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Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 13079, updated on 29-May-2018

Summary

Official Symbol
Cyp21a1provided by MGI
Official Full Name
cytochrome P450, family 21, subfamily a, polypeptide 1provided by MGI
Primary source
MGI:MGI:88591
See related
Ensembl:ENSMUSG00000024365 Vega:OTTMUSG00000037259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
21OH; 21-OH; 21OHA; 21OHB; Cyp21; Cyp21B; Oh21-1; Oh21-2; CYP21OH-A; Cyp21-ps1; Cyp21a2ps; Cyp21a2-ps
Expression
Restricted expression toward adrenal adult (RPKM 8124.5) See more
Orthologs

Genomic context

See Cyp21a1 in Genome Data Viewer
Location:
17 B1; 17 18.36 cM
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (34801348..34804426, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (34938293..34941371, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 19, pseudogene 1 Neighboring gene superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1 Neighboring gene tenascin XA (pseudogene) Neighboring gene complement component 4A (Rodgers blood group) Neighboring gene serine/threonine kinase 19

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC156449

Gene Ontology Provided by MGI

Function Evidence Code Pubs
heme binding ISO
Inferred from Sequence Orthology
more info
 
iron ion binding IEA
Inferred from Electronic Annotation
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
 
steroid 21-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
steroid binding IEA
Inferred from Electronic Annotation
more info
 
steroid hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
C21-steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
mineralocorticoid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
progesterone metabolic process ISO
Inferred from Sequence Orthology
more info
 
steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
steroid metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
steroid 21-hydroxylase
Names
21-OHase
21-hydroxylase
cytochrome P-450
cytochrome P-450c21
cytochrome P450 21
cytochrome P450 XXI
cytochrome P450 hydroxylase A
cytochrome P450, 21, pseudogene
cytochrome P450, 21, steroid 21 hydroxylase
cytochrome P450, family 21, subfamily a, polypeptide 2, pseudogene
cytochrome P450-C21
NP_034125.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009995.2NP_034125.2  steroid 21-hydroxylase precursor

    See identical proteins and their annotated locations for NP_034125.2

    Status: VALIDATED

    Source sequence(s)
    AI323066, AK146565, BC127167, BQ033552
    Consensus CDS
    CCDS28658.1
    UniProtKB/Swiss-Prot
    P03940
    UniProtKB/TrEMBL
    A0A0R4J048, Q3UJ92
    Related
    ENSMUSP00000025223.7, OTTMUSP00000053643, ENSMUST00000025223.8, OTTMUST00000096082
    Conserved Domains (1) summary
    pfam00067
    Location:29471
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    34801348..34804426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 129X1/SvJ

Genomic

  1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

    Range
    1050122..1053200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 NOD/MrkTac

Genomic

  1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

    Range
    1119472..1122559 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 NOD/ShiLtJ

Genomic

  1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

    Range
    1119719..1122806 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_001363.1: Suppressed sequence

    Description
    NG_001363.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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