CHGA chromogranin A [Sus scrofa (pig)] - Gene

Summary

Official Symbol: CHGAprovided by VGNC
Official Full Name: chromogranin Aprovided by VGNC
Primary source: VGNC:VGNC:103919
See related: Ensembl:ENSSSCG00000002456
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Restricted expression toward ovary (RPKM 168.6) See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	7	NC_010449.5 (114345542..114357799)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	7	NC_010449.4 (120954018..120966278)

Chromosome 7 - NC_010449.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High pancreastatin levels are significantly associated with neuroendocrine tumors.
Title: Pancreastatin predicts survival in neuroendocrine tumors.
No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring.
Title: Saliva chromogranin A in growing pigs: a study of circadian patterns during daytime and stability under different storage conditions.
expression and localization of chromogranin A (CgA), chromogranin B (CgB), synaptophysin, and insulin were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells
Title: Cellular expression and specific intragranular localization of chromogranin A, chromogranin B, and synaptophysin during ontogeny of pancreatic islet cells: an ultrastructural study.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of catecholamine secretion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of insulin secretion	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in chromaffin granule	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: chromogranin-A

Names: cgA; chromogranin A (parathyroid secretory protein 1); pancreastatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164005.2 → NP_001157477.2 chromogranin-A precursor

Status: PROVISIONAL

Source sequence(s)

AK347690, AU296097, EW465138, FS657527, FS658372, M20926

UniProtKB/TrEMBL

A0A480Z7I2, A0A480ZDS7

Related

ENSSSCP00000002657.3, ENSSSCT00000002726.5

Conserved Domains (2) summary

pfam01271
Location:25 → 448

Granin; Granin (chromogranin or secretogranin)

cl01868
Location:75 → 147

YukC; WXG100 protein secretion system (Wss), protein YukC