CHN2 chimerin 2 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: CHN2provided by VGNC
Official Full Name: chimerin 2provided by VGNC
Primary source: VGNC:VGNC:50368
Locus tag: CK820_G0034574
See related: Ensembl:ENSPTRG00000019030
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	6	NC_072404.2 (34996461..35314196)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	7	NC_072405.1 (32792135..33109452)

Chromosome 6 - NC_072404.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

GDB:1317316 (e-PCR)
- UniSTS:78351

D7S2007 (e-PCR)
- UniSTS:61981

RH18025 (e-PCR)
- UniSTS:72234

RH70289 (e-PCR)
- UniSTS:53034

A006G33 (e-PCR)
- UniSTS:43053

D7S1806 (e-PCR), detects polymorphism
- UniSTS:65595

SHGC-86315 (e-PCR)
- UniSTS:104518

RH12474 (e-PCR)
- UniSTS:57686

D7S2148E (e-PCR)
- UniSTS:151143

GDB:1317330 (e-PCR)
- UniSTS:3437

G42164 (e-PCR)
- UniSTS:93293

SHGC-78749 (e-PCR)
- UniSTS:95603

G69451 (e-PCR)
- UniSTS:229517

D7S617 (e-PCR)
- UniSTS:54673

D7S435 (e-PCR), detects polymorphism
- UniSTS:76188

D7S1981 (e-PCR)
- UniSTS:11423

D7S1869 (e-PCR)
- UniSTS:45999

D7S1406 (e-PCR)
- UniSTS:41401

D7S2403 (e-PCR)
- UniSTS:22458

D7S617 (e-PCR)
- UniSTS:80842

G32348 (e-PCR)
- UniSTS:116939

SHGC-58598 (e-PCR)
- UniSTS:94417

SHGC-83344 (e-PCR)
- UniSTS:95990

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: beta-chimaerin

Names: chimerin (chimaerin) 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

34996461..35314196

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016957223.4 → XP_016812712.1 beta-chimaerin isoform X1

UniProtKB/TrEMBL

A0A2I3SWD9

Conserved Domains (3) summary

cd10352
Location:65 → 151

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:288 → 481

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:223 → 283

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
XM_003318375.6 → XP_003318423.1 beta-chimaerin isoform X3

See identical proteins and their annotated locations for XP_003318423.1

UniProtKB/TrEMBL

A0A2I3SWD9, A0A2J8KZ13, A0A6D2XRP4, H2R2E9

Related

ENSPTRP00000043836.3

Conserved Domains (3) summary

cd10352
Location:52 → 138

SH2_a2chimerin_b2chimerin; Src homology 2 (SH2) domain found in alpha2-chimerin and beta2-chimerin proteins

cd04372
Location:275 → 468

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:210 → 270

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
XM_009452832.4 → XP_009451107.1 beta-chimaerin isoform X2

See identical proteins and their annotated locations for XP_009451107.1

UniProtKB/TrEMBL

A0A2I3SKD8

Conserved Domains (2) summary

cd04372
Location:129 → 322

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:64 → 124

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
XM_063814149.1 → XP_063670219.1 beta-chimaerin isoform X2

UniProtKB/TrEMBL

A0A2I3SKD8
XM_016957224.4 → XP_016812713.1 beta-chimaerin isoform X2

UniProtKB/TrEMBL

A0A2I3SKD8

Conserved Domains (2) summary

cd04372
Location:129 → 322

RhoGAP_chimaerin; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms ...

cd20857
Location:64 → 124

C1_betaCHN; protein kinase C conserved region 1 (C1 domain) found in beta-chimaerin and similar proteins
XM_063814148.1 → XP_063670218.1 beta-chimaerin isoform X2

UniProtKB/TrEMBL

A0A2I3SKD8
XM_016957226.4 → XP_016812715.1 beta-chimaerin isoform X5

UniProtKB/TrEMBL

A0A2I3SKD8
XM_063814150.1 → XP_063670220.1 beta-chimaerin isoform X4

UniProtKB/TrEMBL

A0A2I3SKD8