U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Iqgap2 IQ motif containing GTPase activating protein 2 [ Mus musculus (house mouse) ]

Gene ID: 544963, updated on 8-Feb-2024

Summary

Official Symbol
Iqgap2provided by MGI
Official Full Name
IQ motif containing GTPase activating protein 2provided by MGI
Primary source
MGI:MGI:2449975
See related
Ensembl:ENSMUSG00000021676 AllianceGenome:MGI:2449975
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A630053O10; 4933417J23Rik
Summary
Predicted to enable several functions, including Arp2/3 complex binding activity; GTPase activator activity; and calmodulin binding activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation; regulation of actin cytoskeleton reorganization; and thrombin-activated receptor signaling pathway. Located in microvillus. Is expressed in several structures, including alimentary system; axial skeleton; central nervous system; genitourinary system; and liver. Used to study hepatocellular carcinoma. Orthologous to human IQGAP2 (IQ motif containing GTPase activating protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in placenta adult (RPKM 18.9), liver E18 (RPKM 15.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Iqgap2 in Genome Data Viewer
Location:
13 D1; 13 50.26 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (95763685..96028788, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (95627177..95892280, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32640 Neighboring gene STARR-seq mESC enhancer starr_35328 Neighboring gene coagulation factor II thrombin receptor Neighboring gene predicted gene, 33074 Neighboring gene predicted gene, 48745 Neighboring gene predicted gene, 52062 Neighboring gene STARR-seq mESC enhancer starr_35329 Neighboring gene coagulation factor II thrombin receptor like 2 Neighboring gene predicted gene, 32702 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:96662105-96662214 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:96662521-96662711 Neighboring gene predicted gene, 24032 Neighboring gene STARR-positive B cell enhancer mm9_chr13:96730579-96730880 Neighboring gene synaptic vesicle glycoprotein 2c Neighboring gene predicted gene, 57605

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Arp2/3 complex binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ras GTPase-activating-like protein IQGAP2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_027711.1NP_081987.1  ras GTPase-activating-like protein IQGAP2

    See identical proteins and their annotated locations for NP_081987.1

    Status: VALIDATED

    Source sequence(s)
    AK142813, AK147360, CJ201339
    Consensus CDS
    CCDS36753.1
    UniProtKB/Swiss-Prot
    Q3UQ44
    UniProtKB/TrEMBL
    B9EKK3
    Related
    ENSMUSP00000067685.7, ENSMUST00000068603.8
    Conserved Domains (5) summary
    smart00015
    Location:689710
    IQ; Calmodulin-binding motif
    cd05131
    Location:9161274
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    smart00323
    Location:9051257
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd00014
    Location:42156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam03836
    Location:13671498
    RasGAP_C; RasGAP C-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    95763685..96028788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158092.1XP_036013985.1  ras GTPase-activating-like protein IQGAP2 isoform X2

    UniProtKB/TrEMBL
    B9EKK3
    Conserved Domains (4) summary
    smart00015
    Location:726747
    IQ; Calmodulin-binding motif
    cd05131
    Location:9531311
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    COG5261
    Location:8211606
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
    cl00030
    Location:53203
    CH_SF; calponin homology (CH) domain superfamily
  2. XM_036158091.1XP_036013984.1  ras GTPase-activating-like protein IQGAP2 isoform X1

    UniProtKB/TrEMBL
    B9EKK3
    Conserved Domains (4) summary
    smart00015
    Location:726747
    IQ; Calmodulin-binding motif
    cd05131
    Location:9531311
    RasGAP_IQGAP2; Ras-GTPase Activating Domain of IQ motif containing GTPase activating protein 2
    COG5261
    Location:8211612
    IQG1; Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms]
    cl00030
    Location:53203
    CH_SF; calponin homology (CH) domain superfamily