DIS3L DIS3 like exosome 3'-5' exoribonuclease [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: DIS3Lprovided by VGNC
Official Full Name: DIS3 like exosome 3'-5' exoribonucleaseprovided by VGNC
Primary source: VGNC:VGNC:39963
See related: Ensembl:ENSCAFG00845015076
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 30

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	30	NC_051834.1 (30801013..30834821)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	30	NC_006612.4 (30538303..30572113)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	30	NC_049251.1 (31035632..31069740)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	30	NC_049290.1 (30730599..30764419)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	30	NC_049771.1 (30793879..30827679)

Chromosome 30 - NC_051834.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in rRNA catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of cytoplasmic exosome (RNase complex)	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DIS3-like exonuclease 1

Names: DIS3 mitotic control homolog-like

XP_038298626.1

EC 3.1.13.1

XP_038298627.1

EC 3.1.13.1

XP_038298628.1

EC 3.1.13.1

XP_038298629.1

EC 3.1.13.1

XP_038317382.1

EC 3.1.13.1

XP_038317383.1

EC 3.1.13.1

XP_038317384.1

EC 3.1.13.1

XP_038317385.1

EC 3.1.13.1

XP_038373064.1

EC 3.1.13.1

XP_038373065.1

EC 3.1.13.1

XP_038373066.1

EC 3.1.13.1

XP_038373067.1

EC 3.1.13.1

XP_038436691.1

EC 3.1.13.1

XP_038436692.1

EC 3.1.13.1

XP_038436693.1

EC 3.1.13.1

XP_038436694.1

EC 3.1.13.1

XP_038501009.1

EC 3.1.13.1

XP_038501010.1

EC 3.1.13.1

XP_038501011.1

EC 3.1.13.1

XP_038501012.1

EC 3.1.13.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051834.1 Reference ROS_Cfam_1.0

Range

30801013..30834821

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038442699.1 → XP_038298627.1 DIS3-like exonuclease 1 isoform X2

UniProtKB/TrEMBL

A0A8I3NLW0, A0A8P0TLQ1

Related

ENSCAFP00845021321.1, ENSCAFT00845027094.1

Conserved Domains (2) summary

COG0557
Location:207 → 916

VacB; Exoribonuclease R [Transcription]

cd09862
Location:1 → 130

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_038442700.1 → XP_038298628.1 DIS3-like exonuclease 1 isoform X3

UniProtKB/TrEMBL

A0A8C0TSM1

Conserved Domains (2) summary

cd09862
Location:11 → 188

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs

cl39058
Location:265 → 796

RNB; RNB domain
XM_038442698.1 → XP_038298626.1 DIS3-like exonuclease 1 isoform X1

UniProtKB/TrEMBL

A0A8C0K5E0, A0A8C0NDK5, A0A8C0TSM1, A0A8I3NWM4

Related

ENSCAFP00845021234.1, ENSCAFT00845026980.1

Conserved Domains (2) summary

COG0557
Location:265 → 974

VacB; Exoribonuclease R [Transcription]

cd09862
Location:11 → 188

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_038442701.1 → XP_038298629.1 DIS3-like exonuclease 1 isoform X4

Conserved Domains (1) summary

COG0557
Location:19 → 604

VacB; Exoribonuclease R [Transcription]

Alternate UMICH_Zoey_3.1

Genomic

NC_049290.1 Alternate UMICH_Zoey_3.1

Range

30730599..30764419

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038517137.1 → XP_038373065.1 DIS3-like exonuclease 1 isoform X2

Conserved Domains (2) summary

COG0557
Location:207 → 916

VacB; Exoribonuclease R [Transcription]

cd09862
Location:1 → 130

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_038517138.1 → XP_038373066.1 DIS3-like exonuclease 1 isoform X3

Conserved Domains (2) summary

cd09862
Location:11 → 188

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs

cl39058
Location:265 → 796

RNB; RNB domain
XM_038517136.1 → XP_038373064.1 DIS3-like exonuclease 1 isoform X1

