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SELP selectin P [ Canis lupus familiaris (dog) ]

Gene ID: 403994, updated on 5-Mar-2024

Summary

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Official Symbol
SELPprovided by VGNC
Official Full Name
selectin Pprovided by VGNC
Primary source
VGNC:VGNC:45985
See related
Ensembl:ENSCAFG00845002229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
GMP140
Orthologs
human mouse all
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Genomic context

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See SELP in Genome Data Viewer
Location:
chromosome: 7
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 7 NC_051811.1 (28758392..28799283)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 7 NC_006589.4 (28490155..28527988)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 7 NC_049228.1 (28881019..28918852)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 7 NC_049267.1 (28608516..28646330)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 7 NC_049748.1 (28644251..28682064)

Chromosome 7 - NC_051811.1Genomic Context describing neighboring genes Neighboring gene selectin L Neighboring gene uncharacterized LOC119872675 Neighboring gene coagulation factor V Neighboring gene uncharacterized LOC111096889

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Flow cytometric evaluation of disseminated intravascular coagulation in a canine endotoxemia model. Yu D, et al. Can J Vet Res, 2015 Jan. PMID 25673909, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P-selectin expression on platelets increased significantly over time in dogs with endotoxemia and disseminated intravascular coagulation.
    Title: Flow cytometric evaluation of disseminated intravascular coagulation in a canine endotoxemia model.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables oligosaccharide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sialic acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in leukocyte tethering or rolling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to cytokine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
P-selectin
Names
cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287149.1 → NP_001274078.1  P-selectin

    Status: VALIDATED

    Source sequence(s)
    DN878037, M88170
    UniProtKB/TrEMBL
    A0A8C0Q3D2, A0A8I3MKI2, Q28290
    Related
    ENSCAFP00845003168.1, ENSCAFT00845003967.1
    Conserved Domains (4) summary
    cd00033
    Location:262 → 320
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    cd00054
    Location:168 → 195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl02432
    Location:42 → 160
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    cl27761
    Location:443 → 700
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051811.1 Reference ROS_Cfam_1.0

    Range
    28758392..28799283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038670497.1 → XP_038526425.1  P-selectin isoform X1

    UniProtKB/TrEMBL
    A0A8C0PRQ0, A0A8C0PTS8, A0A8I3RQK1
    Conserved Domains (4) summary
    cd00033
    Location:448 → 506
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:219 → 443
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168 → 195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl02432
    Location:42 → 160
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  2. XM_038670498.1 → XP_038526426.1  P-selectin isoform X2

    UniProtKB/TrEMBL
    A0A8C0RSQ3, A0A8C0RSQ7, A0A8I3RQL3
    Related
    ENSCAFP00845003211.1, ENSCAFT00845004015.1
    Conserved Domains (4) summary
    cd00033
    Location:448 → 506
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:219 → 443
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168 → 195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl02432
    Location:42 → 160
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  3. XM_038670496.1 → XP_038526424.1  P-selectin isoform X1

    UniProtKB/TrEMBL
    A0A8C0PRQ0, A0A8C0PTS8, A0A8I3RQK1
    Related
    ENSCAFP00845003139.1, ENSCAFT00845003938.1
    Conserved Domains (4) summary
    cd00033
    Location:448 → 506
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02927
    Location:219 → 443
    PHA02927; secreted complement-binding protein; Provisional
    cd00054
    Location:168 → 195
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl02432
    Location:42 → 160
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049267.1 Alternate UMICH_Zoey_3.1

    Range
    28608516..28646330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049748.1 Alternate UNSW_CanFamBas_1.0

    Range
    28644251..28682064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049228.1 Alternate UU_Cfam_GSD_1.0

    Range
    28881019..28918852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006589.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    28490155..28527988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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