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ADARB1 adenosine deaminase RNA specific B1 [ Pan troglodytes (chimpanzee) ]

Gene ID: 474045, updated on 3-Apr-2024

Summary

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Gene symbol
ADARB1
Gene description
adenosine deaminase RNA specific B1
Locus tag
CK820_G0022998
See related
Ensembl:ENSPTRG00000013997
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Pan troglodytes
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs
human mouse all
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Genomic context

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See ADARB1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 22 NC_072420.2 (45723056..45880007)
RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 21 NC_072419.1 (43375827..43532759)

Chromosome 22 - NC_072420.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein encoded by LINC01547 Neighboring gene SLX9 ribosome biogenesis factor Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC112206637

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables double-stranded RNA adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tRNA-specific adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adenosine to inosine editing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
double-stranded RNA-specific editase 1
Names
RNA-specific adenosine deaminase B1
adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)
NP_001122104.2
NP_001155265.1
NP_001155266.1
NP_001155267.1
XP_024208098.1
XP_024208100.1
XP_024208102.1
XP_054531019.1
XP_054531024.1
XP_054531025.1
XP_063659419.1
XP_063659420.1
XP_063659421.1
XP_063659422.1
XP_063659423.1
XP_063659424.1
XP_063659425.1
XP_063659426.1
XP_063659427.1
XP_063659428.1
XP_063659429.1
XP_063659430.1
XP_063659431.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128632.3 → NP_001122104.2  double-stranded RNA-specific editase 1 isoform 1

    See identical proteins and their annotated locations for NP_001122104.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks the ALU cassette insert and contains the long C-terminal region, as compared to variant 2. The resulting isoform (1) lacks an internal segment, compared to isoform 2.
    Source sequence(s)
    AL954256, GABD01004812, GABE01027696, GABE01028313
    UniProtKB/TrEMBL
    A0A2J8M8P7, A0A6D2VUT5, H2QZM5
    Related
    ENSPTRP00000039204.3, ENSPTRT00000047975.4
    Conserved Domains (3) summary
    cd19895
    Location:75 → 146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232 → 301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    pfam02137
    Location:370 → 691
    A_deamin; Adenosine-deaminase (editase) domain

  2. NM_001161793.2 → NP_001155265.1  double-stranded RNA-specific editase 1 isoform 3

    See identical proteins and their annotated locations for NP_001155265.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate segment in the 3' coding region, compared to variant 2. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 2, and contains the ALU cassette insert and the short C-terminal region.
    Source sequence(s)
    GABC01018536, GABC01018537, GABD01017016, GABE01028313
    UniProtKB/TrEMBL
    A0A2J8M8R1
    Related
    ENSPTRP00000024094.4, ENSPTRT00000026120.5
    Conserved Domains (3) summary
    cd19895
    Location:75 → 146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232 → 301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    pfam02137
    Location:370 → 712
    A_deamin; Adenosine-deaminase (editase) domain

  3. NM_001161794.2 → NP_001155266.1  double-stranded RNA-specific editase 1 isoform 2

    See identical proteins and their annotated locations for NP_001155266.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript, which includes the ALU cassette insert and the long C-terminal region. It encodes the longest isoform (2).
    Source sequence(s)
    AL954256, GABC01018536, GABC01018537, GABD01017016, GABE01027696, GABE01028313
    UniProtKB/TrEMBL
    A0A2J8M8R2, A0A6D2W2Q8, H2QL56
    Conserved Domains (3) summary
    smart00552
    Location:322 → 738
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:75 → 146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232 → 301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

  4. NM_001161795.2 → NP_001155267.1  double-stranded RNA-specific editase 1 isoform 4

    See identical proteins and their annotated locations for NP_001155267.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks the ALU cassette insert and an alternate segment in the 3' coding region, compared to variant 2. The resulting isoform (4) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 2, and contains the short C-terminal region.
    Source sequence(s)
    GABD01017016, GABE01028313
    Related
    ENSPTRP00000085581.1, ENSPTRT00000094595.1
    Conserved Domains (3) summary
    cd19895
    Location:75 → 146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232 → 301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    pfam02137
    Location:370 → 672
    A_deamin; Adenosine-deaminase (editase) domain

RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

  1. NC_072420.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Range
    45723056..45880007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063803361.1 → XP_063659431.1  double-stranded RNA-specific editase 1 isoform X10

    UniProtKB/TrEMBL
    A0A2I3T8K9, A0A2J8M8Q9, A0A6D2Y478

  2. XM_063803354.1 → XP_063659424.1  double-stranded RNA-specific editase 1 isoform X1

  3. XM_063803356.1 → XP_063659426.1  double-stranded RNA-specific editase 1 isoform X3

  4. XM_063803358.1 → XP_063659428.1  double-stranded RNA-specific editase 1 isoform X5

  5. XM_024352330.3 → XP_024208098.1  double-stranded RNA-specific editase 1 isoform X7

    Conserved Domains (2) summary
    smart00552
    Location:380 → 726
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd00048
    Location:137 → 200
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

  6. XM_063803357.1 → XP_063659427.1  double-stranded RNA-specific editase 1 isoform X4

  7. XM_063803350.1 → XP_063659420.1  double-stranded RNA-specific editase 1 isoform X1

  8. XM_063803349.1 → XP_063659419.1  double-stranded RNA-specific editase 1 isoform X1

  9. XM_054675044.2 → XP_054531019.1  double-stranded RNA-specific editase 1 isoform X8

    UniProtKB/TrEMBL
    A0A2J8M8R2, A0A6D2W2Q8, H2QL56

  10. XM_054675049.2 → XP_054531024.1  double-stranded RNA-specific editase 1 isoform X8

    UniProtKB/TrEMBL
    A0A2J8M8R2, A0A6D2W2Q8, H2QL56

  11. XM_063803351.1 → XP_063659421.1  double-stranded RNA-specific editase 1 isoform X1

  12. XM_063803352.1 → XP_063659422.1  double-stranded RNA-specific editase 1 isoform X1

  13. XM_063803353.1 → XP_063659423.1  double-stranded RNA-specific editase 1 isoform X1

  14. XM_024352334.3 → XP_024208102.1  double-stranded RNA-specific editase 1 isoform X8

    UniProtKB/TrEMBL
    A0A2J8M8R2, A0A6D2W2Q8, H2QL56
    Conserved Domains (3) summary
    smart00552
    Location:322 → 738
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:75 → 146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232 → 301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

  15. XM_024352332.3 → XP_024208100.1  double-stranded RNA-specific editase 1 isoform X8

    UniProtKB/TrEMBL
    A0A2J8M8R2, A0A6D2W2Q8, H2QL56
    Conserved Domains (3) summary
    smart00552
    Location:322 → 738
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:75 → 146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232 → 301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

  16. XM_063803360.1 → XP_063659430.1  double-stranded RNA-specific editase 1 isoform X9

  17. XM_063803355.1 → XP_063659425.1  double-stranded RNA-specific editase 1 isoform X2

  18. XM_063803359.1 → XP_063659429.1  double-stranded RNA-specific editase 1 isoform X9

  19. XM_054675050.2 → XP_054531025.1  double-stranded RNA-specific editase 1 isoform X6

Nucleotide Protein
Heading Accession and Version

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