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Ednra endothelin receptor type A [ Mus musculus (house mouse) ]

Gene ID: 13617, updated on 5-Jan-2023

Summary

Official Symbol
Ednraprovided by MGI
Official Full Name
endothelin receptor type Aprovided by MGI
Primary source
MGI:MGI:105923
See related
Ensembl:ENSMUSG00000031616 AllianceGenome:MGI:105923
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ETa; ET-AR; AEA001; Gpcr10; Mhdaaea1
Summary
Enables endothelin receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; circulatory system development; and neuron differentiation. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; neural crest cell development; and regulation of glucose transmembrane transport. Located in cell periphery. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and genitourinary system. Used to study mandibulofacial dysostosis with alopecia and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 16.9), limb E14.5 (RPKM 15.1) and 25 other tissues See more
Orthologs
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Genomic context

See Ednra in Genome Data Viewer
Location:
8; 8 C1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (78389658..78451081, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (77663029..77724452, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700092C02 gene Neighboring gene predicted gene, 39200 Neighboring gene RIKEN cDNA 4933431K23 gene Neighboring gene RIKEN cDNA 4933431K23 gene Neighboring gene VISTA enhancer mm761 Neighboring gene uncharacterized LOC108167319 Neighboring gene predicted gene, 39201 Neighboring gene predicted gene, 29845

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (13)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables endothelin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables endothelin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in artery smooth muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial cardiac muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis involved in innervation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in blood vessel morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium ion transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac chamber formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to follicle-stimulating hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to human chorionic gonadotropin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to human chorionic gonadotropin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to luteinizing hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to organic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cranial skeletal system development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic heart tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic skeletal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endothelin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in endothelin receptor signaling pathway involved in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in enteric nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in establishment of endothelial barrier IDA
Inferred from Direct Assay
more info
PubMed 
involved_in face development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in face development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glomerular endothelium development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glomerular filtration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in glomerular filtration ISO
Inferred from Sequence Orthology
more info
 
involved_in glomerulus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within head development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heparin metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in histamine secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in left ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle process involved in oocyte maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesenchymal cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in middle ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrion organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism aging IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in multicellular organism aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural crest cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural crest cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neural crest cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural crest cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in noradrenergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in norepinephrine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in penile erection ISO
Inferred from Sequence Orthology
more info
 
involved_in pharyngeal arch artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in podocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in podocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in podocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kidney development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of odontogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in protein kinase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of heart rate IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization to cell leading edge IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renal albumin absorption IDA
Inferred from Direct Assay
more info
PubMed 
involved_in renal albumin absorption IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in renal albumin absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in renal sodium ion absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within respiratory gaseous exchange by respiratory system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to acetylcholine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to amphetamine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to morphine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in specification of segmental identity, mandibular segment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in specification of segmental identity, maxillary segment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sympathetic neuron axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in thyroid gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vascular associated smooth muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasoconstriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
endothelin-1 receptor
Names
ET-A
G-protein coupled receptor 10
endothelin A receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010332.2NP_034462.1  endothelin-1 receptor precursor

    See identical proteins and their annotated locations for NP_034462.1

    Status: VALIDATED

    Source sequence(s)
    AK043210, AV351599, CN669253
    Consensus CDS
    CCDS22427.1
    UniProtKB/Swiss-Prot
    Q61614, Q91VV2
    Related
    ENSMUSP00000034029.8, ENSMUST00000034029.8
    Conserved Domains (1) summary
    pfam00001
    Location:97367
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    78389658..78451081 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)