HECTD2 HECT domain E3 ubiquitin protein ligase 2 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: HECTD2provided by VGNC
Official Full Name: HECT domain E3 ubiquitin protein ligase 2provided by VGNC
Primary source: VGNC:VGNC:9745
Locus tag: CK820_G0004324
See related: Ensembl:ENSPTRG00000002747
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	8	NC_072406.2 (103651226..103756667)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	10	NC_072408.1 (94269179..94377508)

Chromosome 8 - NC_072406.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH46925 (e-PCR)
- UniSTS:30471

stSG70363 (e-PCR)
- UniSTS:181805

D10S1396E (e-PCR)
- UniSTS:151394

SHGC-82330 (e-PCR)
- UniSTS:104298

SHGC-105708 (e-PCR)
- UniSTS:169410

RH66237 (e-PCR)
- UniSTS:92877

RH44740 (e-PCR)
- UniSTS:35035

SHGC-84908 (e-PCR)
- UniSTS:104942

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: probable E3 ubiquitin-protein ligase HECTD2

Names: HECT domain containing 2; HECT domain containing E3 ubiquitin protein ligase 2

XP_016774332.1

EC 2.3.2.26

EC 6.3.2.-

XP_016774333.1

EC 2.3.2.26

EC 6.3.2.-

XP_016774334.1

EC 2.3.2.26

EC 6.3.2.-

XP_016774335.1

EC 2.3.2.26

EC 6.3.2.-

XP_063638040.1

EC 2.3.2.26

EC 6.3.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072406.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

103651226..103756667

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063781970.1 → XP_063638040.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X5

UniProtKB/TrEMBL

A0A2I3RAM0, A0A2J8PE93, A0A6D2XVF5
XM_016918846.4 → XP_016774335.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X4

UniProtKB/TrEMBL

A0A2I3RAM0, A0A2J8PE93, A0A6D2XVF5

Conserved Domains (2) summary

smart00119
Location:338 → 671

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:315 → 672

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_016918844.4 → XP_016774333.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X1

UniProtKB/TrEMBL

A0A2I3RAM0, A0A2J8PE93, A0A2J8PE94, A0A6D2W5Z4, A0A6D2XVF5, H2R7K9, K7DC50

Related

ENSPTRP00000050526.4

Conserved Domains (1) summary

cd00078
Location:417 → 774

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
XM_016918843.4 → XP_016774332.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X3

UniProtKB/TrEMBL

A0A2I3RAM0, A0A2J8PE93, A0A6D2XVF5
XM_016918845.4 → XP_016774334.1 probable E3 ubiquitin-protein ligase HECTD2 isoform X2

UniProtKB/TrEMBL

A0A2I3RAM0, A0A2J8PE93, A0A6D2XVF5