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    flw flapwing [ Drosophila melanogaster ]

    Gene ID: 44289, updated on 10-May-2012
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    Summary

    Official Symbol
    flwprovided by Flybase
    Official Full Name
    flapwingprovided by Flybase
    Primary source
    FLYBASE:FBgn0000711
    Locus tag
    Dmel_CG2096
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.120; CG15305; CG2096; Dmel\CG2096; DmPp1-9C; FLW; FLW/PP1B; l(1)G0172; PP-1; PP1; PP1 9C; PP1 b9C; PP1 beta9c; PP19C; PP1beta; Pp1beta-9C; PP1beta-9C; PP1beta9C; PP1B_DROME; PP1c
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    Genomic context

    Location :
    9B14-9C1; 1-31 cM
    Sequence :
    Chromosome: X; NC_004354.3 (10279966..10302119)
    See flw in Epigenomics, MapViewer

    Chromosome X - NC_004354.3Genomic Context describing neighboring genes Neighboring gene CG17841 gene product from transcript CG17841-RA Neighboring gene CG32681 gene product from transcript CG32681-RA Neighboring gene CG2222 gene product from transcript CG2222-RA Neighboring gene CG32683 gene product from transcript CG32683-RA Neighboring gene CG2885 gene product from transcript CG2885-RA Neighboring gene CG12640 gene product from transcript CG12640-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila. Yang Y, et al. Dev Biol, 2012 Jan 15. PMID 22133918.
    2. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    3. Regulation of somatic myosin activity by protein phosphatase 1β controls Drosophila oocyte polarization. Sun Y, et al. Development, 2011 May. PMID 21490061.
    4. Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. Jiang Y, et al. Oncogene, 2011 Jul 21. PMID 21399659.
    5. Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis. Neubueser D, et al. Mol Biol Cell, 2010 Aug 15. PMID 20573980.

    See all (63) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Drosophila melanogaster protein phosphatase type 1 beta (flapwing) co-regulates dephosphorylation and altered activity of both Merlin and Moesin.
      Title: The PP1 phosphatase flapwing regulates the activity of Merlin and Moesin in Drosophila.
    2. identified a loss-of-function mutation of flapwing, which encodes the catalytic subunit of protein phosphatase 1beta (PP1beta) that disrupts oocyte polarization
      Title: Regulation of somatic myosin activity by protein phosphatase 1β controls Drosophila oocyte polarization.
    3. Overexpression of the PP1 alpha isozymes does not rescue semilethal PP1 beta 9C mutants, whereas overexpression of either PP1 alpha 96A or PP1 beta 9C does rescue a lethal PP1 alpha 87B mutant combination.
      Title: Essential, overlapping and redundant roles of the Drosophila protein phosphatase 1 alpha and 1 beta genes.
    4. a Jun N-terminal kinase (JNK) mutant suppresses the semilethality of a strong flw allele
      Title: The nonmuscle myosin phosphatase PP1beta (flapwing) negatively regulates Jun N-terminal kinase in wing imaginal discs of Drosophila.
    5. Data show that Drosophila PP1beta, a specific isoform of serine/threonine protein phosphatase 1 (PP1), regulates nonmuscle myosin and that this is the essential role of PP1beta.
      Title: The essential role of PP1beta in Drosophila is to regulate nonmuscle myosin.
    6. Results suggest that protein phosphatase 1beta9C and Trithorax cooperate in Drosophila wing development.
      Title: PP1beta9C interacts with Trithorax in Drosophila wing development.
    7. nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1c) interact in vivo in Drosophila
      Title: Functional interaction between nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1) in Drosophila: consequences of over-expression of NIPP1 in flies and suppression by co-expression of PP1.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:68952 BioGRID:58653 Bap60    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:67380 CG10889    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:61033 CG12620    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:62132 CG13157    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:64968 CG13458    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:61287 CG2608    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:57754 CG2865    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:61390 CG3262    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:60729 CG5792    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:61992 Cpr47Eg    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:62954 Cpr56F    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:57914 HLH4C    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:64543 I-2    BioGRID  PubMed Affinity Capture-MS; Phenotypic Suppression 
    BioGRID:68952 BioGRID:58363 Idgf4    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:67007 Mhcl    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:69245 NiPp1    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:68952 BioGRID:68753 Plap    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:72126 Pp1-87B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:68952 BioGRID:68391 RpS8    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:60212 TwdlE    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:64396 Zasp66    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:65901 elm    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:62866 ena    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:59169 phm    BioGRID  PubMed Two-hybrid 
    BioGRID:68952 BioGRID:67127 sds22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:68952 BioGRID:57568 svr    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the flw gene: The flw gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, A.thaliana, and rice.

    Pathways from BioSystems

    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    myosin phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    cell adhesion NAS
    Non-traceable Author Statement
    more info
    		  
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    female germline ring canal formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    instar larval development NAS
    Non-traceable Author Statement
    more info
    		  
    mesoderm development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    muscle attachment NAS
    Non-traceable Author Statement
    more info
    		  
    negative regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    ovarian nurse cell to oocyte transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein dephosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    striated muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    protein phosphatase type 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG2096 gene product from transcript CG2096-RB
    Names
    CG2096-PA
    CG2096-PB
    PP1beta9C
    flap wing
    flapwing
    flw-PA
    flw-PB
    protein phosphatase 1
    protein phosphatase 1beta at 9C
    NP_524738.1
    NP_727418.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.3

      Range
      10279966..10302119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079999.2 → NP_524738.1  flapwing, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V895
      UniProtKB/Swiss-Prot
      P48462
      Related
      FBpp0071382, FBtr0071447
      Conserved Domains (2) summary
      cd07414
      Location:7 – 299
      Blast Score: 1627
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
      PTZ00480
      Location:5 – 300
      Blast Score: 1322
      PTZ00480; serine/threonine-protein phosphatase; Provisional

    2. NM_167229.1 → NP_727418.1  flapwing, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0U6
      Related
      FBpp0071381, FBtr0071446
      Conserved Domains (2) summary
      cd07414
      Location:149 – 430
      Blast Score: 1593
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
      smart00156
      Location:160 – 430
      Blast Score: 1043
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA X56439.1 CAA39821.1
    genomic AE014298.4 AAF46583.2
    mRNA BT133196.1 AFA28437.1
    mRNA AY069047.1 AAL39192.1
    genomic AE014298.4 AAF46582.2
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48462.1 GenPept
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    Additional Links

    Gene LinkOut

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