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aarsd1 alanyl-tRNA synthetase domain containing 1 [ Danio rerio (zebrafish) ]

Gene ID: 445178, updated on 12-Sep-2024

Summary

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Official Symbol
aarsd1provided by ZNC
Official Full Name
alanyl-tRNA synthetase domain containing 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-91
See related
Ensembl:ENSDARG00000015747 AllianceGenome:ZFIN:ZDB-GENE-040801-91
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
im:7152658; zgc:101066
Summary
Predicted to enable Ser-tRNA(Ala) hydrolase activity. Predicted to be involved in regulation of translational fidelity. Predicted to act upstream of or within tRNA aminoacylation and translation. Predicted to be located in cytoplasm. Is expressed in midbrain; myotome; optic vesicle; pectoral fin; and retina. Orthologous to several human genes including PTGES3L-AARSD1 (PTGES3L-AARSD1 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (6049358..6063311, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (6015774..6029727, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 1 Neighboring gene glucose-6-phosphatase catalytic subunit 1a, tandem duplicate 2 Neighboring gene sphingomyelin synthase 1b Neighboring gene N-acylsphingosine amidohydrolase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification, expression and regulation of amphioxus G6Pase gene with an emphasis on origin of liver. Wang Y, et al. Gen Comp Endocrinol, 2015 Apr 1. PMID 25745818
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Ser-tRNA(Ala) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of translational fidelity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alanyl-tRNA editing protein Aarsd1
Names
alanyl-tRNA synthetase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003572.1 → NP_001003572.1  alanyl-tRNA editing protein Aarsd1

    See identical proteins and their annotated locations for NP_001003572.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077118
    UniProtKB/Swiss-Prot
    Q6DEJ5
    Related
    ENSDARP00000011878.8, ENSDART00000002583.10
    Conserved Domains (2) summary
    COG2872
    Location:8 → 248
    AlaX; Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis]
    cl08469
    Location:42 → 230
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    6049358..6063311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DEJ5.1 GenPept UniProtKB/Swiss-Prot:Q6DEJ5

Gene LinkOut

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