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DNASE2 deoxyribonuclease 2, lysosomal [ Sus scrofa (pig) ]

Gene ID: 397398, updated on 5-Mar-2024

Summary

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Official Symbol
DNASE2provided by VGNC
Official Full Name
deoxyribonuclease 2, lysosomalprovided by VGNC
Primary source
VGNC:VGNC:87377
See related
Ensembl:ENSSSCG00000013731
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
DNL2; DNASE2A
Expression
Broad expression in lung (RPKM 65.2), spleen (RPKM 44.3) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See DNASE2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
6
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 2 NC_010444.4 (66150071..66152857)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 2 NC_010444.3 (66447511..66450524, complement)

Chromosome 2 - NC_010444.4Genomic Context describing neighboring genes Neighboring gene synaptonemal complex central element protein 2 Neighboring gene glutaryl-CoA dehydrogenase Neighboring gene KLF transcription factor 1 Neighboring gene microtubule associated serine/threonine kinase 1 Neighboring gene retbindin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Leukocyte elastase inhibitor: a new regulator of PARP-1. Leprêtre C, et al. Ann N Y Acad Sci, 2009 Aug. PMID 19723034
  2. Proteolytic processing of porcine deoxyribonuclease II occurs in lysosomes but is not required for enzyme activation. Huang RT, et al. FEBS J, 2009 Apr. PMID 19292869
  3. Identification of three crucial histidine residues (His115, His132 and His297) in porcine deoxyribonuclease II. Cheng YC, et al. Biochem J, 2006 Sep 1. PMID 16734590, Free PMC Article
  4. Cloning of cDNAs encoding porcine and human DNase II. Shiokawa D, et al. Biochem Biophys Res Commun, 1998 Jun 29. PMID 9647784
  5. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data showed an association between PARP-1 and LEI/L-DNase II.
    Title: Leukocyte elastase inhibitor: a new regulator of PARP-1.
  2. Proteolytic processing of porcine deoxyribonuclease II occurs in lysosomes but is not required for enzyme activation
    Title: Proteolytic processing of porcine deoxyribonuclease II occurs in lysosomes but is not required for enzyme activation.
  3. H115L and H297L mutants were found to undergo correct protein folding, but were inactive
    Title: Identification of three crucial histidine residues (His115, His132 and His297) in porcine deoxyribonuclease II.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables deoxyribonuclease II activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic DNA fragmentation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
deoxyribonuclease-2-alpha
Names
DNase II alpha
acid DNase
deoxyribonuclease II alpha
lysosomal DNase II
NP_999361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214196.1 → NP_999361.1  deoxyribonuclease-2-alpha precursor

    See identical proteins and their annotated locations for NP_999361.1

    Status: PROVISIONAL

    Source sequence(s)
    AF060221
    UniProtKB/Swiss-Prot
    O62855
    UniProtKB/TrEMBL
    A0A4X1TG60, A0A8D1N3K7, F1SDY3
    Related
    ENSSSCP00000014601.3, ENSSSCT00000015005.4
    Conserved Domains (2) summary
    pfam03265
    Location:21 → 347
    DNase_II; Deoxyribonuclease II
    cl15239
    Location:18 → 178
    PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010444.4 Reference Sscrofa11.1 Primary Assembly

    Range
    66150071..66152857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O62855.1 GenPept UniProtKB/Swiss-Prot:O62855

Gene LinkOut

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