SELE selectin E [Sus scrofa (pig)] - Gene

Summary

Gene symbol: SELE
Gene description: selectin E
See related: Ensembl:ENSSSCG00000006286
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Broad expression in kidney (RPKM 1.4), lung (RPKM 1.1) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	4	NC_010446.5 (81289061..81299657)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	4	NC_010446.4 (88914255..88924371)

Chromosome 4 - NC_010446.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 by inhibiting the phosphorylation of Mitogen-Activated Protein Kinases and the activation of NF-kappaB in lipopolysaccharides treated porcine iliac artery endothelial cells.
Title: Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling.
Increased E-selectin mRNA at end of 20 hours of cold ischemia time might indicate a preactivated state of endothelial cells potentially triggered by bacterial translocation or products.
Title: Expression of E-selectin and its transcripts during intestinal ischemia-reperfusion injury in pigs.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables oligosaccharide binding	IEA Inferred from Electronic Annotation more info	PubMed
enables sialic acid binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed
involved_in leukocyte tethering or rolling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: E-selectin

Names: CD62 antigen-like family member E; ELAM-1; LECAM2; endothelial leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 2; selectin E (endothelial adhesion molecule 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214268.2 → NP_999433.2 E-selectin precursor

Status: PROVISIONAL

Source sequence(s)

L39076, U08350

UniProtKB/TrEMBL

A0A4X1UX95, A0A8D1GWP9, F1RSC6

Related

ENSSSCP00000006699.1, ENSSSCT00000006887.4

Conserved Domains (4) summary

cd00033
Location:366 → 421

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:23 → 141

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

cd00054
Location:149 → 176

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cl27761
Location:200 → 361

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010446.5 Reference Sscrofa11.1 Primary Assembly

Range

81289061..81299657

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_013996784.2 → XP_013852238.1 E-selectin isoform X1

UniProtKB/TrEMBL

A0A8D1GWP9

Conserved Domains (3) summary

cd00033
Location:181 → 236

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03592
Location:23 → 141

CLECT_selectins_like; C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)

cd00054
Location:149 → 176

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...