FMR1 Fragile X messenger ribonucleoprotein 1 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: FMR1provided by CGNC
Official Full Name: Fragile X messenger ribonucleoprotein 1provided by CGNC
Primary source: CGNC:51729
See related: Ensembl:ENSGALG00010016449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (18571708..18602554, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (18610625..18641485, complement)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation.
Title: Dynamics of the fragile X mental retardation protein correlates with cellular and synaptic properties in primary auditory neurons following afferent deprivation.
Temporal-specific roles of fragile X mental retardation protein in the development of the hindbrain auditory circuit.
Title: Temporal-specific roles of fragile X mental retardation protein in the development of the hindbrain auditory circuit.
these data demonstrate that proper levels of postsynaptic FMRP are required for timely maturation of somatodendritic morphology, a delay of which may affect synaptogenesis and thus contribute to long-lasting deficits of excitatory synapses
Title: Postsynaptic FMRP Regulates Synaptogenesis In Vivo in the Developing Cochlear Nucleus.
Study provides a database of highly expressed proteins in the avian nucleus laminaris brainstem nucleus and in particular a list of potential FMRP targets, with the goal of facilitating molecular characterization of FMRP signaling in future studies.
Title: Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables translation regulator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in anterograde axonal transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of translation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of dendrite morphogenesis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of dendritic spine development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of filopodium assembly	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of mRNA stability	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of modification of synaptic structure	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of translation at postsynapse, modulating synaptic transmission	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendritic filopodium	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendritic spine	IEA Inferred from Electronic Annotation more info	PubMed
located_in dendritic spine neck	IEA Inferred from Electronic Annotation more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info	PubMed
located_in neuronal ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info	PubMed
located_in presynapse	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: fragile X messenger ribonucleoprotein 1; synaptic functional regulator FMR1

Names: FMRP translational regulator 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001389656.2 → NP_001376585.1 fragile X messenger ribonucleoprotein 1

Status: VALIDATED

Source sequence(s)

JAENSK010000071

UniProtKB/TrEMBL

A0A8V0YVW7, F1NF19

Related

ENSGALP00010022890.1, ENSGALT00010039631.1

Conserved Domains (7) summary

pfam12235
Location:354 → 458

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

pfam16098
Location:483 → 548

FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2

cd20471
Location:1 → 55

Tudor_Agenet_FMR1_rpt1; first Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins

cd20474
Location:58 → 120

Tudor_Agenet_FMR1_rpt2; second Tudor-like Agenet domain found in synaptic functional regulator FMR1 and similar proteins

cd22506
Location:123 → 199

KH_I_FMR1_rpt1; first type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins

cd22509
Location:218 → 280

KH_I_FMR1_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins

cd22512
Location:281 → 358

KH_I_FMR1_rpt3; third type I K homology (KH) RNA-binding domain found in fragile X mental retardation protein 1 (FMR1) and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

18571708..18602554 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025149834.3 → XP_025005602.1 synaptic functional regulator FMR1 isoform X2

UniProtKB/TrEMBL

A0A8V0YVW7, A0A8V0Z2R0

Related

ENSGALP00010022892.1, ENSGALT00010039633.1

Conserved Domains (6) summary

smart00322
Location:221 → 280

KH; K homology RNA-binding domain

cd00105
Location:286 → 347

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

pfam12235
Location:354 → 459

FXMRP1_C_core; Fragile X-related 1 protein core C terminal

pfam16098
Location:483 → 565

FXMR_C2; Fragile X-related mental retardation protein C-terminal region 2

pfam17904
Location:123 → 207

KH_9; FMRP KH0 domain

pfam18336
Location:4 → 52

Tudor_FRX1; Fragile X mental retardation Tudor domain
XM_046940046.1 → XP_046796002.1 synaptic functional regulator FMR1 isoform X3

UniProtKB/TrEMBL

A0A8V0YVW7
XM_046940045.1 → XP_046796001.1 synaptic functional regulator FMR1 isoform X1

UniProtKB/TrEMBL

A0A8V0YVW7
XM_015285261.4 → XP_015140747.1 synaptic functional regulator FMR1 isoform X5

UniProtKB/TrEMBL

A0A8V0YPG9, A0A8V0YXV1

Related

ENSGALP00010022886.1, ENSGALT00010039627.1

Conserved Domains (4) summary

smart00322
Location:221 → 280

KH; K homology RNA-binding domain

pfam00013
Location:283 → 351

KH_1; KH domain

pfam05641
Location:63 → 120

Agenet; Agenet domain

pfam12235
Location:354 → 505

FXMRP1_C_core; Fragile X-related 1 protein core C terminal
XM_046940047.1 → XP_046796003.1 synaptic functional regulator FMR1 isoform X4

UniProtKB/TrEMBL

A0A8V0YXV1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

18610625..18641485 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046915862.1 → XP_046771818.1 synaptic functional regulator FMR1 isoform X2

UniProtKB/TrEMBL

A0A8V0YVW7, A0A8V0Z2R0
XM_046915863.1 → XP_046771819.1 synaptic functional regulator FMR1 isoform X3

UniProtKB/TrEMBL

A0A8V0YVW7
XM_046915861.1 → XP_046771817.1 synaptic functional regulator FMR1 isoform X1

UniProtKB/TrEMBL

A0A8V0YVW7
XM_046915865.1 → XP_046771821.1 synaptic functional regulator FMR1 isoform X5

UniProtKB/TrEMBL

A0A8V0YPG9, A0A8V0YXV1
XM_046915864.1 → XP_046771820.1 synaptic functional regulator FMR1 isoform X4

UniProtKB/TrEMBL

A0A8V0YXV1