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HECTD2 HECT domain E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 143279, updated on 12-Aug-2022

Summary

Official Symbol
HECTD2provided by HGNC
Official Full Name
HECT domain E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:HGNC:26736
See related
Ensembl:ENSG00000165338 AllianceGenome:HGNC:26736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 5.7), brain (RPKM 4.5) and 24 other tissues See more
Orthologs
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Genomic context

See HECTD2 in Genome Data Viewer
Location:
10q23.32
Exon count:
26
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (91409235..91514820)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (92292590..92398174)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93168992..93274577)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902480 Neighboring gene polycomb group ring finger 5 Neighboring gene Sharpr-MPRA regulatory region 216 Neighboring gene HECTD2 antisense RNA 1 Neighboring gene uncharacterized LOC105378433 Neighboring gene ribosomal protein S27 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16050

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase HECTD2
Names
HECT domain containing E3 ubiquitin protein ligase 2
HECT domain-containing protein 2
HECT-type E3 ubiquitin transferase HECTD2
NP_001271203.2
NP_001335294.1
NP_775768.4
NP_877497.4
XP_024303596.1
XP_047280612.1
XP_047280613.1
XP_047280614.1
XP_047280615.1
XP_047280616.1
XP_047280617.1
XP_047280618.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284274.3NP_001271203.2  probable E3 ubiquitin-protein ligase HECTD2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
    Source sequence(s)
    AC023902, AL161798
    Consensus CDS
    CCDS60591.1
    UniProtKB/TrEMBL
    E7ERR3
    Related
    ENSP00000401023.1, ENST00000446394.5
    Conserved Domains (1) summary
    cd00078
    Location:421778
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  2. NM_001348365.2NP_001335294.1  probable E3 ubiquitin-protein ligase HECTD2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' terminal exon and lacks an alternate in-frame exon in the 5' coding region compared to variant 3. These differences result in the use of a downstream start codon compared to variant 3. The encoded isoform (d) has a shorter N-terminus compared to isoform c
    Source sequence(s)
    AC023902, AL161798, BC036487
    Conserved Domains (1) summary
    cd00078
    Location:310667
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  3. NM_173497.4NP_775768.4  probable E3 ubiquitin-protein ligase HECTD2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 3. The resulting isoform (b) has a distinct C-terminus and is shorter than isoform c.
    Source sequence(s)
    AC023902, AL161798
    Consensus CDS
    CCDS7415.1
    Related
    ENSP00000360746.4, ENST00000371681.8
  4. NM_182765.6NP_877497.4  probable E3 ubiquitin-protein ligase HECTD2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 5' coding region compared to variant 3. It encodes isoform a which is shorter compared to isoform c.
    Source sequence(s)
    AC023902, AL161798
    Consensus CDS
    CCDS7414.1
    UniProtKB/Swiss-Prot
    Q8TCP5
    Related
    ENSP00000298068.5, ENST00000298068.10
    Conserved Domains (1) summary
    cd00078
    Location:417774
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RNA

  1. NR_104291.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple difference compared to variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC023902, AL161798
  2. NR_145526.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an alternate internal exon and uses alternate splice sites in two internal exon compared to variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC023902, AL161798

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    91409235..91514820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424658.1XP_047280614.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

  2. XM_047424659.1XP_047280615.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

  3. XM_047424660.1XP_047280616.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

  4. XM_047424656.1XP_047280612.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X1

  5. XM_047424661.1XP_047280617.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X4

  6. XM_047424662.1XP_047280618.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X5

  7. XM_024447828.2XP_024303596.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

    Conserved Domains (1) summary
    cd00078
    Location:310667
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  8. XM_047424657.1XP_047280613.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    92292590..92398174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)