EDNRA endothelin receptor type A [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: EDNRAprovided by VGNC
Official Full Name: endothelin receptor type Aprovided by VGNC
Primary source: VGNC:VGNC:40202
See related: Ensembl:ENSCAFG00845013340
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	15	NC_051819.1 (46496528..46553179)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	15	NC_006597.4 (46219878..46270714)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	15	NC_049236.1 (46175034..46225816)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	15	NC_049275.1 (45768959..45819737)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	15	NC_049756.1 (45864678..45915481)

Chromosome 15 - NC_051819.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There was a progressive increase in ET-1 and ETAR expression from benign tumour to grade 1 and grade 2 malignant mammary tumours with a decrease of expression in grade 3 carcinomas. Co-localization of ET-1 and ETAR was observed in benign mammary tumours.
Title: Expression of endothelin-1 and endothelin-1 receptor A in canine mammary tumours.
These results showed that endothelin-1 and endothelin receptor A are overexpressed in canine ovarian tumours, suggesting a potential role of these two molecules in canine ovarian carcinogenesis.
Title: Expression of endothelin-1 and endothelin receptor a in canine ovarian tumours.
Data indicate that reduced cardiac contractile and pulmonary vasoconstrictor responses via the ETB receptor are attenuated and that responses mediated by the ETA receptor are more prominent in the context of heart failure.
Title: The functional shift of endothelin receptor subtypes in dogs with heart failure produced by rapid ventricular pacing.
Localization of expression in the testis of dogs, rats, and monkeys.
Title: Localization of endothelin receptor subtype-A in the testis of rats, dogs, and monkeys.

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General gene information

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Markers

SHGC-59477 (e-PCR)
- UniSTS:25684

D15Cor1 (e-PCR)
- UniSTS:477364

D15Cor2 (e-PCR)
- UniSTS:477365

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables endothelin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in enteric nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: endothelin-1 receptor

Names: ET-A; ET-AR; endothelin A receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031632.1 → NP_001026802.1 endothelin-1 receptor precursor

See identical proteins and their annotated locations for NP_001026802.1

Status: PROVISIONAL

Source sequence(s)

AB183284

UniProtKB/Swiss-Prot

Q5KSU9

UniProtKB/TrEMBL

A0A8P0SCZ1

Conserved Domains (1) summary

pfam00001
Location:96 → 366

7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051819.1 Reference ROS_Cfam_1.0

Range

46496528..46553179

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038687177.1 → XP_038543105.1 endothelin-1 receptor isoform X1

UniProtKB/TrEMBL

A0A8C0LKQ4, A0A8C0RZ69, A0A8P0SCZ1, F1Q0N4, Q5J7U3

Related

ENSCAFP00845018663.1, ENSCAFT00845023778.1

Conserved Domains (1) summary

cd15975
Location:80 → 379

7tmA_ET-AR; endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors