytokine stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
PubMed 
cellular response to glucocorticoid stimulus IEA
Inferred from Electronic Annotation
more info
 
common myeloid progenitor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
dendritic cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
lymphocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myeloid progenitor cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of MAP kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
PubMed 
positive regulation of tyrosine phosphorylation of STAT protein TAS
Traceable Author Statement
more info
PubMed 
pro-B cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein autophosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vascular endothelial growth factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein kinase FLT3
Names
CD135 antigen
FL cytokine receptor
fetal liver kinase 2
fms related tyrosine kinase 3
fms-like tyrosine kinase 3
growth factor receptor tyrosine kinase type III
stem cell tyrosine kinase 1
NP_004110.2
XP_011533317.1
XP_011533319.1
XP_011533320.1
XP_016875975.1
XP_016875976.1
XP_016875977.1
XP_016875978.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007066.1 RefSeqGene

    Range
    4977..102295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_457

mRNA and Protein(s)

  1. NM_004119.3NP_004110.2  receptor-type tyrosine-protein kinase FLT3 precursor

    See identical proteins and their annotated locations for NP_004110.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein.
    Source sequence(s)
    AL356915, AL591024, AW057705, BI461248, U02687, Z26652
    Consensus CDS
    CCDS31953.1
    UniProtKB/Swiss-Prot
    P36888
    Related
    ENSP00000241453.7, ENST00000241453.12
    Conserved Domains (3) summary
    pfam00047
    Location:256345
    ig; Immunoglobulin domain
    pfam07714
    Location:610943
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:572947
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_130706.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon as used in variant 1 renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL356915, AL445262, AW057705, AW772610, BC036028
    Related
    ENST00000380987.2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    28003274..28100587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020486.1XP_016875975.1  receptor-type tyrosine-protein kinase FLT3 isoform X2

  2. XM_017020489.1XP_016875978.1  receptor-type tyrosine-protein kinase FLT3 isoform X5

  3. XM_017020487.1XP_016875976.1  receptor-type tyrosine-protein kinase FLT3 isoform X3

    Conserved Domains (3) summary
    pfam00047
    Location:81170
    ig; Immunoglobulin domain
    pfam07714
    Location:435768
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:397772
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017020488.1XP_016875977.1  receptor-type tyrosine-protein kinase FLT3 isoform X4

  5. XM_011535015.2XP_011533317.1  receptor-type tyrosine-protein kinase FLT3 isoform X1

    Conserved Domains (3) summary
    pfam00047
    Location:237326
    ig; Immunoglobulin domain
    pfam07714
    Location:591924
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:553928
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011535017.2XP_011533319.1  receptor-type tyrosine-protein kinase FLT3 isoform X3

    See identical proteins and their annotated locations for XP_011533319.1

    Conserved Domains (3) summary
    pfam00047
    Location:81170
    ig; Immunoglobulin domain
    pfam07714
    Location:435768
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:397772
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011535018.2XP_011533320.1  receptor-type tyrosine-protein kinase FLT3 isoform X3

    See identical proteins and their annotated locations for XP_011533320.1

    Conserved Domains (3) summary
    pfam00047
    Location:81170
    ig; Immunoglobulin domain
    pfam07714
    Location:435768
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:397772
    PKc_like; Protein Kinases, catalytic domain
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