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CYP21A2 cytochrome P450c21 [ Canis lupus familiaris (dog) ]

Gene ID: 415124, updated on 5-Mar-2024

Summary

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Gene symbol
CYP21A2
Gene description
cytochrome P450c21
See related
Ensembl:ENSCAFG00845014419
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
CYP21; CYP21A
Orthologs
human mouse all
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Genomic context

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See CYP21A2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 12 NC_051816.1 (1592467..1595553)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 12 NC_006594.4 (1585423..1588446)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 12 NC_049233.1 (1584769..1587792)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 12 NC_049272.1 (1449980..1453003)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 12 NC_049753.1 (1518170..1521193)

Chromosome 12 - NC_051816.1Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 19 Neighboring gene complement C4-A Neighboring gene tenascin XB Neighboring gene uncharacterized LOC119874141 Neighboring gene activating transcription factor 6 beta Neighboring gene uncharacterized LOC119874140 Neighboring gene FKBP prolyl isomerase like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of canine 21-hydroxylase gene and its polymorphic analysis as a candidate gene for congenital adrenal hyperplasia-like syndrome in Pomeranians. Takada K, et al. Res Vet Sci, 2002 Oct. PMID 12204635

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 17-alpha-hydroxyprogesterone aldolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid 17-alpha-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in progesterone metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
steroid 21-hydroxylase
Names
21-OHase
21-hydroxylase
cytochrome P-450c21
cytochrome P450 21
cytochrome P450 XXI
cytochrome P450, family 21, subfamily A
cytochrome P450-C21
NP_001003335.1
XP_038538621.1
XP_038538622.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003335.1 → NP_001003335.1  steroid 21-hydroxylase

    See identical proteins and their annotated locations for NP_001003335.1

    Status: PROVISIONAL

    Source sequence(s)
    AB039881
    UniProtKB/TrEMBL
    A0A8C0SWL8, A0A8I3NW67, Q9N2C7
    Related
    ENSCAFP00845020357.1, ENSCAFT00845025836.1
    Conserved Domains (1) summary
    pfam00067
    Location:28 → 449
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051816.1 Reference ROS_Cfam_1.0

    Range
    1592467..1595553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038682693.1 → XP_038538621.1  steroid 21-hydroxylase isoform X1

    Conserved Domains (1) summary
    cl41757
    Location:55 → 369
    cytochrome_P450; cytochrome P450 (CYP) superfamily

  2. XM_038682694.1 → XP_038538622.1  steroid 21-hydroxylase isoform X2

    Conserved Domains (1) summary
    cl41757
    Location:1 → 345
    cytochrome_P450; cytochrome P450 (CYP) superfamily

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049272.1 Alternate UMICH_Zoey_3.1

    Range
    1449980..1453003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049753.1 Alternate UNSW_CanFamBas_1.0

    Range
    1518170..1521193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049233.1 Alternate UU_Cfam_GSD_1.0

    Range
    1584769..1587792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006594.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    1585423..1588446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WNW0.1 GenPept UniProtKB/Swiss-Prot:Q8WNW0

Gene LinkOut

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Molecular Biology Databases
Research Materials