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DIS3L DIS3 like exosome 3'-5' exoribonuclease [ Homo sapiens (human) ]

Gene ID: 115752, updated on 11-Jun-2021

Summary

Official Symbol
DIS3Lprovided by HGNC
Official Full Name
DIS3 like exosome 3'-5' exoribonucleaseprovided by HGNC
Primary source
HGNC:HGNC:28698
See related
Ensembl:ENSG00000166938 MIM:614183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIS3L1
Summary
The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 7.4) and 25 other tissues See more
Orthologs
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Genomic context

See DIS3L in Genome Data Viewer
Location:
15q22.31
Exon count:
21
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (66293309..66333898)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66585647..66626236)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 11 Neighboring gene uncharacterized LOC105370867 Neighboring gene microRNA 4311 Neighboring gene DIS3L antisense RNA 1 Neighboring gene small Cajal body-specific RNA 14 Neighboring gene TIMELESS interacting protein Neighboring gene ribosomal protein L9 pseudogene 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4562, FLJ38088, KIAA1955

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3'-5'-exoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3'-5'-exoribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3'-5'-exoribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, exonucleolytic IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in rRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of cytoplasmic exosome (RNase complex) IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
part_of exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
DIS3-like exonuclease 1
Names
DIS3 mitotic control homolog-like
NP_001137160.1
NP_001310865.1
NP_001310866.1
NP_001310867.1
NP_001310868.1
NP_001310869.1
NP_001310870.1
NP_001310872.1
NP_001310873.1
NP_001310874.1
NP_001310875.1
NP_001310877.1
NP_588616.1
XP_005254203.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050688.1 RefSeqGene

    Range
    5054..45643
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001143688.3NP_001137160.1  DIS3-like exonuclease 1 isoform 1

    See identical proteins and their annotated locations for NP_001137160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC055855
    Consensus CDS
    CCDS45286.1
    UniProtKB/Swiss-Prot
    Q8TF46
    Related
    ENSP00000321711.4, ENST00000319212.9
    Conserved Domains (3) summary
    COG0557
    Location:265955
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:465815
    RNB; RNB domain
    cl14812
    Location:12188
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  2. NM_001323936.2NP_001310865.1  DIS3-like exonuclease 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Consensus CDS
    CCDS10214.1
    UniProtKB/Swiss-Prot
    Q8TF46
    Conserved Domains (2) summary
    COG0557
    Location:182872
    VacB; Exoribonuclease R [Transcription]
    cl14812
    Location:2105
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  3. NM_001323937.2NP_001310866.1  DIS3-like exonuclease 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Conserved Domains (2) summary
    COG0557
    Location:139829
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:339689
    RNB; RNB domain
  4. NM_001323938.2NP_001310867.1  DIS3-like exonuclease 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC055855
    UniProtKB/Swiss-Prot
    Q8TF46
    Conserved Domains (2) summary
    COG0557
    Location:131821
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:331681
    RNB; RNB domain
  5. NM_001323939.2NP_001310868.1  DIS3-like exonuclease 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC055855
    UniProtKB/Swiss-Prot
    Q8TF46
    Conserved Domains (2) summary
    COG0557
    Location:131821
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:331681
    RNB; RNB domain
  6. NM_001323940.2NP_001310869.1  DIS3-like exonuclease 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC055855
  7. NM_001323941.2NP_001310870.1  DIS3-like exonuclease 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC055855
    UniProtKB/Swiss-Prot
    Q8TF46
    Conserved Domains (2) summary
    COG0557
    Location:131821
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:331681
    RNB; RNB domain
  8. NM_001323943.2NP_001310872.1  DIS3-like exonuclease 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC055855
  9. NM_001323944.2NP_001310873.1  DIS3-like exonuclease 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Conserved Domains (3) summary
    COG0557
    Location:248938
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:448798
    RNB; RNB domain
    cl14812
    Location:14171
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  10. NM_001323945.2NP_001310874.1  DIS3-like exonuclease 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Consensus CDS
    CCDS10214.1
    UniProtKB/Swiss-Prot
    Q8TF46
    Conserved Domains (2) summary
    COG0557
    Location:182872
    VacB; Exoribonuclease R [Transcription]
    cl14812
    Location:2105
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
  11. NM_001323946.2NP_001310875.1  DIS3-like exonuclease 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC055855
    UniProtKB/Swiss-Prot
    Q8TF46
    Conserved Domains (2) summary
    COG0557
    Location:131821
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:331681
    RNB; RNB domain
  12. NM_001323948.2NP_001310877.1  DIS3-like exonuclease 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC055855
  13. NM_133375.5NP_588616.1  DIS3-like exonuclease 1 isoform 2

    See identical proteins and their annotated locations for NP_588616.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents an alternate first exon and the transcript has a smaller open reading frame compared to variant 1. The resulting protein isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC055855
    Consensus CDS
    CCDS10214.1
    UniProtKB/Swiss-Prot
    Q8TF46
    Related
    ENSP00000321583.5, ENST00000319194.9
    Conserved Domains (2) summary
    COG0557
    Location:182872
    VacB; Exoribonuclease R [Transcription]
    cl14812
    Location:2105
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    66293309..66333898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254146.4XP_005254203.1  DIS3-like exonuclease 1 isoform X1

    Conserved Domains (3) summary
    COG0557
    Location:265843
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:465815
    RNB; RNB domain
    cl14812
    Location:12188
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
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