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BCAR3 BCAR3 adaptor protein, NSP family member [ Canis lupus familiaris (dog) ]

Gene ID: 479941, updated on 5-Mar-2024

Summary

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Official Symbol
BCAR3provided by VGNC
Official Full Name
BCAR3 adaptor protein, NSP family memberprovided by VGNC
Primary source
VGNC:VGNC:49077
See related
Ensembl:ENSCAFG00845015973
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See BCAR3 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
17
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 6 NC_051810.1 (55743759..55899988)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 6 NC_006588.4 (58076009..58232203)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 6 NC_049227.1 (55861300..56017521)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 6 NC_049266.1 (55423562..55579644)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 6 NC_049747.1 (55408217..55564415)

Chromosome 6 - NC_051810.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111096389 Neighboring gene uncharacterized LOC119872267 Neighboring gene transfer RNA arginine (anticodon UCU) Neighboring gene uncharacterized LOC111096393 Neighboring gene uncharacterized LOC111096392 Neighboring gene formin binding protein 1 like Neighboring gene eukaryotic translation initiation factor 2-alpha kinase 1-like Neighboring gene down-regulator of transcription 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer anti-estrogen resistance protein 3
Names
BCAR3, NSP family adaptor protein
breast cancer anti-estrogen resistance 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051810.1 Reference ROS_Cfam_1.0

    Range
    55743759..55899988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038670077.1 → XP_038526005.1  breast cancer anti-estrogen resistance protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N0H9, A0A8I3NP71, A0A8P0T468
    Related
    ENSCAFP00845022430.1, ENSCAFT00845028514.1
    Conserved Domains (2) summary
    cd10337
    Location:147 → 274
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:535 → 810
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  2. XM_038670079.1 → XP_038526007.1  breast cancer anti-estrogen resistance protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N0H9, A0A8I3NP71, A0A8P0T468
    Related
    ENSCAFP00845022349.1, ENSCAFT00845028410.1
    Conserved Domains (2) summary
    cd10337
    Location:147 → 274
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:535 → 810
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. XM_038670078.1 → XP_038526006.1  breast cancer anti-estrogen resistance protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N0H9, A0A8I3NP71, A0A8P0T468
    Conserved Domains (2) summary
    cd10337
    Location:147 → 274
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:535 → 810
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_038670080.1 → XP_038526008.1  breast cancer anti-estrogen resistance protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KGC2, A0A8C0Q1X1, A0A8C0Q4T6, A0A8I3P3I3, A0A8I3P6Y6, A0A8P0SP04
    Related
    ENSCAFP00845022487.1, ENSCAFT00845028579.1
    Conserved Domains (2) summary
    cd10337
    Location:56 → 183
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:444 → 719
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  5. XM_038670081.1 → XP_038526009.1  breast cancer anti-estrogen resistance protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q6I2
    Conserved Domains (1) summary
    cl02485
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  6. XM_038670082.1 → XP_038526010.1  breast cancer anti-estrogen resistance protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q6I2
    Conserved Domains (1) summary
    cl02485
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049266.1 Alternate UMICH_Zoey_3.1

    Range
    55423562..55579644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038480009.1 → XP_038335937.1  breast cancer anti-estrogen resistance protein 3 isoform X1

  2. XM_038480011.1 → XP_038335939.1  breast cancer anti-estrogen resistance protein 3 isoform X1

  3. XM_038480010.1 → XP_038335938.1  breast cancer anti-estrogen resistance protein 3 isoform X1

  4. XM_038480012.1 → XP_038335940.1  breast cancer anti-estrogen resistance protein 3 isoform X2

    Conserved Domains (2) summary
    cd10337
    Location:56 → 183
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:444 → 719
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  5. XM_038480013.1 → XP_038335941.1  breast cancer anti-estrogen resistance protein 3 isoform X3

    Conserved Domains (1) summary
    cl02485
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  6. XM_038480014.1 → XP_038335942.1  breast cancer anti-estrogen resistance protein 3 isoform X3

    Conserved Domains (1) summary
    cl02485
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049747.1 Alternate UNSW_CanFamBas_1.0

    Range
    55408217..55564415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038605443.1 → XP_038461371.1  breast cancer anti-estrogen resistance protein 3 isoform X1

