IQGAP2 IQ motif containing GTPase activating protein 2 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: IQGAP2provided by VGNC
Official Full Name: IQ motif containing GTPase activating protein 2provided by VGNC
Primary source: VGNC:VGNC:4048
Locus tag: CK820_G0009410
See related: Ensembl:ENSPTRG00000017002
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 40

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	4	NC_072402.2 (39335663..39639824, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	5	NC_072403.1 (39753376..40058338, complement)

Chromosome 4 - NC_072402.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

WI-11362 (e-PCR)
- UniSTS:76035

G63437 (e-PCR)
- UniSTS:140549

SHGC-144593 (e-PCR)
- UniSTS:172300

RH120796 (e-PCR)
- UniSTS:132877

RH45967 (e-PCR)
- UniSTS:85781

SHGC-148469 (e-PCR)
- UniSTS:176410

D5S1678E (e-PCR)
- UniSTS:151067

RH92644 (e-PCR)
- UniSTS:86567

RH119622 (e-PCR)
- UniSTS:133940

MARC_17727-17728:1031758304:1 (e-PCR)
- UniSTS:268387

IQGAP2__6472 (e-PCR)
- UniSTS:463998

RH70668 (e-PCR)
- UniSTS:82051

SHGC-104986 (e-PCR)
- UniSTS:169094

D5S2432 (e-PCR)
- UniSTS:78227

SHGC-57970 (e-PCR)
- UniSTS:1202

SHGC-83998 (e-PCR)
- UniSTS:104628

Iqgap2 (e-PCR), detects polymorphism
- UniSTS:256441

STS-N26732 (e-PCR)
- UniSTS:64186

SHGC-144459 (e-PCR)
- UniSTS:172254

SHGC-143662 (e-PCR)
- UniSTS:172005

F2RL2_622 (e-PCR)
- UniSTS:277222

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in mitotic actomyosin contractile ring assembly actin filament organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ras GTPase-activating-like protein IQGAP2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072402.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

39335663..39639824 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001146396.6 → XP_001146396.1 ras GTPase-activating-like protein IQGAP2 isoform X1

UniProtKB/TrEMBL

A0A2I3TWS1, A0A2J8NNB7, A0A2J8NNB8, A0A6D2Y3R1

Related

ENSPTRP00000093432.1

Conserved Domains (3) summary

smart00015
Location:689 → 710

IQ; Calmodulin-binding motif

cl02569
Location:916 → 1274

RasGAP; Ras GTPase Activating Domain

cl27227
Location:784 → 1575

RasGAP_C; RasGAP C-terminus
XM_009448991.4 → XP_009447266.1 ras GTPase-activating-like protein IQGAP2 isoform X4

UniProtKB/TrEMBL

A0A2J8NNB8

Conserved Domains (4) summary

smart00323
Location:848 → 1177

RasGAP; GTPase-activator protein for Ras-like GTPases

cd00014
Location:42 → 156

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

pfam03836
Location:1310 → 1441

RasGAP_C; RasGAP C-terminus

cl02569
Location:859 → 1217

RasGAP; Ras GTPase Activating Domain
XM_063811148.1 → XP_063667218.1 ras GTPase-activating-like protein IQGAP2 isoform X2

UniProtKB/TrEMBL

A0A2I3RND5
XM_063811150.1 → XP_063667220.1 ras GTPase-activating-like protein IQGAP2 isoform X5

UniProtKB/TrEMBL

A0A2I3RND5
XM_063811147.1 → XP_063667217.1 ras GTPase-activating-like protein IQGAP2 isoform X2

UniProtKB/TrEMBL

A0A2I3RND5
XM_063811151.1 → XP_063667221.1 ras GTPase-activating-like protein IQGAP2 isoform X6

UniProtKB/TrEMBL

A0A2I3RND5
XM_063811149.1 → XP_063667219.1 ras GTPase-activating-like protein IQGAP2 isoform X3

UniProtKB/TrEMBL

A0A2I3RND5, A0A2J8NNE7, A0A6D2XEZ4, H2R5M9
XM_016953119.3 → XP_016808608.1 ras GTPase-activating-like protein IQGAP2 isoform X7

UniProtKB/TrEMBL

A0A2I3RKZ3, A0A2J8NNB9, A0A2J8NNC8, A0A6D2W8Z8

Related

ENSPTRP00000065347.1

Conserved Domains (2) summary

cd05131
Location:412 → 770

RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2

cl27227
Location:280 → 1071

RasGAP_C; RasGAP C-terminus