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AARSD1 alanyl-tRNA synthetase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 80755, updated on 21-Dec-2017
Official Symbol
AARSD1provided by HGNC
Official Full Name
alanyl-tRNA synthetase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:28417
See related
Ensembl:ENSG00000266967 MIM:613212; Vega:OTTHUMG00000153515
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 38.9), brain (RPKM 14.2) and 25 other tissues See more
Orthologs
Location:
17q21.31
Exon count:
12
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (42950526..42964498, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41102543..41116515, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene glucose-6-phosphatase catalytic subunit Neighboring gene RNA, Ro-associated Y4 pseudogene 2 Neighboring gene PTGES3L-AARSD1 readthrough Neighboring gene prostaglandin E synthase 3 like Neighboring gene RUN domain containing 1 Neighboring gene ribosomal protein L27

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Protein interactions

Protein Gene Interaction Pubs
Nef nef AARSD1 mRNA is selectively retained in HIV-1 Nef-expressing cellular exosomes, and three miRNAs (miR-16, miR-30c, and miR-30e*) which target AARSD1 mRNA are selectively secreted in exosomes from these cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC2744

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Ser-tRNA(Ala) hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
alanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
alanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
 
aminoacyl-tRNA metabolism involved in translational fidelity IEA
Inferred from Electronic Annotation
more info
 
biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 
Preferred Names
alanyl-tRNA editing protein Aarsd1
Names
alanyl-tRNA synthetase domain-containing protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261434.1NP_001248363.1  alanyl-tRNA editing protein Aarsd1

    See identical proteins and their annotated locations for NP_001248363.1

    Status: VALIDATED

    Source sequence(s)
    AC055866, AL515977, AW296090, BP368900, CA951145
    Consensus CDS
    CCDS58552.1
    UniProtKB/Swiss-Prot
    Q9BTE6
    Related
    ENSP00000400870.1, OTTHUMP00000272277, ENST00000427569.6, OTTHUMT00000467729
    Conserved Domains (2) summary
    COG2872
    Location:8248
    AlaX; Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis]
    cl08469
    Location:40236
    tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

    Range
    42950526..42964498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    41338174..41352160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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