flw flapwing [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: flwprovided by FlyBase
Official Full Name: flapwingprovided by FlyBase
Primary source: FLYBASE:FBgn0000711
Locus tag: Dmel_CG2096
See related: AllianceGenome:FB:FBgn0000711
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO03040301.120; CG15305; CG2096; Dmel\CG2096; DmPp1-9C; FLW; FLW/PP1B; l(1)G0172; PP-1; PP-1c; PP1; PP1 9C; PP1 b9C; PP1 beta9c; Pp1-9C; PP19C; PP1beta; Pp1beta-9C; PP1beta-9C; Pp1beta9C; PP1beta9C; PP1B_DROME; PP1c; PP1cbeta; XE55
Summary: Enables myosin phosphatase activity. Involved in several processes, including oogenesis; regulation of actomyosin contractile ring contraction; and regulation of signal transduction. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic/larval dorsal vessel; embryonic/larval muscle system; and ovariole. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 9B14-9C1; 1-31 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (10385960..10409817)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (10279993..10303850)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

flw is a key regulator of basal myosin oscillations and cell contractions underlying egg chamber elongation.
Title: Myosin light-chain phosphatase regulates basal actomyosin oscillations during morphogenesis.
Flw functions together with myosin phosphatase 1beta to negatively regulate myosin activity during ring canal formation in oogenesis.
Title: Protein phosphatase 1ß limits ring canal constriction during Drosophila germline cyst formation.
Drosophila melanogaster protein phosphatase type 1 beta (flapwing) co-regulates dephosphorylation and altered activity of both Merlin and Moesin.
Title: The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila.
identified a loss-of-function mutation of flapwing, which encodes the catalytic subunit of protein phosphatase 1beta (PP1beta) that disrupts oocyte polarization
Title: Regulation of somatic myosin activity by protein phosphatase 1β controls Drosophila oocyte polarization.
Overexpression of the PP1 alpha isozymes does not rescue semilethal PP1 beta 9C mutants, whereas overexpression of either PP1 alpha 96A or PP1 beta 9C does rescue a lethal PP1 alpha 87B mutant combination.
Title: Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes.
a Jun N-terminal kinase (JNK) mutant suppresses the semilethality of a strong flw allele
Title: The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila.
Data show that Drosophila PP1beta, a specific isoform of serine/threonine protein phosphatase 1 (PP1), regulates nonmuscle myosin and that this is the essential role of PP1beta.
Title: The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin.
Results suggest that protein phosphatase 1beta9C and Trithorax cooperate in Drosophila wing development.
Title: PP1beta9C interacts with Trithorax in Drosophila wing development.
nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1c) interact in vivo in Drosophila
Title: Functional interaction between nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1) in Drosophila: consequences of over-expression of NIPP1 in flies and suppression by co-expression of PP1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germline ring canal formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesoderm development	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of JNK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ovarian nurse cell to oocyte transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of actomyosin contractile ring contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glycogen biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of glycogen catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of morphogenesis of an epithelium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striated muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 1 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: flapwing

Names: CG2096-PA; CG2096-PB; CG2096-PC; CG2096-PD; PP1beta9C; flap wing; flw-PA; flw-PB; flw-PC; flw-PD; protein phosphatase 1; protein phosphatase 1beta at 9C

NP_001259407.1

EC 3.-.-.-

EC 3.1.3.16

NP_001356939.1

EC 3.-.-.-

EC 3.1.3.16

NP_524738.1

EC 3.-.-.-

EC 3.1.3.16

NP_727418.1

EC 3.-.-.-

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

10385960..10409817

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272478.1 → NP_001259407.1 flapwing, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259407.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48462, Q9W2V5

UniProtKB/TrEMBL

H5V895, Q8SWU9

Conserved Domains (1) summary

cd07414
Location:7 → 297

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
NM_167229.2 → NP_727418.1 flapwing, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727418.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T0U6, Q9W2V6

Related

FBpp0071381

Conserved Domains (2) summary

smart00156
Location:160 → 430

PP2Ac; Protein phosphatase 2A homologues, catalytic domain

cd07414
Location:149 → 428

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
NM_001369992.1 → NP_001356939.1 flapwing, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K293, Q8SWU9

Conserved Domains (1) summary

cd07414
Location:7 → 297

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
NM_079999.3 → NP_524738.1 flapwing, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524738.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P48462, Q9W2V5

UniProtKB/TrEMBL

H5V895, Q8SWU9

Related

FBpp0071382

Conserved Domains (1) summary

cd07414
Location:7 → 297

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain