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Adarb1 adenosine deaminase, RNA-specific, B1 [ Mus musculus (house mouse) ]

Gene ID: 110532, updated on 17-Aug-2021

Summary

Official Symbol
Adarb1provided by MGI
Official Full Name
adenosine deaminase, RNA-specific, B1provided by MGI
Primary source
MGI:MGI:891999
See related
Ensembl:ENSMUSG00000020262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AD; RED; Red1; Adar2; AW124433; AW558573; BB220382; D10Bwg0447e; 1700057H01Rik
Summary
This gene encodes a double-stranded-RNA-specific adenosine deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in cerebellum adult (RPKM 24.4), frontal lobe adult (RPKM 19.8) and 18 other tissues See more
Orthologs
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Genomic context

See Adarb1 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77126561..77254125, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77290727..77418292, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (76753472..76881018, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40703 Neighboring gene predicted gene 10941 Neighboring gene protein O-fucosyltransferase 2 Neighboring gene predicted gene, 17769 Neighboring gene predicted gene, 51791

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded RNA adenosine deaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA adenosine deaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in RNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in RNA processing ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in adenosine to inosine editing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adenosine to inosine editing IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within adenosine to inosine editing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenosine to inosine editing ISO
Inferred from Sequence Orthology
more info
 
involved_in base conversion or substitution editing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within facial nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hypoglossal nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA modification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within motor behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within motor neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuromuscular process controlling posture IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mRNA processing ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spinal cord ventral commissure morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
double-stranded RNA-specific editase 1
Names
RNA-editing deaminase 1
RNA-editing enzyme 1
dsRNA adenosine deaminase
NP_001020008.1
NP_001020009.1
NP_570965.2
XP_006513125.1
XP_006513126.1
XP_006513127.1
XP_030100683.1
XP_036011393.1
XP_036011394.1
XP_036011395.1
XP_036011396.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024837.2NP_001020008.1  double-stranded RNA-specific editase 1 isoform 2

    See identical proteins and their annotated locations for NP_001020008.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame donor splice site at one of the internal coding exons, compared to transcript variant 1. This results in a longer isoform (2) containing a 10 aa segment that is missing in isoform 1.
    Source sequence(s)
    AF403107, BB622419, BC030049, BC040200
    Consensus CDS
    CCDS35948.1
    UniProtKB/Swiss-Prot
    Q91ZS8
    Related
    ENSMUSP00000095976.3, ENSMUST00000098374.9
    Conserved Domains (3) summary
    smart00552
    Location:322708
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:75146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
  2. NM_001024838.2NP_001020009.1  double-stranded RNA-specific editase 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AK141777, AK164931, BC030049, BC040200, BY281644
    Conserved Domains (3) summary
    smart00552
    Location:316692
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:69140
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:226295
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
  3. NM_130895.3NP_570965.2  double-stranded RNA-specific editase 1 isoform 1

    See identical proteins and their annotated locations for NP_570965.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1).
    Source sequence(s)
    AF291049, AF403107, BB622419, BC030049, BC040200
    Consensus CDS
    CCDS35949.1
    UniProtKB/Swiss-Prot
    Q91ZS8
    Related
    ENSMUSP00000020496.8, ENSMUST00000020496.14
    Conserved Domains (3) summary
    smart00552
    Location:322698
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:75146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

RNA

  1. NR_004429.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate, in-frame donor splice site at one of the internal coding exons, and results from an auto RNA editing event (AA->AI) that creates a novel acceptor splice site, splicing to which inserts 47 nt into the coding region, compared to transcript variant 1. This causes a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). According to PMIDs:12459255 and 16382140, the RNA editing_induced_alternative splicing is observed at a frequency of 80% in mouse and serves to regulate Adarb1 protein expression and activity in vivo.
    Source sequence(s)
    AF403109, BB622419, BC030049, BC040200
    Related
    ENSMUST00000144547.8
  2. NR_021486.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) results from an auto RNA editing event (AA->AI) that creates a novel acceptor splice site, splicing to which inserts 47 nt into the coding region, compared to transcript variant 1. This causes a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD). According to PMIDs:12459255 and 16382140, the RNA editing_induced_alternative splicing is observed at a frequency of 80% in mouse and serves to regulate Adarb1 protein expression and activity in vivo.
    Source sequence(s)
    AF403108, BC030049, BC040200, CJ115965
    Related
    ENSMUST00000105404.9

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    77126561..77254125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513064.3XP_006513127.1  double-stranded RNA-specific editase 1 isoform X4

    Conserved Domains (3) summary
    smart00552
    Location:316702
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:69140
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:226295
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
  2. XM_036155500.1XP_036011393.1  double-stranded RNA-specific editase 1 isoform X3

    Conserved Domains (3) summary
    smart00552
    Location:322708
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:75146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
  3. XM_036155501.1XP_036011394.1  double-stranded RNA-specific editase 1 isoform X3

    Conserved Domains (3) summary
    smart00552
    Location:322708
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:75146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
  4. XM_030244823.2XP_030100683.1  double-stranded RNA-specific editase 1 isoform X3

    Conserved Domains (3) summary
    smart00552
    Location:322708
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:75146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
  5. XM_006513063.4XP_006513126.1  double-stranded RNA-specific editase 1 isoform X2

    Conserved Domains (3) summary
    smart00552
    Location:386762
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:139210
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:296365
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
  6. XM_006513062.4XP_006513125.1  double-stranded RNA-specific editase 1 isoform X1

    Conserved Domains (3) summary
    smart00552
    Location:386772
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:139210
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:296365
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
  7. XM_036155503.1XP_036011396.1  double-stranded RNA-specific editase 1 isoform X4

    Conserved Domains (3) summary
    smart00552
    Location:316702
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:69140
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:226295
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
  8. XM_036155502.1XP_036011395.1  double-stranded RNA-specific editase 1 isoform X3

    Conserved Domains (3) summary
    smart00552
    Location:322708
    ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    cd19895
    Location:75146
    DSRM_RED1_rpt1; first double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins
    cd19898
    Location:232301
    DSRM_RED1_rpt2; second double-stranded RNA binding motif of RNA-editing deaminase 1 (RED1) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024839.1: Suppressed sequence

    Description
    NM_001024839.1: This RefSeq, based on a downstream AUG, was permanently suppressed because use of the in-frame upstream AUG, with a strong Kozak signal, would render the transcript susceptible to nonsense-mediated decay.
  2. NM_001024840.1: Suppressed sequence

    Description
    NM_001024840.1: This RefSeq, based on a downstream AUG, was permanently suppressed because use of the in-frame upstream AUG, with a strong Kozak signal, would render the transcript susceptible to nonsense-mediated decay.
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