  2. XM_038605445.1 → XP_038461373.1  breast cancer anti-estrogen resistance protein 3 isoform X1

  3. XM_038605444.1 → XP_038461372.1  breast cancer anti-estrogen resistance protein 3 isoform X1

  4. XM_038605446.1 → XP_038461374.1  breast cancer anti-estrogen resistance protein 3 isoform X2

    Conserved Domains (2) summary
    cd10337
    Location:56 → 183
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:444 → 719
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  5. XM_038605447.1 → XP_038461375.1  breast cancer anti-estrogen resistance protein 3 isoform X3

    Conserved Domains (1) summary
    cl02485
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  6. XM_038605448.1 → XP_038461376.1  breast cancer anti-estrogen resistance protein 3 isoform X3

    Conserved Domains (1) summary
    cl02485
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049227.1 Alternate UU_Cfam_GSD_1.0

    Range
    55861300..56017521
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038541304.1 → XP_038397232.1  breast cancer anti-estrogen resistance protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N0H9, A0A8I3NP71, A0A8P0T468
    Conserved Domains (2) summary
    cd10337
    Location:147 → 274
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:535 → 810
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  2. XM_038541306.1 → XP_038397234.1  breast cancer anti-estrogen resistance protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N0H9, A0A8I3NP71, A0A8P0T468
    Conserved Domains (2) summary
    cd10337
    Location:147 → 274
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:535 → 810
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. XM_038541305.1 → XP_038397233.1  breast cancer anti-estrogen resistance protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N0H9, A0A8I3NP71, A0A8P0T468
    Conserved Domains (2) summary
    cd10337
    Location:147 → 274
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:535 → 810
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_038541307.1 → XP_038397235.1  breast cancer anti-estrogen resistance protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KGC2, A0A8C0Q1X1, A0A8C0Q4T6, A0A8I3P3I3, A0A8I3P6Y6, A0A8P0SP04
    Conserved Domains (2) summary
    cd10337
    Location:56 → 183
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:444 → 719
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  5. XM_038541308.1 → XP_038397236.1  breast cancer anti-estrogen resistance protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q6I2
    Conserved Domains (1) summary
    cl02485
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  6. XM_038541309.1 → XP_038397237.1  breast cancer anti-estrogen resistance protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q6I2
    Conserved Domains (1) summary
    cl02485
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006588.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    58076009..58232203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005621899.4 → XP_005621956.1  breast cancer anti-estrogen resistance protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005621956.1

    UniProtKB/TrEMBL
    A0A8C0KDA6, A0A8C0Q0J2, A0A8P0PD45, A0A8P0T468
    Conserved Domains (2) summary
    cd10337
    Location:147 → 274
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:535 → 810
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  2. XM_022420453.2 → XP_022276161.1  breast cancer anti-estrogen resistance protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KDA6, A0A8C0Q0J2, A0A8P0PD45, A0A8P0T468
    Conserved Domains (2) summary
    cd10337
    Location:147 → 274
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:535 → 810
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  3. XM_005621898.4 → XP_005621955.1  breast cancer anti-estrogen resistance protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005621955.1

    UniProtKB/TrEMBL
    A0A8C0KDA6, A0A8C0Q0J2, A0A8P0PD45, A0A8P0T468
    Conserved Domains (2) summary
    cd10337
    Location:147 → 274
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:535 → 810
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  4. XM_005621900.4 → XP_005621957.1  breast cancer anti-estrogen resistance protein 3 isoform X2

    UniProtKB/TrEMBL
    A0A8C0KGC2, A0A8C0Q1X1, A0A8C0Q4T6, A0A8I3P3I3, A0A8I3P6Y6, A0A8P0SP04
    Conserved Domains (2) summary
    cd10337
    Location:56 → 183
    SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
    cl02485
    Location:444 → 719
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  5. XM_014114822.3 → XP_013970297.1  breast cancer anti-estrogen resistance protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q6I2
    Conserved Domains (1) summary
    cl02485
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

  6. XM_038554922.1 → XP_038410850.1  breast cancer anti-estrogen resistance protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q6I2
    Conserved Domains (1) summary
    cl02485
    Location:220 → 495
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
Nucleotide Protein
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