Conserved Domains (2) summary

COG0557
Location:265 → 974

VacB; Exoribonuclease R [Transcription]

cd09862
Location:11 → 188

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_038517139.1 → XP_038373067.1 DIS3-like exonuclease 1 isoform X4

Conserved Domains (1) summary

COG0557
Location:19 → 604

VacB; Exoribonuclease R [Transcription]

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049771.1 Alternate UNSW_CanFamBas_1.0

Range

30793879..30827679

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038645082.1 → XP_038501010.1 DIS3-like exonuclease 1 isoform X2

Conserved Domains (2) summary

COG0557
Location:207 → 916

VacB; Exoribonuclease R [Transcription]

cd09862
Location:1 → 130

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_038645083.1 → XP_038501011.1 DIS3-like exonuclease 1 isoform X3

Conserved Domains (2) summary

cd09862
Location:11 → 188

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs

cl39058
Location:265 → 796

RNB; RNB domain
XM_038645081.1 → XP_038501009.1 DIS3-like exonuclease 1 isoform X1

Conserved Domains (2) summary

COG0557
Location:265 → 974

VacB; Exoribonuclease R [Transcription]

cd09862
Location:11 → 188

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_038645084.1 → XP_038501012.1 DIS3-like exonuclease 1 isoform X4

Conserved Domains (1) summary

COG0557
Location:19 → 604

VacB; Exoribonuclease R [Transcription]

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049251.1 Alternate UU_Cfam_GSD_1.0

Range

31035632..31069740

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038580764.1 → XP_038436692.1 DIS3-like exonuclease 1 isoform X2

UniProtKB/TrEMBL

A0A8I3NLW0, A0A8P0TLQ1

Conserved Domains (2) summary

COG0557
Location:207 → 916

VacB; Exoribonuclease R [Transcription]

cd09862
Location:1 → 130

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_038580765.1 → XP_038436693.1 DIS3-like exonuclease 1 isoform X3

UniProtKB/TrEMBL

A0A8C0TSM1

Conserved Domains (2) summary

cd09862
Location:11 → 188

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs

cl39058
Location:265 → 796

RNB; RNB domain
XM_038580763.1 → XP_038436691.1 DIS3-like exonuclease 1 isoform X1

UniProtKB/TrEMBL

A0A8C0K5E0, A0A8C0NDK5, A0A8C0TSM1, A0A8I3NWM4

Conserved Domains (2) summary

COG0557
Location:265 → 974

VacB; Exoribonuclease R [Transcription]

cd09862
Location:11 → 188

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_038580766.1 → XP_038436694.1 DIS3-like exonuclease 1 isoform X4

Conserved Domains (1) summary

COG0557
Location:19 → 604

VacB; Exoribonuclease R [Transcription]

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006612.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

30538303..30572113

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038461455.1 → XP_038317383.1 DIS3-like exonuclease 1 isoform X2

UniProtKB/TrEMBL

A0A8I3NLW0, A0A8P0TLQ1

Conserved Domains (2) summary

COG0557
Location:207 → 916

VacB; Exoribonuclease R [Transcription]

cd09862
Location:1 → 130

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_038461456.1 → XP_038317384.1 DIS3-like exonuclease 1 isoform X3

UniProtKB/TrEMBL

A0A8C0TSM1

Conserved Domains (2) summary

cd09862
Location:11 → 188

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs

cl39058
Location:265 → 796

RNB; RNB domain
XM_038461454.1 → XP_038317382.1 DIS3-like exonuclease 1 isoform X1

UniProtKB/TrEMBL

A0A8C0K5E0, A0A8C0NDK5, A0A8C0TSM1, A0A8I3NWM4

Conserved Domains (2) summary

COG0557
Location:265 → 974

VacB; Exoribonuclease R [Transcription]

cd09862
Location:11 → 188

PIN_Rrp44-like; VapC-like PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
XM_038461457.1 → XP_038317385.1 DIS3-like exonuclease 1 isoform X4

Conserved Domains (1) summary

COG0557
Location:19 → 604

VacB; Exoribonuclease R [Transcription]